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 SYLLABUS 11/2 M 11/4 W 11/6 F 11/9 M 11/11 W 11/13 F 11/16 M 11/18 W 11/20 F 11/23 M 11/25 W 11/30 M 12/2 W 12/4 F 12/7 M MICRO 224 INTRODUCTION TO MICROBIAL PATHOGENESIS HOST-­‐PATHOGEN INTERACTION Establishment of Review major host defense mechanisms; How microbes interact Infection with host and manifest disease: general concepts of colonization; invasion; and how microorganisms manifest pathogenesis (toxigenesis, interaction host machinery); concept of acute/chronic Biology of Bacteria Basic characteristics: grouping of bacteria; medically important bacteria. Concepts of relationship of bacterial structures to pathogenesis GRADUATE RESEARCH Take home assignment: Falkow’s Molecular Koch’s Postulates DAY Biology of Pathogenic General characteristics of eukaryotic pathogens:fungi and Eukaryotes parasites; focus on medically important pathogenic eukaryotes; identification of areas with medical implications Biology of Viruses General characteristics of virus structure and replication; medically important viruses Bacterial Pathogenesis Major pathogenesis mechanisms: Virulence Factors; Toxins and Secretion Systems; concept of persistence Viral Pathogenesis Acute, chronic and latent viral infections; mechanisms of pathogenesis and transmission Eukaryote Major pathogenesis mechanisms: Virulence ‘attributes’; Pathogenesis antigenic variation; Concept of chronic vs acute infections and relationship between specific fungi/parasites Evaluation In class short answer exam COMMON THEMES OF INFECTIOUS DISEASE Long term residency in Concept of latency and persistency expanded upon; focus on host specific examples Immune evasion Shared mechanisms of pathogen evasion of host immunity; usurping host signaling pathways and processes Antigen switching Concept of antigen switching; differences in outcome dependent on antigen/ organism Exploitation of How organisms survive in the host by exploiting different metabolic resources resources; specific examples, eg. glucose, iron, etc Methods to disrupt Introduction to antimicrobial strategies which target common pathogen pathways/processes in host and/or pathogen in order to alleviate infection, ie. immunotherapy, nucleosides, statins Evaluation In class essay exam Sturtevant Shen/McGowin Sturtevant/Kelly Amedee Shen/ McGowin Amedee/ Foster Sturtevant/Kelly Staff Aiyar Sturtevant/Ramsay Kelly Aiyar Foster