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Transcript
Drug Review DRUG REVIEW Any substance that when taken into the living organism may modify one or more of its function is defined as Drug. W.H.O. has given a more comprehensive definition as “Drug is any substance or product that is used or intended to be used to modify or explore physiological systems or pathological status for the benefit of the recipient”. The importance of drug is very well known in all Ayurvedic classics and it has been highlighted by Charaka in Chatushpada. The use of herbs as herbo-mineral preparation for the management of diseases along with Sanshodhan karma is an important and prime aspect of Ayurvedic Science . The ancient Ayurvedists in their treatises have presented various views and hypothesis regarding the innate qualities and therapeutic action of medicinal plants in health and disease condition . Selection of Trial Drug : Selection of trial drug was based on the basis of selection of the Panchakarma procedure. Here since Vaitarana Basti was selected, therefore the present study was aimed so as to understand the role of drugs of Vaitarana Basti in the management of Amavata. this procedure have been indicated in Chikitsa Sutra described by Chakradatta. Acharya Chakradatta opines that the drugs having Deepana-Pachana properties and Katu Rasa dominant should be used for the management of Amavata. Many drugs have been mentioned in classics having above properties. Keeping above view in mind, some drugs namely “. Rasonadi Kwath, Shiva Guggul & Amrit manjari rasa were described in Bhaishajya Ratnavali (B.R. 29/23,94-98,136-139) were also selected as Shamana Yoga” . These drugs are well known for having analgesic and antiinflammatory actions. Thus the combination as a whole was used as Shamana Yoga having Vata-kaphahara property. A. DRUGS FOR VAITARANA BASTI Vaitarana Vasti comprises of following drugs i.e. Saindhava, Guda (Jaggery), Chincha (Tamarindus), Gomutra, Tila Taila. (Chakradutt- Niruhadhikar-73/32) 94 Drug Review SAINDHAVA (Rock Salt) Latin name : Soodium Chloride Chemical Formula: Nacl Synonyms : Sheetshiv, manimantha,sindhuj Pharmacodynamics : Rasa : Lavana, Madhura Virya : Sheeta Guna : Snigdha, Tikshna, Sukshma Vipaka : Madhura Doshaghnata : Tridoshahara Pharmacological Action : It has got Deepana and Vrishya properties in small doses, it is highly carminative and digestive. Saindhava plays the role of carrier and help to reach the Basti Dravya at microcellular level. It also helps to return the Basti Dravya in time. GUDA (JAGGERY) It is dark, coarse, unrefined sugar, sometimes referred to as “Palm Sugar”. It can be made either from the sap of various palm trees or from sugarcane juice. It is primarily used in India, where many categories of sugar made from sugarcane as Jaggery and that processed from palm trees as “Gur”. Jaggery has a sweet wine like fragrance and flavor that lends to distinction to whatever food it embellishes. Ayurvedic Review : Jaggery is explained under the heading of Ikshu Varga in all the Samhita, Nighantu. It is prepared by the juice of sugarcane when sugarcane juice is heated up to thick and somewhat hard then it is termed as Guda. According to Ch. Su. 27/289, before the formation of jaggery, the sugarcane juice undergoes three stages viz. – 1) Chaturbhaga-vasheshita - 1/4 remain 2) Tribhaga-vasheshita - 1/3 remain 3) Ardhabhaga-vasheshita - 1/2 remain These three varieties are called “Kshudra Guda” and they are light for digestion in their ascending order. 95 Drug Review Dhauta Guda : The finally formed Guda that is clean and of good quality is called Dhauta Guda and is used for medicinal purpose as well as dietetic purpose. Pharmacodynamics : Rasa : Madhura Guna : Snigdha, Ushna Virya : Ushna Vipaka : Madhura Doshaghnata : Tridosha Shamaka (According to Anupana). Chemical Constituents of Guda : The good quality jaggery contains moisture 3.6%, sucrose 6.85%, invert sugar 1015%, ash 2.5%, protein 4%, mineral matter 6%, calcium 80 mg/100gm, phosphorus 40mg/100gm, iron 11.4mg/100gm. It also contain carotene, vitamin A, Thiamine 0.02mg, Nicotinic acid 10mg/100gm. Properties : Deepana, Pachana, Anulomana, Vrishya, Mutra-Raktashodhaka increases Medodhatu, Kapha and Krimi, Pittaghna, Vatashamaka and its efficacy is considered to increase after one year (Su. Su. 45/160-161). Properties of Nava Guda (New Jaggery) : Newly prepared jaggery is Kapha, Swasa-Kasa Krita, Krimikara and Agnideepaka. Preparation of Purana Guda : It is Laghu, Pathya, Anabhishyandi, Agnivardhaka, Vata-pittaghna, Madhura, Vrishya, Rakta Prasadana. Modern Review : It is rich in minerals, iron and instant glucose. It is not only easily digestible but has various minerals and vitamin in right proportion, which is extremely useful for our body. Jaggery and sugar not only differ in their composition but also in their effect on human metabolism. 96 Drug Review CHINCHA Latin Name : Tamarindus indicus Family : Leguminaceae Synonyms : Rason, lasun, ugragandha. Pharmacodynamics : Rasa : Madhura, Amla Virya : Ushna Guna : Ruksha, Sara Vipaka : Amla Dosha Karma : Vata Shamaka Parts Used: Fruits, Leaf Chemical Constituents : Hordenine, c-glycosides (leaves), polysaccharides contained, galactose, xylose, arabinose, cardenotide, uzarigenin-3-o-beta D-xylopyranosyl, tartaric acid, citric acid, oxalic acid, amino acid – praline and pipecolinic acid, tamarindinal. Pharmacological Activities : Anti-inflammatory, immunomodulatory, antioxidative activity are well exhibited by the plant. (Database of Indian Medicinal Plant, C.C.R.A.S.). GOMUTRA (Cow's urine) Pharmacodynamics : Rasa : Katu, Madhura Anurasa Guna : Laghu, Ruksha, Tikshna : Lavana Vipaka : katu Virya : Ushna Doshaghnata: Tridoshaghna Pharmacological Activity : It is Agnideepaka, Visha-nashaka and useful for Asthapana Basti and Virechana. It is also useful in disease like Krimi, Udara Roga, Gulma, Anaha, Mukha Akshi Roga, Arsha, Pandu, Kandu, Kustha, Kilasa, Vata Vyadhi, Kasa and Madhumeha. Gomutra pacify Kapha by Katu Rasa, Katu Vipaka, Ushna Virya and Laghu Ruksha Tikshna Guna. It may act as Vatanulomaka due to its Madhura Rasa and Ushna Virya. It is useful for Asthapana Basti because of its Tridoshahara, Agni Deepana, Pachana, Srotovisodhana and Vatanulomana properties. 