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Summary SUMMARY Medical science has made considerable progress in various fields. Many of the ailments are thought of as ‘in curable’ such as arthritis. Statistical analysis has shown that a greater part of the population will have some forms of arthritis by the age of 60. Out of which the prevalence of RA is estimated to be 1.2%. systematic denunciate of such cures is being done through the new found audio-visual media. People are made to believe that constant use of aspirin and cortisone which give temporary relief from pain and whose continued use renders them in effective are the only way out. In fact there are serious side toxic effects as a result of prolonged use of these conventional drugs. In such condition the very trusted knowledge of Ayurveda which has proven its efficacy since thousands of years, was employed. Assessing the gravity and chronicity of the disease, Shaman Ausadha (Rasonadi Kwatha, Shiva Guggul, Amrit manjari Ras) & Shodhan (Vaitaran Vasti) present study titled “Cinical study to evaluate the efficacy of some herbomineral compounds and Vaitaran basti in cases of Aamvata with sero positive cases of R.A. positive cases of Rheumatoid arthritis” in the management of Amavata with the following Aims and objectives To study the pathogenesis of Aamvata. To evaluate the role of Shaman drug (Rasonadi Kwath, Shiva Guggul, Amrit manjari ras) in the disease Aamvata. To evaluate the role of Vaitarana Basti with Shaman drug (Rasonadi Kwath, Shiva Guggul) in the disease Aamvata. To assess the effect of Vaitarana Basti with Shaman drug (Rasonadi Kwath, Shiva Guggul, Amrit manjari ras) in Aamvata. The research methodology was derived essentially from the exhaustive Ayurvedic literature. Proper planning was done and no attempt was made to shift from the principles laid in the text while conduction the study. This dissertation comprises of four parts. Viz conceptual study, clinical study, discussion and summary & conclusion. 210 Summary The conceptual part deals with the understanding of the disease in terms of Ayurvedic as well as modern fundamentals. This part started with Amavata : an over view which presents the general survey of the disease. Historical aspect of Amavata is presented extending from vedic era to present era including modern historical review and the previous research work (regarding the thesis subject only) carried out by various Ayurvedic institution in India. It is followed by Etymology, Definition and classification of Amavata. Various concepts have been described under the heading of Basic concepts which includes – concept of Sandhi, Agni, Ama, Vata, Shleshma & Rasayana. The conceptual aspect of Nidana panchak (Nidana, Purvarupa, Rupa, Upashaya, Samprapti) Sapeksha nidana, Chikitsa, Pathyapathya, Sadhyasadhyata of Amavata are explained by taking into consideration of both Ayurvedic and modern point of view. The concept of selected therapy or yoga has also been presented under this heading. Conceptual aspects of drug properties are described with its action & effect on individual contents of Samprapti ghataka of Amavata, under the heading Drug review. This chapter also contains the Guna karma of the drug on various system of the body. The contraindication, purification, toxic effects of the drug also described under this heading. The second part entiled as clinical study which includes aims and objectives, Criteria of assessment, observation and results given by the drug; Shaman ((Rasonadi Kwatha, Shiva Guggul, Amrit manjari Ras) & Shodhan (Vaitaran Vasti)) in the management of Amavata. The results obtained are presented methodically according to group studied. For clinical trial the selected formulation was – Rasonadi Kwatha, Shiva Guggul, Amrit manjari Ras from Bhaisajya Ratnawali Aamvat rogadhikar by Govind Acharya Ji & Vaitaran Vasti from Chakradutt Aamvatroga Vastiadhikar by Chakrapanidutt Acharya ji. For the clinical study 80 patients presenting with clinical picture of Amavata were selected randomly from OPD and IPD of Govt. State Ayurvedic college and hospital, Lucknow. These patients were divided into 3 groups according to chronicity and severity of the disease. For Group A- For Internal administration Rasonadi Kwath 40 ml after meal twice daily, Shiva guggul1gm thrice daily with lukewarm water Amrit manjari ras250 mg thrice daily with lukewarm water for four months. 211 Summary Group B- For Internal administration Rasonadi Kwath 40 ml after meal twice daily, Shiva guggul1gm thrice daily with lukewarm water for four months & Vaitran Vasti was introduced in amount of app. 200ml for consecutive 9 days regularly. Group C- For Internal administration Rasonadi Kwath 40 ml after meal twice daily, Shiva guggul1gm thrice daily with lukewarm water Amrit manjari ras250 mg thrice daily with lukewarm water for four months & Vaitran Vasti was introduced in amount of app. 200ml for consecutive 9 days regularly This trial group was compained with another group. The total duration of treatment in both group was 4months. Through the entire therapy the patients were advice to follow-up the pathyahara and vihara of Amavata mentioned in classics. Prior to the treatment, a detailed proforma was duly filled for each patient and necessary laboratory investigations were carried out to assess the disease activity as well as general condition of the patient after the treatment. In case of IPD patients daily follow-up was done and in OPD patients assessment was done in every 15 days. Laboratory investigations were repeated after completion of therapy. A keen observation was made and composed in various table forms & graphs under the heading observation. Effects of the therapies on sign & symptoms, functional parameters, laboratory investigation etc. was adjudged and critically analised. The results thus obtained finally were subjected for statistical analysis for a good comparison of the therapies. The end results thus obtained were interpreted and graded as complete remission, major improvement, minor improvement and unimproved. The third part of the dissertation comprises the critical analysis of owed result based on Ayurvedic & modern fundamentals is presented under the heading Discussion. It can be concluded that Rasonadi Kwath, Shiva guggul & Amrit manjari ras with Vaitrana Vasti provide better result in the management of Amavata . Fourth part of the study includes the summary and conclusion of the whole work done in a brief manner. 212