Download Pharmacology_1

Modul 1.
Medical prescription. Pharmacology of agents affecting nervous system
Text test questions
1 Drug for general anaesthesia with the widest range of narcotic action
A Nitrous oxide
B Sombrevin
C Ethyl alcohol
D Thiopental
E Ether for anesthesia
ANSWER: E
2 Typical effect, which develops during introduction to ether anaesthesia
A Does not irritate mucous membranes
B does not cause myorelaxation
C Rapid development of anesthesia
D Absence of sleep after narcosis
E Protracted stage of excitation
ANSWER: E
3 The medicine for i.v. and i.m. anesthesia
A Ether for anesthesia
B Nitrous oxide
C Phthorothanum
D Propanidid
E Ketaminum
ANSWER: E
4 The preparation for inhalation anesthesia
A Natrii oxybutyras
B Sombrevin
C Ketamin
D Propanidid
E Nitrous oxide
ANSWER: E
5 Nitrous oxide is characterized by
A Proper myorelaxation
B Prolonged stage of excitation
C Mucous membrane irritation
D Deep anesthesia
E Expressed analgesia
ANSWER: E
6 Drug for general anesthesia, the derivative of barbiturates, which contains sulfur
A Nitrous oxide
B Aether pro narcosi
C Ketamin
D Sombrevin
E Thiopentalum
ANSWER: E
7 The duration of Propanidide action
A 3-5 hours
B 20-30 min.
C 0,5-1 hours
D 20-30 sec.
E 3-5 min.
ANSWER: E
8 The preparation used for insomnia
A Difenine
B Ethosuximidum
C Carbamazepine
D Ketaminum
E Nitrazepam
ANSWER: E
9 Diazepame main property which used for neurosis treatment
A Analeptical
B Narcotic
C Antipsychotic
D Anaesthetic
E Anxiolytic
ANSWER: E
10Phenobarbital main property
A Does not change the structure of sleep
B Stimulates psychical activity
C Does not cause accumulation
D Does not activate microsomal enzyme system
E Shortens the phase of rapid sleep
ANSWER: E
11The long-term phenobarbitale admininstration may cause
A Anaesthesia
B Tachyphylaxis
C Blockade of microsomal enzymes
D Analgesia
E Material accumulation
ANSWER: E
12Which preparation can markedly change the structure of sleep?
A Phenitoin
B Zopiclone
C Gidasepam
D Bromide
E Phenobarbital
ANSWER: E
13The preparation with somnolent and antihistaminic activity
A Phenobarbital
B Zopiclone
C Sibazone
D Nitrazepamum
E Dimedrolum
ANSWER: E
14Which preparation is effective for trigeminal neuralgia?
A Nitrazepamum
B Sibazone
C Bromide
D Phenobarbital
E Carbamazepine
ANSWER: E
15Typical side effect of diphenine (phenitoin), showing up in the cavity of mouth
A Dryness
B Hypersalivation
C Stomatitis
D Glossitis
E Gingival hyperplasia
ANSWER: E
16What is the drug for epilepsia treatment?
A Amitryptilin
B Magnesium sulfate
C Ketaminum
D Valeriana
E Carbamazepine
ANSWER: E
17Carbamazepine is applied for
A Improvement of mood
B For local anaesthesia
C Breathing stimulations
D General anesthesia
E Epilepsy treatment
ANSWER: E
18Which concentration of Ethyl alcohol solution for surgeon hands rinsing correlates
with proper antiseptic effect?
A 96%
B 40%
C 30%
D 10%
E 70%
ANSWER: E
19What Ethyl alcohol concentration for disinfection of surgical instruments?
A 70%
B 40%
C 76%
D 30%
E 96%
ANSWER: E
20Ethyl alcohol is used for inhalation at:
A Insomnia
B Allergy
C Oppressing of breathing
D Cardiac arrhythmia
E Pulmonary edema
ANSWER: E
21Why ethyl alcohol cannot be used for general anesthesia?
