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Intel® Teach Program Essentials Course Genetics Unit Plan Unit Author First and Last Name Andrea West School District Greenville County Schools School Name Wade Hampton High School School City, State Greenville, SC Unit Overview Unit Title Genetics Unit Summary The student will demonstrate an understanding of the molecular basis of heredity. Specifically, an understanding of the structure and function of DNA, the mechanism for passing traits from one generation to the next, and the advances in genetic engineering will be developed. Ultimately, students will apply their new knowledge by creating a research project on a chosen genetic disorder. Subject Area Biology Grade Level 9th and 10th grade Approximate Time Needed 10 – 90 minute classes Unit Foundation Targeted Content Standards and Benchmarks B-4.1 Compare DNA and RNA in terms of structure, nucleotides, and base pairs. B-4.2 Summarize the relationship among DNA, genes, and chromosomes. B-4.6 Predict inherited traits by using the principles of Mendelian genetics (including segregation, independent assortment, and dominance). B-4.7 Summarize the chromosome theory of inheritance and relate that theory to Gregor Mendel’s principles of genetics. B-4.8 Compare the consequences of mutations in body cells with those in gametes. B-4.9 Exemplify ways that introduce new genetic characteristics into an organism or a population by applying the principles of modern genetics. Student Objectives/Learning Outcomes Recall the major points of Mendel’s three laws of inheritance. Predict the ratios of traits in offspring based on the three laws of inheritance. Given parental phenotypes or genotypes, identify all possible gametes that could be produced. Be able to perform a Punnett square, both for a single trait (monohybrid) and two traits simultaneously (dihybrid). Identify traits as homozygous, heterozygous, dominant, or recessive. Understand the significance of linked genes. Use a pedigree to determine if a trait is dominant or recessive, and sex-linked or autosomal. Compare and contrast incomplete dominance with codominance. Understand how traits can be polygenic, have multiple alleles, or both. © 2008 Intel Corporation. All Rights Reserved. Page 1 of 5 Intel® Teach Program Essentials Course Recall the basic definition of a mutation, as well as some causes of mutation. Compare and contrast mutations in sex cells with those in somatic cells. Cite specific examples of genetic disorders that result from mutations, including both gene and chromosomal mutations. Understand the significant difference between different types of mutations, such as point mutations and deletions. Recall the basic processes behind genetic engineering and selective breeding Describe some of the benefits and drawbacks/dangers involved in genetic engineering and selective breeding. Understand the significance of genetic engineering to science, technology, and society. Curriculum-Framing Questions Essential How similar are children to their parents? Question Unit Questions How is genetic information passed from parent to offspring? How do mutations lead to genetic variation in a species? How is genetic engineering used to improve commercial products? 1. What are the differences between chromosomes, genes and alleles? 2. What is the difference between individuals who are homozygous or heterozygous for a trait? 3. Use a Punnett Square to predict genotypic and phenotypic ratios. Content Questions 4. How can you analyze a Pedigree to determine if a trait is dominant or recessive, and autosomal or sex-linked? 5. What is the Chromosomal Theory of Inheritance, and how does it explain complex patterns of inheritance? 6. What are the consequences of gene mutations and chromosome mutations? 7. What are the benefits and risks of genetic engineering? Assessment Plan Assessment Timeline Before project work begins Students work on projects and complete tasks After project work is completed Student Needs Assessment Ongoing Assessment Summative Assessment Pre-Test 10 question multiple choice quiz on USA TestPrep website Word Cloud Self-assessment and peer assessment Ongoing Assessment Project Post-Test Create a word Distribute Online survey Project Unit Test cloud with all of project rubric to choose topic submitted and the words you and monitor graded based Use support already know progress on scoring document that are related rubric (checklist) for Student to DNA and selfconference to heredity. Scale assessment assess the words to progress Peer make the top 5 assessment of most important rough drafts words bigger submitted to than the rest. class wiki © 2008 Intel Corporation. All Rights Reserved. Page 2 of 5 Intel® Teach Program Essentials Course Assessment Summary Students will be assessed at the beginning of the unit through an online pre-test on USATestPrep.com. Previous knowledge will also be assessed through the use of wordle.net, where students will display their understanding of genetics vocabulary by creating a word cloud. Students will be assessed both formally and informally throughout the unit with individual and small group practice, worksheets, and lab activities. Students can use the Genetic Disease Project Rubric to selfassess and monitor their own progress as they complete their research project. An online survey (surveymonkey.com) and individual student conferences will help to monitor student progress as they work on their project. Students will also provide peer feedback through a class wiki after viewing rough drafts of other students’ projects. At the end of the unit, students will be assessed with a Unit Test. The Genetic Disease Project will be graded according to the scoring rubric. Unit Details Prerequisite Skills Students are expected to have a basic understanding of genetics from 7th grade science. Previous knowledge includes the difference between dominant and recessive traits, genotype and phenotype, and the use of Punnett Squares. Students are also expected to recall the structure of nucleic acids (DNA and RNA) from the Energetics Unit, as well recall that DNA is located within the nucleus from the Cells Unit. Instructional Procedures DAY 1: Students will start by creating a DNA Wordle. They will brainstorm a list of words related to DNA and heredity, then create a word cloud using wordle.net. This activity