97 Drug Review COMPOSITION OF GOMUTRA Nitrogen N2 Lactose C6H12O6 Sulphur S Water H2O Ammonia NH3 Creatinine C4H8N2O2 Copper Cu Iron Fe Urea CO(NH2)2 Uric acid C4H4N4O3 Phosphate P Carbonic acid HCOO4 Manganese Mn Hippuric acid CHO-NH-CH2-COOH (Ref. Indian Agriculture Research Institute) TILA TAILA (Sesamum oil) Latin Name : Sesamum indicum Linn. Family : Pedaliaceae Synonyms : Alpatil, Vanyatil Pharmacodynamics : Rasa : Madhura, Kashaya, Tikta Virya : Ushna Guna : Guru, Snigdha Vipaka : Madhura Doshaghnata : Vatashamaka Chemical Constituents : Sesame seed contain fixed oil (50-60%), Carbohydrate (19-25%), protein (1626%), calcium (1.0-1.5%), phosphorus, mucilage (4%), woody fiber (4%). Liquids of fat consisting of oleic and lineoliec and (12-14%) of solid fat. It also contains crystalline substance sesamine and phenyl compound sesamol. Action : This drug subside Vata Dosha. It is Tvachya, Vedana Sthapana, Balya, Vrishya and Shulaprashaman. Seeds are laxative emollient and demulcent, diuretic, nourishing, lactogogue and emmenagogue. It relieves aching pain in head, ears and female organs generation (yoni) act as purifying agents in respect of the uterus and prove curative in urticaria. The use of sesamum oil is recommended in case of cut, cleft, punctured, severed, lacerated, blistered, thrashed or contused wounds and ulcers. Also in burns and scalds whether due 98 Drug Review to the application of heat or any vesicant alkaline solution as well as in bite of wild beasts and birds etc. and act beneficially in baths, unguents and lubrication Pharmacological Action : Sneha – because of qualities like Ushma, Tikshna, Vyavayi and Sukshma, reaches up to the microchannel levels, liquefies the morbid/viscid Kapha or Dosha for easy elimination. Because of Snigdha property it protects the intestinal mucosa from irritative substances. Because of Brimhana property it increases the tone and strength of the cells in whole body and intestinal mucosa particular. It decreases flatulence and increases general metabolism. Acharya Charaka has mentioned that Tila Taila is best among the Dravya in pacification of Vata. Taila alleviates Vata, but at the same time doesn’t aggravate the Kapha. It promotes the strength. It is beneficial for skin, Ushnaghna, Yuktam, Sthirikarana (provides firmness) and Yonivishodhanam. From therapeutic point of view another gravity of Tila Taila is when treated with other drugs, it also takes the property of that drugs. B. DRUGS OF RASONADI KWATHA Rasonadi kwath comprises of following drugs – Rasona, Sunthi, Nirgundi. RASONA Latin Name : Allium sativum linn. Family : Liliaceae Synonyms : Rason, Lasun, Ugragandha. Pharmacodynamics: Rasa :Madhura, Lavana, katu, tikta, Kasaya Guna : Snigdha, tiksna, picchil, sara Veerya : Usna Vipaka: Katu Parts Used: Rhizome Chemical Constituents :-moisture – 62.0; protein – 6.3; fat – 0.1; fibre – 0.8; carbohydrates – 29.8; and minerals – 1.0 gm/100gm. Calcuim – 30.0; phosphorus – 310.0; iron 1.3; thiamine – 0.06; riboflavin – 0.23; niacin – 0.4; and vitamin c – 13.0 mg/100gm. Its cal val is 145 k cal/100 gm. (nutritive value of indian foods – 85) : glutamyl peptides isolated from garlic are almost identical with those present in onion; 99 Drug Review they include : glutamyl – phenylalanine, : glutamyl – s – methylcysteine, : glutamyl – s : : carboxy : : methyle – ethyle cysteinylglycine, s – allylmercapto – l – cysteine and : l – glutamyl – s – allylmercapto – l – cysteine . (chem abstr, 1962). The amino acids present in the bulbs are leucine, methionine, s – propyl – l – cysteine; (: ) – s – propenyl – l – cysteine; s – methyl – cysteine; s – allyl – cysteine; s – allyl – cysteine sulphoxide (alliin); s – ethyl : l – cysteine sulphoxide (mp 166 : 67) and s – butyl – l – cysteine sulphoxide (mp 158 : 60). The presence of an enzyme, allinase is reported; by the action of allinase on alliin, allicin (thio – 2 – propene – 1 – sulfinic acid – s – allyl ester) is formed. The other sulphoxides present in the bulbs showed the same allinane splitting activity as that of alliin. The bulbs contain a thio glycoside, made up of a new amino acid and a carbohydrate, calcium fructuronate. Its aglycone kills escherichia coli. Scordine and scordinines a1, a2 and b have been isolated. An anthocyamin, cyanidin – 3 – glucoside is also present. The bulbs, on steam distillation, yield 0.06 – 0.1 precent of an essential oil having a brownish yellow color and a disagreeable garlic odour. The oil contains allyl alcohol, allyl propyldisulphide, methylallyldisulphide, diallyldisulphide, dimethyltrisulphide, methylallyl trisulphide, diallyltrisulphide and two unidentified compounds. Actions : vatahara, Kapha samaka,Sothahara, vedanasthapana, medhya, dipana, pacana, anulomana, bhagnasandhaniya, krmighna. Pharmacological Actions: Incorporation of garlic in the diet at moderate levels is likely to shift the balance of the microflora in the intestines in favour of lactic organisms, which generally have a favourable effect on the absorption of minerals present in the diet. Scordine is reported to possess fungicidal and anti – microbial activity. Garlic is an effective long: term preventive treatment for all rheumatic and catarrhal conditions. It produces anti: inflammatory activity.5: allyl cysteine sulphoxide exhibited anti: diabetic activity in alloxan diabetic rats. In a dose of 200 mg/kg body weight it decreased significantly concentration of serum lipids, blood glucose and activities of serum enzymes like alkaline phosphatase, acid phosphatase, liver and intestinal hmg coa reductase activity and liver hexokinase activity were increased significantly. C.g. sheela and k.t. augusti department of biochemistry, thiruvananthapuram 695 581 kerala. 