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Modul 1. Medical prescription. Pharmacology of agents affecting nervous system Text test questions 1 Drug for general anaesthesia with the widest range of narcotic action A Nitrous oxide B Sombrevin C Ethyl alcohol D Thiopental E Ether for anesthesia ANSWER: E 2 Typical effect, which develops during introduction to ether anaesthesia A Does not irritate mucous membranes B does not cause myorelaxation C Rapid development of anesthesia D Absence of sleep after narcosis E Protracted stage of excitation ANSWER: E 3 The medicine for i.v. and i.m. anesthesia A Ether for anesthesia B Nitrous oxide C Phthorothanum D Propanidid E Ketaminum ANSWER: E 4 The preparation for inhalation anesthesia A Natrii oxybutyras B Sombrevin C Ketamin D Propanidid E Nitrous oxide ANSWER: E 5 Nitrous oxide is characterized by A Proper myorelaxation B Prolonged stage of excitation C Mucous membrane irritation D Deep anesthesia E Expressed analgesia ANSWER: E 6 Drug for general anesthesia, the derivative of barbiturates, which contains sulfur A Nitrous oxide B Aether pro narcosi C Ketamin D Sombrevin E Thiopentalum ANSWER: E 7 The duration of Propanidide action A 3-5 hours B 20-30 min. C 0,5-1 hours D 20-30 sec. E 3-5 min. ANSWER: E 8 The preparation used for insomnia A Difenine B Ethosuximidum C Carbamazepine D Ketaminum E Nitrazepam ANSWER: E 9 Diazepame main property which used for neurosis treatment A Analeptical B Narcotic C Antipsychotic D Anaesthetic E Anxiolytic ANSWER: E 10Phenobarbital main property A Does not change the structure of sleep B Stimulates psychical activity C Does not cause accumulation D Does not activate microsomal enzyme system E Shortens the phase of rapid sleep ANSWER: E 11The long-term phenobarbitale admininstration may cause A Anaesthesia B Tachyphylaxis C Blockade of microsomal enzymes D Analgesia E Material accumulation ANSWER: E 12Which preparation can markedly change the structure of sleep? A Phenitoin B Zopiclone C Gidasepam D Bromide E Phenobarbital ANSWER: E 13The preparation with somnolent and antihistaminic activity A Phenobarbital B Zopiclone C Sibazone D Nitrazepamum E Dimedrolum ANSWER: E 14Which preparation is effective for trigeminal neuralgia? A Nitrazepamum B Sibazone C Bromide D Phenobarbital E Carbamazepine ANSWER: E 15Typical side effect of diphenine (phenitoin), showing up in the cavity of mouth A Dryness B Hypersalivation C Stomatitis D Glossitis E Gingival hyperplasia ANSWER: E 16What is the drug for epilepsia treatment? A Amitryptilin B Magnesium sulfate C Ketaminum D Valeriana E Carbamazepine ANSWER: E 17Carbamazepine is applied for A Improvement of mood B For local anaesthesia C Breathing stimulations D General anesthesia E Epilepsy treatment ANSWER: E 18Which concentration of Ethyl alcohol solution for surgeon hands rinsing correlates with proper antiseptic effect? A 96% B 40% C 30% D 10% E 70% ANSWER: E 19What Ethyl alcohol concentration for disinfection of surgical instruments? A 70% B 40% C 76% D 30% E 96% ANSWER: E 20Ethyl alcohol is used for inhalation at: A Insomnia B Allergy C Oppressing of breathing D Cardiac arrhythmia E Pulmonary edema ANSWER: E 21Why ethyl alcohol cannot be used for general anesthesia? A Increases heat beating and renders a diuretic action B Strong irritative action C Absence of prolonged stage of analgesia D Causes chronic intoxication E Narrow therapeutic window and expressed stage of excitation ANSWER: E 22Effect of Natrii oxybutyras A Antipsychotic B Analeptical C Local anesthesia D Psycho-motor stimulant E Antihypoxic ANSWER: E 23The drug used