A Increases heat beating and renders a diuretic action
B Strong irritative action
C Absence of prolonged stage of analgesia
D Causes chronic intoxication
E Narrow therapeutic window and expressed stage of excitation
ANSWER: E
22Effect of Natrii oxybutyras
A Antipsychotic
B Analeptical
C Local anesthesia
D Psycho-motor stimulant
E Antihypoxic
ANSWER: E
23The drug used for Parkinson disease which affects dophaminergic processes in
CNS
A Cyclodolum
B Difenin
C Karbamazepinum
D Phenobarbital
E Levodopa
ANSWER: E
24Drug for Parkinson disease with the central cholinoblocking action?
A Levodopa
B Carbidopa
C Phenobarbital
D Nitrazepam
E Cyclodolum
ANSWER: E
25Levodopa effect at Parkinsonism is due to:
A Oppression of dophaminergic processes in CNS
B Stimulation of cholinergic processes in CNS
C Oppression of cholinergic processes in CNS
D Oppression of glutamatergic processes in CNS
E Stimulation of dophaminergic processes in CNS
ANSWER: E
26Cyclodolum is used for:
A Pain
B Anesthesia
C Epilepsia
D Insomnia
E Parkinson disease
ANSWER: E
27Property of Nitrous oxide which may be used in ambulatory dental practice for
tooth extraction:
A Drying
B Anesthetic
C Irritating
D Disinfecting
E Analgesic
ANSWER: E
28Coffeine is
A Antidepressant
B Nootropic drug
C Analgesic
D Anxiolytic
E Psycho-motor stimulant
ANSWER: E
29Preparation which belongs to analeptics
A Proserinum
B Lidocaine
C Adrenalini hydrochloridum
D Ketamini hydrochloridum
E Bemegridum
ANSWER: E
30Preparation which belongs to analeptics
A Piracetam
B Sydnocarb
C Natrii oxybutyras
D Amitriptyline
E Cordiaminum
ANSWER: E
31Basic pharmacological effect of analeptics
A Antidepressive
B Anti cough
C Dilation of vessels
D Memory increase
E Breathing stimulation
ANSWER: E
32Psychomotor stimulant
A Aethimizolum
B Bemegridum
C Cordiaminum
D Camphora
E Caffeine
ANSWER: E
33Analeptics indication
A Psychical depression
B Postoperative atony of the intestine
C Hypertension crisis
D Insomnia
E Oppressing of breathing
ANSWER: E
34The preparation used for respiratory and vasomotor centers stimulation is called
A Paracetamolum
B Proserinum
C Amitriptyline
D Morphinum
E Caffeine
ANSWER: E
35Nootropic drug (neurometabolic cerebroprotector)
A Caffeine
B Noradrenalinum
C Proserinum
D Cordiaminum
E Piracetam
ANSWER: E
36Caffeine action caused by excitation of brain stem center:
A Tranquilizer
B Improvement of memory
C Mental and physical capacity increase
D Tachycardia
E Breathing stimulation
ANSWER: E
37Antidepressant used for treatment of endogenous depressions (schizophrenia,
manic-depressive psychosis) is
A Proserinum
B Caffeine
C Bemegridum
D Sibazonum
E Amitriptyline
ANSWER: E
38Sulfocamphocainum is used
A For endogenous depression
B For rheumatism
C For arterial hypertension
D For tachyarrhythmias
E For medulla centers activation
ANSWER: E
39Caffeine is
A Analeptic and antidepressant
B Antidepressant and psychomotor stimulant
C Antidepressant and nootropic
D Analeptic and nootropic
E Analeptic and psychomotor stimulant
ANSWER: E
40Piracetamum nootropic activity reveals in
A Delirium and hallucinations
B Fear
C Fatigue
D Depression
E Improvement of studying and memory
ANSWER: E
41Coffeine is not used for cardiac insufficiency treatment due to its ability:
A To diminish oxygen consumption of myocardium
B To increase intensity of systole
C To diminish intensity of systole
D To cause bradycardia
E To increase oxygen consumption of myocardium
ANSWER: E
42Bemegridum is not applied at somnolent poisoning due to its ability:
A To promote excitability of neurons of CNS
B To stimulate the centers of brain stem
C To promote arterial hypertension
D To stimulate breathing
E To provoke cramps and hypoxia of CNS
ANSWER: E
