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Download A synaptic memory trace for cortical receptive field plasticity
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Transcript
A synaptic memory trace for cortical receptive field plasticity Robert Froemke Department of Otolaryngology, UCSF, USA 24.7.08 Neural networks of the cerebral cortex continually change throughout life, allowing us to learn from our sensations of the world. While the developing cortex is readily altered by sensory experience, older brains are less plastic. Adult cortical plasticity seems to require more widespread coordination across diverse brain regions, including the activation of subcortical neuromodulator systems, reflecting the importance of behavioural significance and context for learning. Here I will present the results of recent experiments on the synaptic basis of receptive field plasticity in the adult primary auditory cortex. I will describe the changes both to spike output and to synaptic input after sensory stimuli were paired with electrical stimulation of the nucleus basalis- a key center for attention, arousal, and learning. I will then discuss the network elements and temporal dynamics of excitatory and inhibitory synaptic plasticity in vivo.