for Parkinson disease which affects dophaminergic processes in CNS A Cyclodolum B Difenin C Karbamazepinum D Phenobarbital E Levodopa ANSWER: E 24Drug for Parkinson disease with the central cholinoblocking action? A Levodopa B Carbidopa C Phenobarbital D Nitrazepam E Cyclodolum ANSWER: E 25Levodopa effect at Parkinsonism is due to: A Oppression of dophaminergic processes in CNS B Stimulation of cholinergic processes in CNS C Oppression of cholinergic processes in CNS D Oppression of glutamatergic processes in CNS E Stimulation of dophaminergic processes in CNS ANSWER: E 26Cyclodolum is used for: A Pain B Anesthesia C Epilepsia D Insomnia E Parkinson disease ANSWER: E 27Property of Nitrous oxide which may be used in ambulatory dental practice for tooth extraction: A Drying B Anesthetic C Irritating D Disinfecting E Analgesic ANSWER: E 28Coffeine is A Antidepressant B Nootropic drug C Analgesic D Anxiolytic E Psycho-motor stimulant ANSWER: E 29Preparation which belongs to analeptics A Proserinum B Lidocaine C Adrenalini hydrochloridum D Ketamini hydrochloridum E Bemegridum ANSWER: E 30Preparation which belongs to analeptics A Piracetam B Sydnocarb C Natrii oxybutyras D Amitriptyline E Cordiaminum ANSWER: E 31Basic pharmacological effect of analeptics A Antidepressive B Anti cough C Dilation of vessels D Memory increase E Breathing stimulation ANSWER: E 32Psychomotor stimulant A Aethimizolum B Bemegridum C Cordiaminum D Camphora E Caffeine ANSWER: E 33Analeptics indication A Psychical depression B Postoperative atony of the intestine C Hypertension crisis D Insomnia E Oppressing of breathing ANSWER: E 34The preparation used for respiratory and vasomotor centers stimulation is called A Paracetamolum B Proserinum C Amitriptyline D Morphinum E Caffeine ANSWER: E 35Nootropic drug (neurometabolic cerebroprotector) A Caffeine B Noradrenalinum C Proserinum D Cordiaminum E Piracetam ANSWER: E 36Caffeine action caused by excitation of brain stem center: A Tranquilizer B Improvement of memory C Mental and physical capacity increase D Tachycardia E Breathing stimulation ANSWER: E 37Antidepressant used for treatment of endogenous depressions (schizophrenia, manic-depressive psychosis) is A Proserinum B Caffeine C Bemegridum D Sibazonum E Amitriptyline ANSWER: E 38Sulfocamphocainum is used A For endogenous depression B For rheumatism C For arterial hypertension D For tachyarrhythmias E For medulla centers activation ANSWER: E 39Caffeine is A Analeptic and antidepressant B Antidepressant and psychomotor stimulant C Antidepressant and nootropic D Analeptic and nootropic E Analeptic and psychomotor stimulant ANSWER: E 40Piracetamum nootropic activity reveals in A Delirium and hallucinations B Fear C Fatigue D Depression E Improvement of studying and memory ANSWER: E 41Coffeine is not used for cardiac insufficiency treatment due to its ability: A To diminish oxygen consumption of myocardium B To increase intensity of systole C To diminish intensity of systole D To cause bradycardia E To increase oxygen consumption of myocardium ANSWER: E 42Bemegridum is not applied at somnolent poisoning due to its ability: A To promote excitability of neurons of CNS B To stimulate the centers of brain stem C To promote arterial hypertension D To stimulate breathing E To provoke cramps and hypoxia of CNS ANSWER: E 43Mechanism of Cordiaminum stimulative influence on breathing: A Direct action on respiratory center B Reflex action on respiratory center C Intensive contraction of respiratory muscles D Intensive contraction of the diaphragm E Mixed action on respiratory center ANSWER: E 44Bronchial