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File Ref.No.7054/GA - IV - J1/2013/CU  UNIVERSITY OF CALICUT
File Ref.No.7054/GA - IV - J1/2013/CU UNIVERSITY OF CALICUT

... Enzyme catalysis and Mechanism of enzyme action-: Idea of enzyme specificity; Concept of active site and the ‘lock and key’ model of Emil Fischer; Koshland’s induced fit theory of enzyme catalysis. Standard free energy change in a reaction. Transition state, energy of activation of non-enzymatic and ...
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... transportation into cells by SLC2A4 tends to be more reliant on insulin and insulin-like growth factors levels than on glucose concentration (Charron et al. 1989). In addition to having a poor capacity to take up glucose, the bovine oocyte has low phosphofructokinase activity (PFK, one of the rate-l ...
Objectives 19 - u.arizona.edu
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... 1. HEME SYNTHESIS - heme is an iron containing prosthetic group found in hemoglobin, myoglobin, and cytochromes - heme binds O2, participates in electron transfer, or oxidizes exogenous molecule - reaction for synthesis occur both in cytoplasm and mitochondrial matrix; final step of pathway  incorp ...
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... Under normal aerobic conditions glucose is converted to pyruvate, which is in turn converted to acetyl-CoA. Acetyl-CoA then combines with oxaloacetate to form citrate, and so enters the Krebs cycle. The Krebs cycle of biochemical reactions then produces water, CO2 and most importantly, ATP, the prim ...
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... alanine and glutamine, and modulators of protein synthesis, is governed by their availability. Research suggests that first and foremost the BCAA are used for the synthesis of protein structures (Layman, 2003). Research on leucine shows that once the minimum requirement of leucine for protein synthe ...
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Effects of Oxygen Supply and Mixed Sugar Concentration on D

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Ketosis



Ketosis /kɨˈtoʊsɨs/ is a metabolic state where most of the body's energy supply comes from ketone bodies in the blood, in contrast to a state of glycolysis where blood glucose provides most of the energy. It is characterised by serum concentrations of ketone bodies over 0.5 millimolar, with low and stable levels of insulin and blood glucose. It is almost always generalized with hyperketonemia, that is, an elevated level of ketone bodies in the blood throughout the body. Ketone bodies are formed by ketogenesis when liver glycogen stores are depleted (or from metabolising medium-chain triglycerides). The main ketone bodies used for energy are acetoacetate and β-hydroxybutyrate, and the levels of ketone bodies are regulated mainly by insulin and glucagon. Most cells in the body can use both glucose and ketone bodies for fuel, and during ketosis, free fatty acids and glucose synthesis (gluconeogenesis) fuel the remainder.Longer-term ketosis may result from fasting or staying on a low-carbohydrate diet, and deliberately induced ketosis serves as a medical intervention for intractable epilepsy. In glycolysis, higher levels of insulin promote storage of body fat and block release of fat from adipose tissues, while in ketosis, fat reserves are readily released and consumed. For this reason, ketosis is sometimes referred to as the body's ""fat burning"" mode.
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