100 university of kerala kriavattom Drug Review On oral administration of onion (allium cepa) and garlic (a.sativum) sulfoxide amino acids viz. S: methylcysteine sulfoxide (smcs) and s: allylcysteine sulfoxide (sacs) to alloxan: diabetic rats for a month, their diabetic condition, being characterised by glucose intolerance, weight loss, depletion of liver glycogen, etc. Was ameliorated as comparable to rats treated with glibenclamide and insulin. However, only the last two drugs significantly increased the conversion of labelled acetate to liver cholesterol which indicates a deterrent effect of the allium products against the synthesis of a risk factor. (c.g. sheela, kumud kumari and k.t. augusti, department of biochemistry, university of kerala, thiruvananthapuram kerala). SUNTHI Latin Name : Zingiber officinale Family : Zingiberaceae Synonyms : Nagara, Mahaoushada, Sonth, Vishwabheshja Pharmacodynamics : Rasa : Katu Guna Virya : Ushna : Laghu, Snigdha Vipaka : Madhura Doshaghnata : Kapha-vata Shamaka Parts Used : Rhizomes Chemical Constituents : It contains 0.25 to 3.0% of volatile oil possessing the aroma. The drug contains in additional resin and about 56% of the starch. The crude fiber varies from 1.7% to 9.0% with an average of 4.0%. The vitamins present in green ginger are Thiamine 0.06%, Riboflavin 0.03%, Niacin 0.06% and Vitamin C 6.0 mg/100 gm, the carotene present in 40 mg/100gm. The essential oil derived from dried ginger is greenish to yellow in color, mobile with characteristic aromatic odor. The oil contains sesquiterpene hydrocarbons (50% or more). Sesquiterpene alchoals, mesoterpenoids and associated compounds, esters of acetic and carbolic acids and a trace of phennol. Action: Deepana, Pachana, Shoolaprashamana, Shothahara, Vedanastapana, Ama Pachana, Raktashodaka, Vrishya. 101 Drug Review Therapeutic uses: Aruchi, Agnimandya, Ajirna, Ama Vata, Kasa, Shwasa Pharmacological Activities : Z. officinale has been molluscicidal effect possessing efficacy t control the parasites infection viz. schistosomiasis U. S. food and drug administration has included Zingiber as a product that is generally regarded as safe (GRAS). Ginger is used as an aromatic, carminative, stimulant and flavouring agent ginger oil is used in mouth washes. In additional medicine, it is used extensively for its specific action in rheumatism, carminative, anti-inflammatory activity. (Sevaranjan V.V. & Indira Balachandran). Zingiber officinale, according to ethno botanical data. It is being used by tribal and other ethnic groups for rheumatic diseases. (Jain SK Ethno Botany, V7(1,2) 83-88). Zingiber officinale exhibited marked anti-inflammatory activity in rat as compared to pridinisolone. (Sharma AK, Singh RH. 1980) Clinical study made by Singh et al and Joshi 1987 proved that Zingiber reduce cholesterol level considerably in hyper-cholesterolemia in rats. (Griji J et al Inaidn J., Nutri. Def. (12) 433, 436). Japanese herbalist Nabory Muramoto describes the traditional Japanese treatment of spinal and joint problems with ginger oil in his book “Healing ourselves”. In Tibetan medicine, ginger is regarded as promoting overall circulation of energy in the body (Goea and Shander Welss, Growing and Using of Healing Herbs, 147) NIRGUNDI Latin Name : Vitex nigundo Family : Verbenaceae Synonyms : Sephali, Sindhuvara, Sindhuka,Subha Pharmacodynamics : Rasa : Tikta, Katu, Kashaya Guna : Laghu, Ruksha Virya : Ushna Vipaka : Katu Parts Used: Leaf , roots, fruits 102 Drug Review Chemical Constituents : The fresh leaves of the plant yields a pale green yellow oil on steam distillation. The main constituents of the oil are aldehyde, ketone, phenolic derivative and cineol. Other alkaloids present are nishindine and hydrocotylene, glucononitol P-hydroxy benzoic acid, 3 – 6 dihydroxy benzoic acid, flavones, vitamin C and carotene are also found. Action: Vataghgna, jwaraghna, mutrajanan, artavajanan, shothaghna, rasayan. It is beneficial for eyes and ears. Flowers of nirgundi having property to destroy bacteria(jantu) (B.P.Guduchyadi verga). Therapeutic uses: Vishaghna, Krimighna , It is having action against pain, inflammation, Amavata, Krimi, Kustha, Aruchi, Kaphajawara. Pharmacological action : It is well known drug having analgesic, anti-inflammatory activities and is useful in acute rheumatism. The leaves are used in febrile condition and in puerperal state. Ethyl acetate extract of leaves of Vitex negundo produced anti-inflammatory effect against carragenin bradykinia and 5-HT induced rat hind paw edema. The extract exhibited significant anti-inflammatory effect on subacute, chronic and immunological studies. A compound isolated form V. negundo leaves showed significant antiinflammatory property on acute inflammation. The seed extracts were found less potent than leaf extract. Ether and saline extracts of the leaves exhibited antibacterial effect against staphylococcus aurous and E. coli infection. Butanol extract of root possessed antiinflammatory and analgesics effect. Pet, ether, butanol, chloroform extract of root and leaf produced antispasmodic effect. C. DRUGS OF SHIVA GUGGUL Shiva guggul comprises of following drugs –Haritki, Bibhitka, Amalki,Eranda tail, Guggul, Gandhak, Rasna,Vidanga, Maricha, Pippali, Danti, Jatamansi, Shunthi, Devadaru(Bh.Ratnavali-Aamvat rogaadhikar Pg-136-139) 103 Drug Review HARITAKI Latin Name: Terminalia chebula Family : Combretaceae Synonyms : Abhaya, Pathya , Shiva, Amrita, Harad, Chebulic myrobalan Pharmacodynamics: Rasa: Pancarasa except Lavana (Kasaya pradhana) Veerya: Usna Guna: Laghu, Ruksa Vipakaa: Madhura Dosaghnata :Tridosa Part Used : Fruit Chemical Constituents : Anthraquinone, glycoside, chebulinic acid, chebulagic acid, tannic acid, terchebin, tetrachebulin, Vit. C, arachidic, behenic, linoleic, oleic, palmitic and stearic acids (fruit kernel), chebulin (flowers); 2--hydroxy micromeric acid, maslinic acid and 2--hydroxy urosolic acid (leaves). Actions: Fruits are astringent, sweet acrid, bitter, sour, thermogenic, anodyne, antiinflammatory, vulnerary, alterant, stomachic, laxative, purgative, carminative, digestive, anthelmintic, dentrifice, cardiotonic, aphrodisiac, antiseptic, diuretic, febrifuge, depurative and tonic. They are useful in wounds and ulcers inflammation, skin diseases, leprosy, stomatitis, hyperacidity and associated gastric disorders, anorexia, indigestion, flatulence, constipation, haemorrhoid, jaundice, hepato-splenomegaly, other abdominal diseases, helminthiasis, anaemia, delirium, pharyngitis, hiccough. Pharmacological Activities : Antimicrobial, antifungal, antibacterial, antistress, antispasmodic, hypotensive, indurance, promoting activity, anti-hepatitis B virus activity, hypolipidaemic, inhibitory activity, against HIV-I protease, anthelmentic, purgative. Substitutes and Adulterants : T-citrina Roxb. found in the foothills of Himalayas from Nepal eastwards to Assam is called Haritaki in Bengali language and its fruits have medicinal properties similar to that o T-chebula. Hence they are used medicinally as those of T-chebula. - Antimicrobial against aspergillus Niger. - It is having healing property by decrease in breaking strength. 104 Drug Review BIBHITAKA Latin name Family : Terminalia bellirica : Combretaceae Synonyms : Karshaphala, Aksha, Kalidrum, Bheda, Belliric myrobalan Pharmacodynamics: Rasa : Kashaya Guna : Ruksha, Laghu Virya : Ushna Vipaka : Madhura Doshaghnata : Tridosha Shamaka (Vishesha Kapha Shamaka) Part Used: Fruit, seed, bark Chemical Constituents : Chebulagesic acid, ellagic acid and its ethyl ester, gallic acid, fructose, galactose, glucose and its galroyl derivative, mannitol, and Rhamnose, sitosteroll and ballericacin, protein and oxalic acid (seed); oxalic acid and tannin (bark); palmitic, oleic and linoleic acids (kernel and its oil). Actions : The bark is mildly diuretic and is useful in anaemia and leucoderma. Fruits are astringent, acrid, sweet, thermogonic, anti-inflammatory, anodyne, styptic, narcotic, digestive, anthelmintic, aperient, expectorant, ophthalmic, antipyretic, anti-emetic, and rejuvenating. They are useful in cough, asthma, bronchitis, pharyngitis, insomnia, dropsy, dyspepsia, flatulence, dipsia, vomiting, cardiac disorders, haemorrhage, ophthalmic disorders, strangury, splenomegaly, cephalagia, skin diseases, leprosy, fevers, ulcers and general debility. The mature and dry fruit is constipating and is useful in diarrhea and dysentery. Pharmacological Activities antihistaminic, activity : against Purgative blood pressure depressant, antifungal, viral hepatitis, and vitiligo, antiasthamatic, bronchodilatory, antispasmodic, antibacterial, anti-stress and endurance promoting activity. Substitutes And Adulterants : The bark of Terminalia bellirica Roxb. is used as adulterant to bark of T-arjuna. The fruits of T-belerica are reported to be used as substitute in tanning industry for T-chebula. 105 Drug Review Antimicrobial Component : - 7-hydroxy 3, 4-methylenedioxy flavan - 2, 3 – bis – (4 – hydroxyl benzyl – 1), amolignan B. Amolignan B was reported to have HIV – I reverse transcriptase inhibitory activity. (Phytomedicine V 3(suppl. 1) P – 181, 1996/97) AMALAKI Latin name : Embilica officinalis Family : Euphorbiaceae Synonyms : Dhatri, Amalaki, Amala, Indian Gooseberry Pharmacodynamics: Rasa :Pancha Rasa (Lavana Varjita), Amla Pradhana Guna : Guru, Ruksha, Sheeta Virya : Sheeta Vipaka : Madhura Doshaghnata : Tridosha Shamaka (especially Pitta Shamaka) Part Used : Fruit , root, bark, leaf Chemical Constituents: Fruit contains gallic acid, tannic acid, sugars, albumin, cellulose and minerals. The fruit is one of the richest natural sources of vitamin C, containing up to 720 mg/100g of fresh pulp and 921 mg/100cc of pressed juice. Other contents are as follows: Moisture 81.20, protein 0.5, fat 0.1, minerals 0.7, fibre 3.4, carbohydrate 14.1, calcium 0.05, phosphorus 0.02 % and iron 1.2 mg, nicotinic acid 0.2 mg per 100gms. of fruit. Actions :Dahaprashamana, Chakshushya, Keshya, Medhya, Rochana, Deepana, Anulomana, Vrishya, Rasayana, Pramehagana, Yakrutautejaka. Therapeutic uses: Prameha, Hridroga, Yakritroga, Kustha, Raktapitta. Pharmacological Actions: Fresh fruit is diuretic and laxative. Fruit is also carminative and stomachic. Dried fruit is sour and astringent. The dried fruit is used as a decoction to treat ophthalmia when applied externally, and is used internally as a haemostatic and antidiarrheal (Nadkarni 1954, 482). Both the fresh juice and crushed seeds are combined 106 Drug Review with Haridra as an effective treatment for diabetes (Sharma 2002, 327; Dash and Junius 1983, 90) ERANDA TAIL: It is extracted from the seeds of Eranda. ERANDA: Latin name Family Synonyms : Ricinus communis : Euphorbiaceae : Gandarva hasta, Panchangula, Vyagrapucha, Readi, Andi Pharmacodynamics : Rasa : Madhura, (Anurasa- Katu,Kashaya) Guna : Snigdha, Tikshna, Sukshma Virya : Ushna Vipaka : Madhura Doshaghnata : Kapha-Vata Shamaka Part Used: Seeds Chemical Constituents: Seeds contain moisture 5.1-5.6%, protein 12-16%, oil 4550.6%, N- free extr. 3.1-7-0, crude fibre 23.1-27.2% & ash 2-2.2%. Globulins constitute c-60% of the total proteins in the seed. It also contains high phosphorus content, phospholipids 