asthma attacks are relieved with: A Noradrenalinum B Mesatonum C Anaprilinum D Reserpine E Salbutamolum ANSWER: E 45Mechanism of Salbutamole bronchodilation action A Stimulation alpha 1 – adrenoreceptors of the bronchi B Stimulation of м – cholinoreceptors of the bronchi C Blockage of м-cholinoreceptors of the bronchi D Blockage beta 2 - adrenoreceptors of the bronchi E Stimulation beta 2 - adrenoreceptors of the bronchi ANSWER: E 46Mechanism of Cytitonum stimulant influence on breathing A Direct action on a respiratory center B Mixed action on a respiratory center C Intensive contraction of the intercostal muscles D Intensive contraction of the diaphragm E Reflex action on a respiratory center ANSWER: E 47The expectorant of reflex action A Acetylcysteinum B Trypsinum C Natrii hydrocarbonate D Bromhexinum E Thermopsis drugs ANSWER: E 48Complications, arising up at codeine application as anti cough agent A Dry mouth, insomnia B Tachycardia, arrhythmia C Tachypnoe, bronchospasm D Increase of arterial pressure E Constipation, medical dependence ANSWER: E 49Bemegridum belongs to the group of A Narcotic analgesics B Non-narcotic analgesics C Antidepressants D Psychostimulants E Analeptics ANSWER: E 50Complication, arising up at the overdose of the Thermopsis herb extract A Bronchial asthma B Arrhythmia C Bradycardia D Dry mouth E Vomiting ANSWER: E 51Libexinum belongs to the group of A Narcotic analgesics B Non-narcotic analgesics C Mucolytics agents D Stimulators of breathing E Anticough drugs ANSWER: E 52Acetylcysteinum is used for treatment A Hypertensive disease B Ulcer disease C Angina pectoris D Arrhythmias E Chronic bronchitis ANSWER: E 53Cordiaminum is used for A Bronchial asthma B Hypertensive disease C Bronchitis D Gastritis E Collapse ANSWER: E 54Bromhexinum belongs to the group of: A Non-narcotic analgesics B Non-steroidal anti-inflammatory drugs C Laxatives D Analeptics E Mucolytics ANSWER: E 55Beta 2-adrenomimetics include: A Nafthyzinum B Adrenaline hydrochloridum C Atropine sulfas D Methacinum E Salbutamolum ANSWER: E 56Glucocorticoid used as inhalation for bronchial asthma treatment: A Isadrinum B Salbutamolum C Euphyllinum D Cromolinum-natrium E Beclometazoni dipropionat ANSWER: E 57Ketotifenum is used for: A Constipation B Pneumonia treatment C Gastritis D Angina pectoris E Prophylaxis of bronchial asthma attack ANSWER: E 58Mechanism of action of Cromolinum-sodium: A Blockage of adenosine A alpha1- receptors in the bronchi B Stimulation of beta2 - adrenoreceptors of the bronchi C Blockage of beta2 - adrenoreceptors of the bronchi D Blockage of M - cholinoreceptors of the bronchi E Stabilisation of mast cells membranes and prevention release of allergy mediators ANSWER: E 59Local anesthetics affect: A Cortex of cerebrum B Thalamus C Limbic system D Proteins of superficial layer of mucous membranes and skin E Endings of sensitive nerves and nerve fibers ANSWER: E 60The action of local anesthetics is: A Increase of permeability of cellular membranes for calcium ions B Oppressing of pain impulses in the spinal cord C Oppressing of pain impulses at thalamus D Activating of the endogenous antinociceptive system E Decrease of permeability of cellular membranes for sodium ions ANSWER: E 61Local anesthetic of the ether group (according to chemical structure): A Lidocaine B Ultracaine C Trimecainum D Bupivacaine E Novocainee ANSWER: E 62How does action of local anesthetics change in the locus of inflammatory process? A Does not change B Increases C Accelerates D Lengthens E Reduces ANSWER: E 63Local anesthetic of the amide group (according to