43Mechanism of Cordiaminum stimulative influence on breathing:
A Direct action on respiratory center
B Reflex action on respiratory center
C Intensive contraction of respiratory muscles
D Intensive contraction of the diaphragm
E Mixed action on respiratory center
ANSWER: E
44Bronchial asthma attacks are relieved with:
A Noradrenalinum
B Mesatonum
C Anaprilinum
D Reserpine
E Salbutamolum
ANSWER: E
45Mechanism of Salbutamole bronchodilation action
A Stimulation alpha 1 – adrenoreceptors of the bronchi
B Stimulation of м – cholinoreceptors of the bronchi
C Blockage of м-cholinoreceptors of the bronchi
D Blockage beta 2 - adrenoreceptors of the bronchi
E Stimulation beta 2 - adrenoreceptors of the bronchi
ANSWER: E
46Mechanism of Cytitonum stimulant influence on breathing
A Direct action on a respiratory center
B Mixed action on a respiratory center
C Intensive contraction of the intercostal muscles
D Intensive contraction of the diaphragm
E Reflex action on a respiratory center
ANSWER: E
47The expectorant of reflex action
A Acetylcysteinum
B Trypsinum
C Natrii hydrocarbonate
D Bromhexinum
E Thermopsis drugs
ANSWER: E
48Complications, arising up at codeine application as anti cough agent
A Dry mouth, insomnia
B Tachycardia, arrhythmia
C Tachypnoe, bronchospasm
D Increase of arterial pressure
E Constipation, medical dependence
ANSWER: E
49Bemegridum belongs to the group of
A Narcotic analgesics
B Non-narcotic analgesics
C Antidepressants
D Psychostimulants
E Analeptics
ANSWER: E
50Complication, arising up at the overdose of the Thermopsis herb extract
A Bronchial asthma
B Arrhythmia
C Bradycardia
D Dry mouth
E Vomiting
ANSWER: E
51Libexinum belongs to the group of
A Narcotic analgesics
B Non-narcotic analgesics
C Mucolytics agents
D Stimulators of breathing
E Anticough drugs
ANSWER: E
52Acetylcysteinum is used for treatment
A Hypertensive disease
B Ulcer disease
C Angina pectoris
D Arrhythmias
E Chronic bronchitis
ANSWER: E
53Cordiaminum is used for
A Bronchial asthma
B Hypertensive disease
C Bronchitis
D Gastritis
E Collapse
ANSWER: E
54Bromhexinum belongs to the group of:
A Non-narcotic analgesics
B Non-steroidal anti-inflammatory drugs
C Laxatives
D Analeptics
E Mucolytics
ANSWER: E
55Beta 2-adrenomimetics include:
A Nafthyzinum
B Adrenaline hydrochloridum
C Atropine sulfas
D Methacinum
E Salbutamolum
ANSWER: E
56Glucocorticoid used as inhalation for bronchial asthma treatment:
A Isadrinum
B Salbutamolum
C Euphyllinum
D Cromolinum-natrium
E Beclometazoni dipropionat
ANSWER: E
57Ketotifenum is used for:
A Constipation
B Pneumonia treatment
C Gastritis
D Angina pectoris
E Prophylaxis of bronchial asthma attack
ANSWER: E
58Mechanism of action of Cromolinum-sodium:
A Blockage of adenosine A alpha1- receptors in the bronchi
B Stimulation of beta2 - adrenoreceptors of the bronchi
C Blockage of beta2 - adrenoreceptors of the bronchi
D Blockage of M - cholinoreceptors of the bronchi
E Stabilisation of mast cells membranes and prevention release of allergy
mediators
ANSWER: E
59Local anesthetics affect:
A Cortex of cerebrum
B Thalamus
C Limbic system
D Proteins of superficial layer of mucous membranes and skin
E Endings of sensitive nerves and nerve fibers
ANSWER: E
60The action of local anesthetics is:
A Increase of permeability of cellular membranes for calcium ions
B Oppressing of pain impulses in the spinal cord
C Oppressing of pain impulses at thalamus
D Activating of the endogenous antinociceptive system
E Decrease of permeability of cellular membranes for sodium ions
ANSWER: E
61Local anesthetic of the ether group (according to chemical structure):
A Lidocaine
B Ultracaine
C Trimecainum
D Bupivacaine
E Novocainee
ANSWER: E
62How does action of local anesthetics change in the locus of inflammatory process?