0.12%, uric acid, HCN, minerals, resins, an alkjaloid- Ricinine & a viscous dark green oil, enzymes- lipase, amylase, invertase, catalase, peroxidase & reductase.Castor oil consists principally of Ricinoleic acid which occurs to the extent of 90% & is responsible for high viscosity. Stearic, oleic, linoleic & dihydroxystearic acid are also present in small quantities. Tocopherols, beta-Sitosterol etc. are also present. Actions (Karma): Shitahara, Vedanasthapana, Deepana Bhedana, Amashodhana, Amapachana. Therapeutic uses: It is useful in Katishoola, Gradhrasi, Amavata Pakshghata, Kampavata, Udararoga, Gulama, Arsha, etc. Pharmacological Actions: it is widely used as a cathartic and also for lubrication & illumination. The strong laxative property of castor oil is reported to be due to the local irritant action caused in the intestine by the Ricinoleic acid formed by the hydrolysis under the influence of the lipolytic enzymes. The motor activity of the bowel is 107 Drug Review stimulated, without much griping & the hastened peristalsis permits little time for the absorption of water from the intestinal contents. Copious liquid stools are produced in the 6 hrs. after of the oil. The unhydrolysed oil is washed out & hence the drug automatically limits its action. Pure Ricinoleic acid & its esters have also cathartic action. Frequent use of castor oil may produce severe intestinal irritation & deficiency states. Fatal dose (human beings):- 2.5- 6 seeds Principal toxic substance is the albumin, ricin. (The wealth of India) GUGGUL Latin Name : Commiphora Mukul Family : Burseraceae Synonyms : Guggulu, Palankash, Mahishaaksha, Pura, Kalaniryasa, Kaushik,Gugal, Gubdee, Gum, Guggul, Indian bedellium, Hill mango Pharmacodynamics: Rasa: Tikta Katu Guna: Laghu, Ruksha, Tikshan, Vishada, Sukshma, Sara, Virya: Ushna, Vipaka: Katu, Doshghanta: Part used Tridoshahara, : Latex (Gum exudates) Chemical Constituents :It contains 6 - 10 % moisture, Volatile Oil, Gum consists of alpha pinane, Myrcene, Eugeneol, Cadinine, Giraniol, Methyl hepetazone, Lymonene, Methyl thavicol. Guggulu contain guggulu sterone which is it's main active principle.Guggulu sterone activate lipolytick enzymes in plasma, liver and stimulates receptor mediated catabolisiom of LD. It inhibits hepatic cholosterol biosynthesis increases faecal Bile acid, secretion and enhances plasma, lecithin-cholestrol, acyl-tranferase activity. Action: Lekhana, Ropana, Vedana Sthapana, Nadibalya,Deepana, Saraka, Mutrala, Raktavardhaka,Rasayana. It increases W.B.C. count and haemoglobin. It is stimulant, kills microorganisms (Rogajantughna). It is blood purifier (Raktashodhaka) so it is used in Gonorrhoea. 108 Drug Review Therapeutic uses: Udararoga ,Urustambha , Shodhan, Karnadaurgandhya, Shwasa , Krimi, Vato-udara, Pliha, Shopha,Arsha,Gridhrasi, Krosthushirsha, Vidradh, Amlapitta, Vrana, Bhagandara Pharmacologial Action: Hypolipidamic,Hypocholesteremic, Antibecterial, Antiarthritic, Antiinflammotory, Anti atheroschlerotic. GANDHAK Latin name : Sulphur Chemical Formula :S Synonyms : Kushthari, Kitaghna, Pamari , Baali, Pharmacodynamics: Rasa: Madhu Guna: Snigdha, Tikshan Virya: Ushna, Vipaka: Katu, Doshghanta: Tridoshahara Actions: Kandu, Kushtha, Visarpa, Dadru, Tvakdosa, Amadosa, Visadosa, Krimidosa, Pliharoga, Amajirna, Mandagni, Netraroga, Ksayaroga etc Therapeutic uses: According to Rasa Ratna Samuchchaya, Gandhaka is said to be useful in Kandu, Kushtha, Visarpa, Dadru, Tvakdosa, Amadosa, Visadosa, Krimidosa, Pliharoga, Amajirna, Mandagni, Netraroga, Ksayaroga etc. It is also said to be Vishahara, Deepana and Rasayana. However, in Ayurvedic texts we do not find the detailed description of the pharmacological action of Gandhaka. (R. R. S. 3/16) Pharmacological Actions: It increases the production of bile & has a laxative, diuretic & germicidal effect. Internal administration in small quantities acts as a stimulant to secretary organs & is excreted in the sweat, milk & urine. It has specific action on the rectum & increases the haemorrhoidal secretions on large doses it acts as a purgative. ACTION ON THE DIGESTIVE SYSTEM Since the Sulphur is Deepana, Pachana, Yakriduttejaka and Pittasaraka, it performs the above actions. It is converted in to Sulphide form at intestines, and increases the peristalsis and as such it acts as a mild laxative. Sulphur causes soft defecation 109 Drug Review without any pain. It acts as germicide also. Prolonged use of Sulphur may produce dyspepsia and colitis. Owing to the above pharmacological actions, sulphur is very commonly used in Agnimandya, Ajeerna, Shoola, intestinal parasitic infestation etc. ACTIONS ON THE CIRCULATORY SYSTEM Sulphur is Rakta Sodhaka and as such it is very commonly used in Rheumatism, Rheumatoid Arthritis etc. blood related disorders. ACTIONS ON THE SKIN Sulphur is stated to be Kushthaghna and as such it is used in Kushtha, Visarpa, Vicharchika and various other skin diseases in individual form or in the form of some combinations. ASSIMILATION : Sulphur is absorbed as Rasayana, Vishaghna and Yogavahi. Owing to such absorption it is used in general debility. In lead poisoning sulphur is used as antidotes because it prevents the absorption of the lead in the intestines. EXTERNAL ACTIONS: When mixed with some greasy substance and applied on the skin, it gets converted into sulphide form which is a mild irritant and acts as anti pruritus (Kandhughna) and anti parasitic (Krimighna). RASNA Latin Name : Pluchea lanceolata Family : Compositae Synonyms : Yukta, Rasna, Elaparani, Raysan , Lesser Galangal Pharmacodynamics: Rasa: Tikta Guna: Guru Virya: Ushna Vipaaka: Katu Doshaghnataa: Kapha, Vaata Part used Prabhaava: Vishaghna : Root Chemical Constituents : The aerial parts contain five new terpenic glycosides viz. linaloyl glucoside, methyl-apiosyl-glucoside, 9-hydroxylinaloyl plucheosides A and B besides 15 known compounds. 