chemical structure): A Cocaine B Anaesthesinum C Novocaine D Dicainum E Lidocaine ANSWER: E 64Vasoconstrictive agents supplements to the solutions of local anesthetics results in: A Acceleration of local anesthetic absorption B Effect decreases C Toxic effect increases D Systemic action increases E Prophylaxis of their resorbtive (systemic) action ANSWER: E 65The group of drugs, which intensify and increase the duration of action of local anesthetics: A Analeptics B alfa-adrenoblockers C M-cholinomimetics D N-cholinomimetics E alfa-adrenomimetics ANSWER: E 66The preparation used for all types of local anesthesia: A Cocaine B Dicainum C Anaesthesinum D Novocaine E Lidocaine ANSWER: E 67Lidocaine: A Is used only for infiltrative and conductive anesthesia B Is not used for anesthesia C Is used only for superficial anesthesia D Is used only for spinal anesthesia E Is used for all kinds of local anesthesia ANSWER: E 68Novocaine: A Is used only for infiltrative anesthesia B Is not a derivative of PABA C Is not destroyed by cholinesterase D May be combined with sulphonamides E Often causes allergic reactions ANSWER: E 69Neuroleptics are administered for: A Neuroses B Hyperkinesis C Collapse D Parkinson’s disease E Psychoses ANSWER: E 70The typical effect for all neuroleptics: A Anti cough B Expectorant C Nootropic D Psychostimulative E Antipsychotic ANSWER: E 71Neuroleptic, used for neuroleptanalgesia A Aminazine B Triftazine C Levomepromazinum D Haloperidol E Droperidol ANSWER: E 72Mechanism of myorelaxation of tranquilizers A Oppress an acetylcholinesterase B Block M-cholinoreceptors of smooth muscles C Block N-cholinoreceptors of skeletal muscles D Direct influence on myofibrils of skeletal muscles E Oppress the central mechanisms of muscular tonus ANSWER: E 73Mechanism of antipsychotic action of neuroleptics A Blockade of cholinoreceptors in CNS B Blockade of adenosine receptors in CNS C Blockade of histamine receptors in CNS D Activating of GABA-receptors in CNS E Blockade of dopamine D2-receptors in CNS ANSWER: E 74The typical effect of tranquilizers of benzodiazepine is: A Antipsychotic B Hypothermal C Antivomiting D M-cholinoblocking E Anxyolitic ANSWER: E 75The tranquilizer, applied for premedication before an operation A Nitrazepam B Haloperidol C Droperidol D Aminazine E Diazepam ANSWER: E 76Tranquilizer with the expressed somnolent action A Codeine B Aminazine C Dimedrolum D Ephedrine E Nitrazepam ANSWER: E 77The effect of Diazepamum: A Antipsychotic B Antivomiting C Hypothermal D M-cholinoblocking E Anxyolitic ANSWER: E 78The effect of Etaperazinum: A Psychostimulative B Provokes vomiting C Hypertensive D Spasmolytic E Antivomiting ANSWER: E 79The preparation, applied at neuroses A Adrenalinum B Isadrinum C Cordiaminum D Atropinum E Sibazon ANSWER: E 80The typical complication, developing after long-term administration of Aminasinum and other neuroleptics A Euphoria B Increase of arterial pressure C Vomiting D Bradycardia E Parkinsonism ANSWER: E 81The typical complication, developing after prolonged usage of Diazepamum and other tranquilizers: A Extrapyramidal disorders B Gastritis C Bronchial asthma D Arterial pressure increase E Drug dependence ANSWER: E 82Basic difference of neuroleptics from tranquilizers: A Anticonvulsant properties B Do not affect the vegetative nervous system C Do not intensify the action of anesthesia drugs D Cause tachyphylaxis E Antipsychotic effect ANSWER: E 83The tranquilizer is: A Aminazine B Morphine C Droperidol D Fentanyl E Sibazon ANSWER: E 84Aminazine, Droperidol belong to: A Tranquilizers B Antidepressants C