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27 - Photonic Materials, Devices and Systems â Laser Medicine and Medical Imaging Group â 27 RLE Progress Report 144 Figure 10. OCM en face images taken of Xenopus laevis tadpole and of a laser-fabricated waveguide embedded in glass (c). Images a, d-e are 1375x250 pixels taken at 4 frames per second, while images b and c are 1375x500 pixels taken at 2 frames per second. The field of view in the images is 130 µm x 140 µm. We will combine our work on broad-bandwidth light sources with our new system design to achieve high-resolution OCM at multiple wavelengths. We believe the system will provide a powerful tool for optical biopsy to explore the limits of coherence-gated imaging for clinical diagnostic purposes. Ultrahigh Resolution Ophthalmic Imaging Sponsors National Institute of Health Grant NIH-2-R01 EY11289-15 National Institute of Health Grant NIH-1-R01-EY131780-01 National Institute of Health Grant NIH-5-R01-CA75289-04 Air Force Office of Scientific Research (MFEL) Grant F49620-01-1-0186 Air Force Office of Scientific Research Grant F49620-98-01-0084 Project Staff Aaron Aguirre, Ravi Ghanta, Tony Ko, Andrew M. Kowalevicz, Pei-Lin Hsuing, Paul Herz, Dr. Stephane Bourquin, Dr. Christian Chudoba, Dr. Wolfgang Drexler, Dr. Ingmar Hartl, Dr. Hiroshi Ishikawa, Dr. Adelina Paunescu, Dr. Thomas Schibli, Dr. Ping Xue, Nirlep Patel, Karl Schneider, Dr. Uwe Morgner, Professor Franz X. Kartner, Professor Mark Brezinski, Professor Joel Schuman (New England Eye Center), and Professor James G. Fujimoto OCT has perhaps been most widely investigated in ophthalmology, where it is beginning to make a clinical impact in the assessment of retinal diseases such as macular holes, age-related macular degeneration, glaucoma, and diabetic retinopathy [1, 21-23]. Current clinical practice 27-12