110 glucoside and Drug Review The roots contain a new glycoside, plucheoside C, three new eudesmane-type sesquiterpenes, plucheols A and B and plucheoside E and three new lignan glycosides, plucheosides D1, D2 and D3 (Uchiyama et al, Phytochemistry, 1989, 28, 3369; 1991, 30, 655). In a recent investigation, quertecin and isarhamnetin were identified in the air dried leaves (wealth of India). Actions: Shothahara, Sheetahara, Vedanashamaka, Amapachaka, CNS disease, inflammation, toothache. It is mainly used in disease similar to rheumatoid arthritis. A decoction of the plant has been reported to prevent the swelling of joints in experimental arthritis. Therapeutic uses: Jwaraghna, vishaghna, vrishya, rasayana, kasa shwasahara. Pharmacological Action : This drug has two primary actions Acetylcholine like action and smooth muscle relaxant action on different muscle preparation. Petroleum ether extract of roots showing 45.5% anti-inflammatory activity. Sorghumol and chloroform soluble fraction of methanolic extract showing 54.5% antiinflammatory activity (M.A.P.A. 9102 – 1006 – Chawla, Chandrigarh). Extract of stem and leaves of pul. Exhibited 31.9% and 54.5% antioedema activity with petroleum ether extract and chloroform soluble portion of methanolic extract respectively. On fractionation, these extracts yielded moretenol acetate, moretenol, neolupenol in addition to other aliphatic compounds (M.A.P.A. 9105 – 2939 Chawla Chandigarh) Recent study: The methanol fraction of Pluchea indica Less root extract (PIRE) produces significant anti-inflammatory activity against glucose oxidase-induced paw edema (in vivo), inhibits hydroxyl radical and superoxide generation, lysis of erythrocytes induced by hydrogen peroxide, CCl(4)-induced lipid peroxidation and also dioxygenase activity of lipoxygenase (both in the presence and absence of hydrogen peroxide). (Sen T et, al Phytother Res. 2002 Jun;16(4):331-5) Pluchea indica Less root extract (PI-E) has effect on locomotor activity and pentobarbital-induced sleep, social isolation-induced aggressive behavior, motor 111 Drug Review coordination in the rotarod test, pentylenetetrazole-induced convulsion and nociceptive responses in the tail-pinch test (Thongpraditchote S et, al Biol Pharm Bull. 1996 Mar;19(3):379-83) VIDANGA Latin name : Embelia ribes Family : Myrsinaceae Synonyms : Chitratandula, Jantunashan, vishanashan, Krimighna Pharmacodynamics: Rasa : Virya : Ushna Doshaghanta : Part used : Katu Guna : Laghu, Ruksha, Tikshna Vipaka : Katu Kapha Vatahara Fruit Chemical Constituents :Embelin (2.5 –3 %), Christembine, Qvasritala (1 %), Tannin. Action: Deepana, Pachana,Shothahara , Shirovirechana Therapeutic uses: Krimighna, Triptighna, Kushthaghna, , Pharmacological action : Vidanga having + grade (+ = mild active), as per “the antibacterial activity of some Ayurvedic drugs.” (Jour. Res. Ind. Med. 9:2, 1974 page 65).Embelia ribes having anti-bacterial effect, as per “A complication, rational basis of the use of medicinal plants in skin disease” (Indian drugs 35(1) Jan. 1998).Zutshi U,Sharma SC et al;Embelia ribes is reported to be an effective analgesic. (Pharmacology,1990;40:179) Chitra,M.Devi,C.S.et al;Embelin is reported to have antitumour & anti-microbial and analgesic activity.(Indian J.Med.Sci.Res.,1994,22:87) MARICHA Latin name : Piper nigrum Family : Piperaceae Synonyms : Maricham, Hapusha, Ushanam, Golamiricha, Black pepper Pharmacodynamics: Rasa : Katu 112 Drug Review Guna : Laghu, Tikshna Virya : Ushna Vipaka : Katu Doshaghnata : Vata -Kapha Shamaka Part Used: Fruit Chemical Constituents: It contains a volatile alkaloid Piperine 5-9%, Piperdine 5%, a balsamic volatile essential oil 1-2%, fat 7%, masocarp contains Chavicin, a balsamic volatile oil, starch, lignin, gum, fat 1%, proteids 7% and containing organic matter 5%. Actions : Deepana, Pachana, Krimiagana, Kusthagana, Pramathi. Therapeutic uses: Agnimandya, Ajirna, Kasa, Shwasa, Adhamana, Skin diseases, Jawara. Pharmacological actions-Effect of piperine on pentobarbitone induced hypnosis in rats.[Mujumdar AM, Dhuley JN, Deshmukh VK, Raman PH, Thorat SL, Naik SR.Laboratory of Pharmacology and Toxicology, Hindustan Antibiotics Ltd, Pimpri, Pune, India.]Piperine (1-peperoyl piperidine), a major alkaloid isolated from Piper nigrum Linn, potentiated pentobarbitone sleeping time in dose dependant manner, with peak effect at 30 min. Blood and brain pentobarbitone levels were higher in piperine treated animals. Piperine treatment in rats, treated chronically with phenobarbitone, significantly potentiated pentobarbitone sleeping time, as compared to the controls.Effect of co-administration of piperine on pharmacokinetics of beta-lactam antibiotics in rats.[Hiwale AR, Dhuley JN, Naik SR.Research and Development Division of Hindustan Antibiotics Limited, Pimperi, Pune 411 018, India.] Co-administration of piperine, an alkaloid isolated from Piper nigrum L. enhanced bioavailability of beta lactam antibiotics, amoxycillin trihydrate and cefotaxime sodium significantly in rats. Permeability characteristics of piperine on oral absorption--an active alkaloid from peppers and a bioavailability enhancer.[Khajuria A, Zutshi U, Bedi KL.Isotope Section, Regional Research Laboratory, Jammu-Tawi, India.]Piperine, [1-[5-[1,3-benzodioxol-5yl]-1-oxo-2,4, pentadienyl] piperidine], is a pungent alkaloid present in Piper nigrum Linn, and P. longum Linn. It is shown to enhance the bioavailability of various structurally and therapeutically diverse drugs. A concise mechanism responsible for its bioavailability enhancing action is poorly understood. Data thus obtained suggested that 113 Drug Review piperine is absorbed very fast across the intestinal barrier. It may act as an apolar molecule and form apolar complex with drugs and solutes. It may modulate membrane dynamics due to its easy partitioning thus helping in efficient permeability across the barriers. Aromatic, Acrid, Hot, Carminative, antiperiodic. Piperine is a mild antipyretic & antiperodic.