Analeptics D Nootropic drugs E Neuroleptics ANSWER: E 85The mechanism of action of sodium bromide: A Excitation of M-cholinoreceptors in the brain B Intensifying processes of excitation in CNS C Blockade of the histamine receptors in CNS D Blockade of dopamine receptors in CNS E Intensifying processes of depression in the brain ANSWER: E 86Valerian and Motherwort preparations belong to the group: A Tranquilizers B Neuroleptics C Sleeping-pills D Anticonvulsant preparations E Sedative preparations ANSWER: E 87The symptoms of bromism (side effect of long-term bromides administration) A Excitation of CNS, dryness of mucous membranes B Constipation, stomach-ache C Tachycardia, insomnia D Nausea, vomiting E Acne rashes, somnolence, rhinorhea ANSWER: E 88The drug which after long-term administration causes phenomenon of bromism A Sodium hydrocarbonate B Sodium sulfate C Sodium citrate D EDTA (Trilonum B) E Sodium bromide ANSWER: E 89The plant with sedative action A Lemon B Thermopsis C Foxglove D Strophanthus E Valeriana ANSWER: E 90How do we mark the neuroleptics effect of removing delirium and hallucinations A Antivomiting B Sedation C Hypothermal D Myorelaxation E Antipsychotic ANSWER: E 91The main complication after neuroleptics administration A Arterial pressure increase B Bradycardia C Drug dependence D Euphoria E Extrapyramidal disorders ANSWER: E 92Neuroleptic which causes Parkinson syndrome due to its M-cholinoblocking activity A Rezerpine B Aspirin C paracetamol D Etaperazin E Aminazine ANSWER: E 93Which preparation belongs to neuroleptics A Chlozepid B Sibazon C Phenazepamum D Nitrazepamum E Aminazinum ANSWER: E 94The excitation of benzodiazepine receptors is accompanied with: A Antipsychotic effect B Antivomiting effect C Arterial pressure increase D Arterial pressure decrease E Anxiolytic effect ANSWER: E 95Benzodiazepine tranquilizers intensify the action A Psychomotor stimulants B Analeptics C Antidepressants D Nootropic preparations E General anesthetics, analgesics, somnolents ANSWER: E 96Prolonged administration of tranquilizers is limited due to their ability to cause: A Myorelaxation of central genesis B Intensifying of analgesics action C Somnolent effect D Anticonvulsant effect E Drug dependence ANSWER: E 97What is the mechanism of indirect-action cholinergic stimulants action? A Stimulate beta-adrenoreceptors B Block of М-cholinoreceptors C Block of monoaminooxidase D Affect serotonine receptors E Block of cholinesterase ANSWER: E 98Patient entered the hospital neurological department with post-stroke syndrome. What cholinergic medicine is the most expediently to the patient? A Atropine B Dipiroxim C Salbutamol D Aspirine E Galantamine ANSWER: E 99Patient with the acute stomachache, vomiting, heavy breathing, bronchospasm, was delivered to the intensive therapy department. During examination of patient - skin moisture, hypersalivation, myosis, bradycardia, muscular fascilation was noted. From the anamnesis it is known, that patient – toxin abused person, used aerosols against insects as abuse substance. What pharmacological group of agents the poisoning substance belongs to? A N- cholinomimetic B М-choliniblockers C Myorelaxants D Ganglion-blockers E Anticholinesterase agents ANSWER: E 100 To patient with signs of poisoning by phosphor organic substance cholinesterase reactivator was injected. Indicate a mechanism of action of this drug. A Inactivation of cholinesterase B Block of cholinoreceptors C Activate of cholinoreceptors D Oppression of acetylcholine synthesis E Dephosphorilation of cholinesterase with renewal of its activity ANSWER: E