A Does not change
B Increases
C Accelerates
D Lengthens
E Reduces
ANSWER: E
63Local anesthetic of the amide group (according to chemical structure):
A Cocaine
B Anaesthesinum
C Novocaine
D Dicainum
E Lidocaine
ANSWER: E
64Vasoconstrictive agents supplements to the solutions of local anesthetics results in:
A Acceleration of local anesthetic absorption
B Effect decreases
C Toxic effect increases
D Systemic action increases
E Prophylaxis of their resorbtive (systemic) action
ANSWER: E
65The group of drugs, which intensify and increase the duration of action of local
anesthetics:
A Analeptics
B alfa-adrenoblockers
C M-cholinomimetics
D N-cholinomimetics
E alfa-adrenomimetics
ANSWER: E
66The preparation used for all types of local anesthesia:
A Cocaine
B Dicainum
C Anaesthesinum
D Novocaine
E Lidocaine
ANSWER: E
67Lidocaine:
A Is used only for infiltrative and conductive anesthesia
B Is not used for anesthesia
C Is used only for superficial anesthesia
D Is used only for spinal anesthesia
E Is used for all kinds of local anesthesia
ANSWER: E
68Novocaine:
A Is used only for infiltrative anesthesia
B Is not a derivative of PABA
C Is not destroyed by cholinesterase
D May be combined with sulphonamides
E Often causes allergic reactions
ANSWER: E
69Neuroleptics are administered for:
A Neuroses
B Hyperkinesis
C Collapse
D Parkinson’s disease
E Psychoses
ANSWER: E
70The typical effect for all neuroleptics:
A Anti cough
B Expectorant
C Nootropic
D Psychostimulative
E Antipsychotic
ANSWER: E
71Neuroleptic, used for neuroleptanalgesia
A Aminazine
B Triftazine
C Levomepromazinum
D Haloperidol
E Droperidol
ANSWER: E
72Mechanism of myorelaxation of tranquilizers
A Oppress an acetylcholinesterase
B Block M-cholinoreceptors of smooth muscles
C Block N-cholinoreceptors of skeletal muscles
D Direct influence on myofibrils of skeletal muscles
E Oppress the central mechanisms of muscular tonus
ANSWER: E
73Mechanism of antipsychotic action of neuroleptics
A Blockade of cholinoreceptors in CNS
B Blockade of adenosine receptors in CNS
C Blockade of histamine receptors in CNS
D Activating of GABA-receptors in CNS
E Blockade of dopamine D2-receptors in CNS
ANSWER: E
74The typical effect of tranquilizers of benzodiazepine is:
A Antipsychotic
B Hypothermal
C Antivomiting
D M-cholinoblocking
E Anxyolitic
ANSWER: E
75The tranquilizer, applied for premedication before an operation
A Nitrazepam
B Haloperidol
C Droperidol
D Aminazine
E Diazepam
ANSWER: E
76Tranquilizer with the expressed somnolent action
A Codeine
B Aminazine
C Dimedrolum
D Ephedrine
E Nitrazepam
ANSWER: E
77The effect of Diazepamum:
A Antipsychotic
B Antivomiting
C Hypothermal
D M-cholinoblocking
E Anxyolitic
ANSWER: E
78The effect of Etaperazinum:
A Psychostimulative
B Provokes vomiting
C Hypertensive
D Spasmolytic
E Antivomiting
ANSWER: E
79The preparation, applied at neuroses
A Adrenalinum
B Isadrinum
C Cordiaminum
D Atropinum
E Sibazon
ANSWER: E
80The typical complication, developing after long-term administration of
Aminasinum and other neuroleptics
A Euphoria
B Increase of arterial pressure
C Vomiting
D Bradycardia
E Parkinsonism
ANSWER: E
81The typical complication, developing after prolonged usage of Diazepamum and
other tranquilizers:
A Extrapyramidal disorders
B Gastritis
C Bronchial asthma
D Arterial pressure increase
E Drug dependence
ANSWER: E
82Basic difference of neuroleptics from tranquilizers:
A Anticonvulsant properties
B Do not affect the vegetative nervous system
C Do not intensify the action of anesthesia drugs
D Cause tachyphylaxis
E Antipsychotic effect
ANSWER: E
83The tranquilizer is:
A Aminazine
B Morphine
C Droperidol
D Fentanyl
E Sibazon
ANSWER: E