(K. M. Nadkarni Indian Materia Medica, Pg. No. 969, Vol-1,3rd edition) PIPPALI Latin name : Piper longum Family : Piperaceae Synonyms : Maagadhi, Vaidehi, Krishna, Kanaa, Chapala, Ushna, Upkulyaa, Tikshnatandulaa. Pipal, Pipali, Long Pepper Pharmacodynamics: Rasa : Katu Guna : Laghu, Snigdha, Tikshna Virya : Anushna Sheeta Vipaka : Madhura Doshaghnata : Vata-Kapha Shamaka Part Used: Fruit Chemical Constituents: Resins, volatile oil, starch, gum, fatty oil, inorganic matter & an alkaloid, Piperine 1- 2%. Actions: Deepana, Shirovirechana, Medhya, Raktashodhaka, Mootral, Vrishya, Rasayana. Therapeutic uses: Aruchi, Agnimandya, Gulma, Yakrutroga, Krimi, Raktavikara, Kasa, Shwasa, Hikka, Kustha. Pharmacological actions: This drug is effective in the treatment of the diseases of Pranavaha srotas(Abhang R1994,Anshuman P.S et.al 1984),effective in Giardiasis(Agarwal A.K.et al 1994),anti allergic(Dahanukar S.A et al 1984),Immuno stimulatory(Tripati D.M et al 1999),effective in asthma(Upadhyaya et.al 1982),Anti 114 Drug Review pyretic(Singh et al 1973),analgesic(Singh et al 1973),anti inflammatory (Singh et al 1973). Co-administration of piperine, an alkaloid isolated from Piper nigrum L. enhanced bioavailability of beta lactam antibiotics, amoxycillin trihydrate and cefotaxime sodium significantly in rats. Permeability characteristics of piperine on oral absorption--an active alkaloid from peppers and a bioavailability enhancer.[Khajuria A, Zutshi U, Bedi KL.Isotope Section, Regional Research Laboratory, Jammu-Tawi, India.]Piperine, [1-[5[1,3-benzodioxol-5-yl]-1-oxo-2,4, pentadienyl] piperidine], is a pungent alkaloid present in Piper nigrum Linn, and P. longum Linn. It is shown to enhance the bioavailability of various structurally and therapeutically diverse drugs. A concise mechanism responsible for its bioavailability enhancing action is poorly understood. Data thus obtained suggested that piperine is absorbed very fast across the intestinal barrier. It may act as an apolar molecule and form apolar complex with drugs and solutes. It may modulate membrane dynamics due to its easy partitioning thus helping in efficient permeability across the barriers. This Rasayana drug is useful in Pranavaha srotodushti Vikaras as per the classical references (Ch.Chi 1/pa-3/34-35) and is quite useful in Pinasa (B.P). DANTI Latin name : Baliospermum Montenum Family : Euphorbiaceae Synonyms : Udumbaraparni, Eranda phala, Shighra Pharmacodynamics: Rasa : Katu, Guna : Guru, Tikshna Virya : Ushna Vipaka : Katu Doshaghnata : Kapha Pittahara, Part used : Seeds & roots Chemical Constituents: Resin, Croton oil, Starch Actions : Sothahara, Veedanasthapna, Pittasara, Virechan, Krimighna Pharmacological Actions: Jalodar,Kamla,gulma, arsha, jwara, twak vicar, shwas roga, ashmari, sarpa visha. 115 Drug Review JATAMANSI Latin Name : Nardostaychyus Jatamansi Family : Valerianaceae Synonyms : Mansi, Jatila, Tamsi, Sulomasha, Indian spikenard, Balcchad Pharmacodynamics: Rasa : Tikta Guna : laghu,Snigdha Virya :Sheeta Vipak: Katu Doshaghanata : Tridoshahar Part used Prabhava: Manasdoshnashak : Root Chemical Constituents: : 2% Volatie oil containing on unidentified Ester an alchol, two Alkaloids. (Bose et al - 1957). It also contain Resine, Sugar,Stracha.'Jatamansicacid', Jatamansone & Nardostachys Ketones. It also countains Oroselol, Oroselone, Anagelic acid , Dehydrojatamansion. Actions:Balya,Medhya,Kantiprada,Bhutangana,Vishahara, Dahaprashamana Therapeutic uses: Sangyasthapana , Nidrajanana , Shamaka , Pittasaraka ,Hriday Niyamaka , Reduce blood pressure. Pharmacological actions :The oil free Aqueous of Nardostaychus Jatamansi showed a transient hypotencive effect & ECG changes in dog heart. (sheatn & kekre - 1956) Various extract of Jatamansi roots showed both sedative action in rats & revealed by physical in activation and potentiol of Phelobarbitone Sobium slepping time in rats & the hypotonsive activity in rates ( Gupta et al 1966) The oil was tried on case of Neurocirculatory Asthenia & related Cardiac condition like functional Cardiac Neurosis, Cardiac Arrythamias, Menopausal-Syndromes, Hypertensive states etc. showed encouraging results perticularly with respect to improvement in subjective parameters. (Vakil & Dalal) It is also useful in Epilepsy, Hysteria, Palpitation of Heart, Hypertensive, Diuretic,Antihistaminic,Anti-arrhythmic, Sedative. SHUNTHI Already described 116 Drug Review DEVDARU Latin Name :Cedrus devdaro Family :Pinaceae Synonyms :Daru, indradaru, mastdaru, kilim, devdar, pinus Pharmacodynamics: Rasa: Tikta, katu Guna: Veerya: Ushana Part used Laghu snigdha Vipaka: Katu : Patra, Tail, Kanda Chemical Constituents: : An alcaloid resin known as kelankatel and dark coloured oil or tar resembling crude turpentine are found. Actions : Kapha -Vatashamak, Bacteriocidal, Healing, Analgesics, Appetizer, Digestant, laxative, Cardio stimulant. Therapeutic uses: The woody portion is carminative, diaphoretic and diuretic. It is used in fever, flatulence, dropsy, urinary disease. Renin and turpentine are used externally in skin diseases. Pharmacological Actions: Phirang, Amavata, shleepad, shiroshool, kushtha, karnashool C. DRUGS OF AMRIT MANJARI RASA Amrit manjari rasa has comprises of the following drugs- Hingul, Visha(Vatsanabha), Kana (Pippali), Maricha, Tankan, Jatikosh (Javitri), Jambir (Bhaisajya Ratnavali Aamvatrogadhikar-171-173) HINGUL Latin name : Sulphuretum hydrargyri Chemical name : mercury sulphide Chemical formula:Rasodbhava, hanspada, lohghna, darad, churna parad, Shuktunda, cinnabar