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Ass3 - The University of Sydney
Ass3 - The University of Sydney

... synthesis of fatty acids from glucose (lipogenesis) can be written (for the 16carbon fatty acid, palmitate) as: 9 glucose + 8 O2  2 palmitate + 22CO2 + 22 H2O Hint : At this stage you will find it very useful to draw out the scheme of lipogenesis from glucose (eg as in the final slide for Lecture 1 ...
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very new glucogen me..

... It clear the blood from waste product e.g. lactate and glycerol. Location : cytosol and mitochondria of liver and kidney. Organs : liver 90% , kidney 10% Steps: reversal of glycolsis except the Three irreversible kinase which is replaced by the following enzymes : Glukokinase ≠glucose-6-phosphatease ...
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... Fats are converted into acetyl CoA, which is then processed by the citric acid cycle. Oxaloacetate, a citric acid cycle intermediate, is a precursor to glucose. However, acetyl CoA derived from fats cannot lead to the net synthesis of oxaloacetate or glucose because although two carbons enter the c ...
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... – In type 2 diabetes, the body develops impaired insulin production and increased insulin resistance, which leads to increased fat deposition and elevated fatty acid levels. – Cardiovascular disease affects the heart and can lead to hypertension, heart attack, and ...
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Ketosis



Ketosis /kɨˈtoʊsɨs/ is a metabolic state where most of the body's energy supply comes from ketone bodies in the blood, in contrast to a state of glycolysis where blood glucose provides most of the energy. It is characterised by serum concentrations of ketone bodies over 0.5 millimolar, with low and stable levels of insulin and blood glucose. It is almost always generalized with hyperketonemia, that is, an elevated level of ketone bodies in the blood throughout the body. Ketone bodies are formed by ketogenesis when liver glycogen stores are depleted (or from metabolising medium-chain triglycerides). The main ketone bodies used for energy are acetoacetate and β-hydroxybutyrate, and the levels of ketone bodies are regulated mainly by insulin and glucagon. Most cells in the body can use both glucose and ketone bodies for fuel, and during ketosis, free fatty acids and glucose synthesis (gluconeogenesis) fuel the remainder.Longer-term ketosis may result from fasting or staying on a low-carbohydrate diet, and deliberately induced ketosis serves as a medical intervention for intractable epilepsy. In glycolysis, higher levels of insulin promote storage of body fat and block release of fat from adipose tissues, while in ketosis, fat reserves are readily released and consumed. For this reason, ketosis is sometimes referred to as the body's ""fat burning"" mode.
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