84Aminazine, Droperidol belong to:
A Tranquilizers
B Antidepressants
C Analeptics
D Nootropic drugs
E Neuroleptics
ANSWER: E
85The mechanism of action of sodium bromide:
A Excitation of M-cholinoreceptors in the brain
B Intensifying processes of excitation in CNS
C Blockade of the histamine receptors in CNS
D Blockade of dopamine receptors in CNS
E Intensifying processes of depression in the brain
ANSWER: E
86Valerian and Motherwort preparations belong to the group:
A Tranquilizers
B Neuroleptics
C Sleeping-pills
D Anticonvulsant preparations
E Sedative preparations
ANSWER: E
87The symptoms of bromism (side effect of long-term bromides administration)
A Excitation of CNS, dryness of mucous membranes
B Constipation, stomach-ache
C Tachycardia, insomnia
D Nausea, vomiting
E Acne rashes, somnolence, rhinorhea
ANSWER: E
88The drug which after long-term administration causes phenomenon of bromism
A Sodium hydrocarbonate
B Sodium sulfate
C Sodium citrate
D EDTA (Trilonum B)
E Sodium bromide
ANSWER: E
89The plant with sedative action
A Lemon
B Thermopsis
C Foxglove
D Strophanthus
E Valeriana
ANSWER: E
90How do we mark the neuroleptics effect of removing delirium and hallucinations
A Antivomiting
B Sedation
C Hypothermal
D Myorelaxation
E Antipsychotic
ANSWER: E
91The main complication after neuroleptics administration
A Arterial pressure increase
B Bradycardia
C Drug dependence
D Euphoria
E Extrapyramidal disorders
ANSWER: E
92Neuroleptic which causes Parkinson syndrome due to its M-cholinoblocking
activity
A Rezerpine
B Aspirin
C paracetamol
D Etaperazin
E Aminazine
ANSWER: E
93Which preparation belongs to neuroleptics
A Chlozepid
B Sibazon
C Phenazepamum
D Nitrazepamum
E Aminazinum
ANSWER: E
94The excitation of benzodiazepine receptors is accompanied with:
A Antipsychotic effect
B Antivomiting effect
C Arterial pressure increase
D Arterial pressure decrease
E Anxiolytic effect
ANSWER: E
95Benzodiazepine tranquilizers intensify the action
A Psychomotor stimulants
B Analeptics
C Antidepressants
D Nootropic preparations
E General anesthetics, analgesics, somnolents
ANSWER: E
96Prolonged administration of tranquilizers is limited due to their ability to cause:
A Myorelaxation of central genesis
B Intensifying of analgesics action
C Somnolent effect
D Anticonvulsant effect
E Drug dependence
ANSWER: E
97What is the mechanism of indirect-action cholinergic stimulants action?
A Stimulate beta-adrenoreceptors
B Block of М-cholinoreceptors
C Block of monoaminooxidase
D Affect serotonine receptors
E Block of cholinesterase
ANSWER: E
98Patient entered the hospital neurological department with post-stroke syndrome.
What cholinergic medicine is the most expediently to the patient?
A Atropine
B Dipiroxim
C Salbutamol
D Aspirine
E Galantamine
ANSWER: E
99Patient with the acute stomachache, vomiting, heavy breathing, bronchospasm, was
delivered to the intensive therapy department. During examination of patient - skin
moisture, hypersalivation, myosis, bradycardia, muscular fascilation was noted. From
the anamnesis it is known, that patient – toxin abused person, used aerosols against
insects as abuse substance. What pharmacological group of agents the poisoning
substance belongs to?
A N- cholinomimetic
B М-choliniblockers
C Myorelaxants
D Ganglion-blockers
E Anticholinesterase agents
ANSWER: E
100 To patient with signs of poisoning by phosphor organic substance
cholinesterase reactivator was injected. Indicate a mechanism of action of this drug.
A Inactivation of cholinesterase
B Block of cholinoreceptors
C Activate of cholinoreceptors
D Oppression of acetylcholine synthesis
E Dephosphorilation of cholinesterase with renewal of its activity
ANSWER: E