Pharmacodynamics: Rasa :Tikta, kashaya, kashay Guna :Snigdha Virya :Ushna Vipak :Madhur Doshaghnata :Tridoshaghna 117 Drug Review Action: Deepan, aampachak, virshya, & vishaghna, deha-bal-buddhi-vardhan Therapeutic: Netrarogaghna, kushthaghna, kamla, pleeharoga, hallas, aamvat, premeha, jwar, urustambha, klaibya, sarvaroga, pakshaghat har etc. VATSANABHA Latin name : Aconitum ferox Family : Ranunuculaceae Synonyms : Vatsanabha,Amrit,Visha, Bachanaga,Meetha Visha Monk’s hood Pharmacodynamics: Rasa : Madhur Guna : Laghu, Tikshna,Vyavayi,Vikasi Virya : Ushna Vipaka : Madhur Doshaghnata : Vata –Kapha Shamaka Part Used: Root Chemical Constituents: Actions: Shothahara, Vednasthapan, Uttejak, Rochan, Deepan, Swedajanan, Krimighna, Pachan, Therapeutic uses: Aamvathar,Girdhrasihar, Sandh-vatahar, Shirashulhar,Udarvikar, Agnimandya, Shula, Nasta artava, Shukrameha,Kushthaghna, Krimighna. Ajirna, Shwas, Jwara PIPPALI -Already described MARICHA -Already described 118 Drug Review TANKAN Chemical name : Sodium pyroborate Chemical Formula : Na2 B4O7.10H2o0 Synonyms : Tanka, Tanga, Lohashoshodhan, Saubhagya, Kshar raj, Sitakshara, Suhaga, Borex Pharmacodynamics: Rasa :Katu Guna :Tikshna Ruksha,Sarak Virya :Ushna Doshaghnata:Vatashamak Actions: Kaphasarak, Vishhara, Aartavajanan, Tvakdosahar, Amadoshaha, Krimidosahar, Aadhamanhar,Yakrituttejak etc Therapeutic uses: According to Rasa Rasa Tarangni, Tankan is said to be useful in Kandu, Kushtha, Shwas,Kasa,Varnahar,Mutra roga ,Netra roga,Karnasrava,Hridroga. etc. JAVITRI Latin name : Myristica fragrans Family : Myristicaceae Synonyms : Jatiphal,Jatikosha,Maltiphal, Jayphal, Nutmegtree Pharmacodynamics: Rasa : Tikta,Katu Guna : Laghu, Tikshna Virya : Ushna Vipaka : Katu Doshaghnata : Kapha-Vata Shamaka Part Used: Seed, Kosh(Javitri) Chemical Constituents: It’s seed’s contains a volatile essential oil 6-16%, Protein 7.5%, Starch14.6-24.2%, Minerals 1.7% and Javitri contain volatile essential oil 4-15%, Pectin , Amylodectran are 25% . Its volatile essential oil contain myristicin ,myristic acid D-Paineen,D-Kaphein,Ujinol etc. 119 Drug Review Actions: Shothahara, Vednasthapan, Uttejak, Durgandhhara, Kitaghana, Kusthaghana, Pramathi. Therapeutic uses: Agnimandya, Ajirna, Vistambha,Atisar,Ghrahani, Adhamana, ,Jawara Skin disease,Anidra. JAMBIR Latin name Family Synonyms : Citrous limon : Rutaceae : Jambir, dantshtha, jambu, Jambiri nibu, the lemon of India Pharmacodynamics: Rasa : Amla Guna : Guru, Tikshna Virya : Ushna Vipaka : Amla Doshaghnata : Kapha-Vata Shamaka, Pittavardhak Part Used: Fruit, Bark,Leaf Chemical Constituents: It’s fruit contains a yellowish volatile essential oil and nimbuka acid etc. Actions: Rochan, Deepan, Krimighna, Pachan, Anuloman, Pittasarak. Therapeutic uses:Agnimandya, Aruchi, Trishna, Vaman, Shula, Vibandha,Krimighna. Ajirna, Shwas, Kasa . 120 Drug Review THE PROFILES OF INGREDIENTS OF VAITRANA VASTI S.No. Ingredients 1. Saindhav Rasa Guna Virya Vipaka Doshaghnata Lavan,Madhur Snighdha,Tikshna, Sheet Madhura Tridoshaghna Ushna Madhura Tridoshaghna (Sodium chloride) 2. Guda Sukshama Madhur Snighdha,Ushna (Jaggery) 3. Chincha (acc. to anupan) Madhur,Amla Ruksha,Sara Ushna Amla Vata Shamak Katu Laghu, Ushna Katu Tridoshaghna Ushna Madhur Vata shamaka (Tamarindus indicus) 4. Go mutra (Cow Urine) 5. Tila tail (Sesamum Ruksha,Tikshna Madhur,Kashaya, Guru, Snighdha Tikta indicum) THE PROFILES OF INGREDIENTS OF RASONADI KWATH S.No. Ingredients 1. Rasona (Allium sativum) 2. Shunthi Rasa Guna Virya Vipaka Doshaghnata Madhur, Lavan , Snigdha,Tikshna, Ushna Katu Katu, Tikta,Kashaya Picchil,Guru Katu Snigdha,Laghu Ushna Madhur K-V Shamak Tikta,Katu, Kashaya Laghu,Ruksha Ushna Katu V –K Shamak (Zingiber officinale) 3. Nirgundi (Vitex nigundo) 121 Drug Review THE PROFILES OF INGREDIENTS OF SHIVA GUGGUL S.No. Ingredients 1. Hartiki 2. Rasa Guna Virya Vipaka Doshaghnata Ushna Madhura V –K Shamak , Pancha Rasa Laghu, (Terminalia (lavane Ruksha chebula) varjita) Bibhitki Kashaya tridoshaghna (mainly vatashamak) Ruksha, Laghu Ushna Madhura (Terminalia (mainly Kapha bellerica) 3. 4. Tridoshaghna shamaka) Amalki Pancha rasa Guru Ruksha (emblica (larana rahita) Seeta officinalis) amla pradhana Eranda tail Madhura (Ricinus Sheeta Madhura Tridosh shamak (mainly Pittashamak) Snigdha , Tikshna, Ushna Madhura K-V Shamak Ushna Katu K-V Shamak Sukshma communis) 5. Guggul Katu, Tikta (Commiphora mukul) 6. Gandhak Laghu, Ruksha, Tikshna, Vishada, Sukshma, Sara Madhura Tikshna, Snigdha Ushna Katu K-V Shamak Tikta Guru Ushna Katu K-V Shamak Katu, Kasaya Laghu, Ruksha, Ushna Katu K-V Shamak Ushna Katu Vata-kapha shamaka Anushna Madhura K-V Shamak (Sulphur) 7. Rasna (Pluchea lanceolata) 8. Vidanga (Embelia ribes) 9. Maricha Tikshna Katu (Piper longum) 10. Pippali Katu (piper longum) 11. Danti Laghu, Tikshna Laghu, Snighdha Tikshna Sheeta Katu Guru, Tikshna Ushna Katu K-P Shamak Tikta Laghu ,Snigdha Sheeta Katu Tridosha Shamak Katu Snigdha,Laghu Ushna Madhur K-V Shamak Tikta, Katu Laghu ,Snigdha Ushna Katu V-K Shamak (Baliospermum montenum) 12. Jatamansi (Nardostaychyus jatamansi) 13. Shunthi (Zingiber officinale) 14. Devadaru (Cedrus devdaro) 122 Drug Review THE PROFILES OF INGREDIENTS OF AMRIT MANJARI RAS S.No. Ingredients 1. Hingul (Murcury Rasa Guna Virya Vipaka Doshaghnata Tikta ,Kashaya, Snighdha Ushna Madhura Tridoshaghna Laghu,Tikshna, Ushna Madhura V-K shamaka Laghu, Snighdha Anushna Madhura K-V Shamak Tikshna Sheeta Katu Laghu, Tikshna Ushna Katu V-K shamaka Katu Tikshna,Ruksha,Sarak Ushna Katu Vata shamaka Tikta,Katu Laghu, Tikshna Ushna Katu V-K shamaka Amla Guru,Tikshna Ushna Amla K-V Shamak Katu sulphide) 2. Vatsnabha Madhur (Aconitum ferox) 3. Pippali Vyavayi, Vikasi Katu (piper longum) 4. Maricha (Piper longum) 5. Tankan (Sodium pyroborate) 6. Javitri (Myristica fragrans) 7. Jambir (Citrus limon) 123