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1 HONORS BIOLOGY HOMEWORK CHAPTER 11 MENDELIAN GENETICS 1. A researcher performs a cross between a female pure, white, albino rabbit and a coal-black lop-eared male. This combination produced a random distribution of male/female rabbits all having a gray coat. The experimenters then crossed members of the F1 generation and found the following distribution of coat color: 138 pure white rabbits 161 coal-black rabbits 312 gray coat rabbits Indicate the genotype of the coat color of the White albino rabbit Coal-black rabbit Gray coat rabbit Explain the pattern of distribution seen as a result of the above referenced crosses. 2. From the mating of two red-eyed, wild type fruit flies, what would be the expected probability that a. All of the first three offspring will be female? b. All of the first three offspring will be male? c. All of the siblings will be of the same sex? d. Disregarding the birth order of the three siblings, two will be female and one will be a male? e. Disregarding the birth order, two will be male and one female? 3. Two normal individuals with a family history of cystic fibrosis plan to have children. The gene for cystic fibrosis is a recessive autosomal allele. The father is normal but his mother was diagnosed with the disease. The mother is likewise normal but her father was affected with the disease. a. What are ALL of the possible outcomes from this union? b. What is the probability if there are four children, that all will be unaffected? c. What is the probability if there are four children that all four are affected? 2 4. A plant, heterozygous for three independently assorting genes, AaBbCc is self-fertilized. Among the offspring, predict the frequency of a. AABBCC individuals b. aabbcc individuals c. Individuals that are either AABBCC or aabbcc d. AaBbCc individual 5. In pigeons, a dominant allele C carries a checkered pattern in the feathers; its recessive allele c produces a plain pattern. Feather coloration is controlled by an independently assorting gene, the dominant allele B produces red feathers and the recessive gene b produces brown feathers. Birds from a true-breeding checkered, red variety are crossed to birds from a true-breeding plain, brown variety. a. Predict the phenotype of the progeny b. If these pigeons are “selfed”, what phenotypes will appear in the F2 generation and in what proportion? 6. In cultivated flowers called “stocks”, pigment is controlled by two independently assorting alleles. When the dominant allele A is present at one locus, C_ at the other locus leads to red pigmentation; cc leads to cream pigmentation. The double recessive, aa, at the first locus produces a white flower regardless of the alleles at the second locus. a. If a homozygous red stock is crossed with a white variety, what phenotypic and genotypic ratios are expected in the F1 and F2 generation? b. If a cross between a red stock and a white stock produces progeny of all three phenotypes, what are the genotypes of the parents? 7. Niemann-Pick Disease, Gaucher’s Disease and Tay-Sachs disease are all “lipid-storage diseases, more properly, sphingolipidoses. Point out the similarities among these conditions, both genotypically and phenotypically and indicate what “non-Mendelian” condition they manifest. If a normal mother has a defect for Gaucher’s disease present on an X-chromosome, what will be the probability of a son being affected if the father were also unaffected? If the affected son were to have children with an unaffected female, what would be the likelihood of his sons being affected? 3 8. Show the F1 genotype from the following parental cross and then list the gametes that would result from a “self-cross” of a male and female from that F1 result. AABBCCDD X aabbccdd 9. Define the following terms (maximum two sentences): a. Cosanguinous reproduction b. Pleiotropy c. Epistasis d. Codominance e. Incomplete dominance f. Hemizygous g. Reciprocal cross h. Test cross i. Polygenic traits j. Multifactorial Traits 10. A chromosomally normal woman and a chromosomally normal man have a son whose sex-chromosome constitution is XYY. In which parent, and in which meiotic division did the nondisjunction take place?