can help assess prior knowledge. Next, I will present the Concept 1 Notes on DNA/RNA Structure (PPT). These notes will have a focus on the importance of DNA as the instructions to make proteins. Students will also differentiate between DNA, chromosomes, genes. DAY 2: Introduce Genetic Disease Project (Show student sample, 99 Balloons Video, Distribute Rubric) After introducing the Genetic Disease Project, I will present the Concept 2 Notes on Mendel’s Laws. We will practice applying the Law of Dominance with a Punnett Square worksheet. DAY 3: We will complete the Genotype Profile Activity, where students will identify genetic traits they have (ex. Chin dimple, Hitchhiker’s thumb, Widow’s Peak). Students will be asked to identify their phenotype and genotype for each of the traits. Students will then “mate” with other students in class to determine the possible phenotypes of their offspring. After the activity, I will show the students sample projects from past years. Students will sign up for a genetic disease to research for their project. DAY 4: We will complete the Pipe Cleaner Babies Lab, which will help students to visualize how genes are carried on chromosomes, and how the alleles can be passed on to offspring. Students will also learn about sex-linked traits, and will compare predicted phenotypic ratios (found by creating Punnett Squares) to actual phenotypic ratios (found by compiling class data). Students will enter their data into a class Google docs spreadsheet. © 2008 Intel Corporation. All Rights Reserved. Page 3 of 5 Intel® Teach Program Essentials Course DAY 5: We will finish the Pipe Cleaner Babies lab by completing analysis questions based on the compilation of class data. After completing the analysis questions, students will have the opportunity to research their chosen genetic disease, either online or using books borrowed from the library. At the end of class, students will complete a short online survey to monitor their progress. DAY 6: I will present the rest of the Concept 2 Notes on Complex Patterns of Inheritance, including Incomplete Dominance, Co-dominance, Multiple Alleles, and Polygenic Traits. We will practice identifying the type of inheritance. I will also introduce Pedigrees, and we will practice identifying the pattern of inheritance by viewing several sample pedigrees. DAY 7: I will present the Concept 3 Notes on Mutations. We will then watch a clip of the video “Cracking the Code” about Tay Sachs Disease. Students will have the opportunity to complete research for their genetic disease project, either online or using books borrowed from the library. I will monitor student progress with informal student conferences. At the end of class, students will be required to turn in four index cards with research related to the four main areas of their project (Doctor’s Report, Genetic Counselor’s Report, Parent’s Report, Community Report). Each index card must have at least one citation listed. DAY 8: I will present the Concept 3 Notes on Genetic Engineering. We will watch several video clips to show some of the new applications of modern genetics. Students will work with a partner to complete a Webquest activity. DAY 9: (First half of class) Students will submit a rough draft of their project. Students will provide feedback in small groups based on specific criteria. Each student will be assigned 2-3 other projects to view. They will then log in to the class wiki and make comments on those projects. Students will view their feedback and make changes as needed. (Second half of class) Review for Unit Test DAY 10: Genetics Unit Test Students who complete the test early may work on their project. (Any work that is not completed at this point will be completed by the student outside of class.) Accommodations for Differentiated Instruction Special Needs Students Follow guidelines as specified in the student’s IEP or 504 plan. Students will work with their Resource Teacher as needed throughout the unit. Students may have additional time during their resource class to research and compile their projects. © 2008 Intel Corporation. All Rights Reserved. Page 4 of 5 Intel® Teach Program Essentials Course Nonnative Speakers Gifted/Talented Students Nonnative speakers will work with their ESOL Teacher as needed throughout the unit. Depending on English proficiency, students may also complete assignments in their native language to be translated with the help of their ESOL Teacher. The final product that students create is open to interpretation and allows for the students to express their creativity. The difficulty level of the project can be adjusted based on the topic chosen and the medium used. Materials and Resources Required For Unit Technology – Hardware (Click boxes of all equipment needed) Camera Laser Disk VCR Computer(s) Printer Video Camera Digital Camera Projection System Video Conferencing Equip. DVD Player Scanner Other Internet Connection Television Technology – Software (Click boxes of all software needed.) Database/Spreadsheet Image Processing Web Page Development Desktop Publishing Internet Web Browser Word Processing E-mail Software Multimedia Class Wiki Encyclopedia on CD-ROM Printed Materials Nowicki, Stephen. Biology. Illinois: McDougal Littell: 2008. Various library books on genetic disorders Student Notes Packet (Unit Outlines, class notes in Cornell Notes format, lab/activity handouts) Supplies Pipe Cleaner Babies – student set (for 2 students) includes 6 pipe cleaners (8 white, 3 red, 1 blue) and 11 beads (3 yellow, 1 black, 2 blue, 2 orange, 2 purple, 1 white) USATestPrep – www.usatestprep.com Wordle Activity – www.wordle.net 99 Balloons YouTube Video - www.youtube.com/watch?v=th6Njr-qkq0 Internet Resources “Cracking the Code” Video - http://www.pbs.org/wgbh/nova/body/crackingthe-code-of-life.html Google Docs - https://docs.google.com/ Survey Monkey – www.surveymonkey.com Wiki – westbiology.pbworks.com Other Resources Programs of the Intel® Education Initiative are funded by the Intel Foundation and Intel Corporation. Copyright © 2007, Intel Corporation. All rights reserved. Intel, the Intel logo, Intel Education Initiative, and Intel Teach Program are trademarks of Intel Corporation in the U.S. and other countries. *Other names and brands may be claimed as the property of others. © 2008 Intel Corporation. All Rights Reserved. Page 5 of 5