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Short-term sensitization of the gill-withdrawal reflex in Aplysia. A. Sensitization of the gill-withdrawal reflex is produced by applying a noxious stimulus to another part of the body, such as the tail. A shock to the tail activates tail sensory neurons that excite facilitating (modulatory) interneurons, which form synapses on the cell body and terminals of the mechanoreceptor sensory neurons that innervate the siphon. Through these axo-axonic synapses the modulatory interneurons enhance transmitter release from the siphon sensory neurons onto their postsynaptic gill motor neurons (presynaptic facilitation), thus enhancing gill withdrawal. Presynaptic facilitation results, in part, from a prolongation of the sensory neuron action potential (bottom traces). (Adapted, with permission, from Pinsker et al. 1970; Klein and Kandel 1980.) Source: Cellular Mechanisms of Implicit Memory Storage and the Biological Basis of Individuality, Principles of Neural Science, Fifth Editon B. Presynaptic facilitation in the sensory neuron is thought to occur by means of two biochemical pathways. The diagram shows details of the synaptic Citation: Kandel ER, Schwartz JH, Jessell TM, Siegelbaum SA, Hudspeth AJ, Mack S. Principles of Neural Science, Fifth Editon; 2012 Available complex in the dashed box in part A. at: http://mhmedical.com/ Accessed: May 06, 2017 Pathway 1: Copyright A facilitating interneuron releases serotonin (5-HT), which binds to metabotropic receptors in the sensory neuron terminal. This action © 2017 McGraw-Hill Education. All rights reserved engages a G protein (Gs), which in turn increases the activity of adenylyl cyclase. The adenylyl cyclase converts ATP to cAMP, which binds to the +