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Transcript
Serotonin Biosynthesis Model Guide Neurotransmitters Module: The Beery Twins’ Story© A Project-Based Learning Activity TPH Tryptophan 5-Hydroxtryptophan Tryptophan (Trp or W) is one of the 20 standard amino acids and is an essential amino acid that cannot be synthesized by the human body. Tryptophan is composed of the standard amino acid backbone with an indole ring side chain. Version 1.4 -11/2015 http://cbm.msoe.edu AAAD 5-Hydroxytryptophan, an intermediate molecule in the serotonin biosynthesis pathway, is formed by the addition of a hydroxyl (OH) group to the fifth carbon of the indole ring of tryptophan. Neurotransmitter (Serotonin) TPH Tryptophan Hydroxylase AAAD Aromatic L-Amino Acid Decarboxylase (requires tetrahydrobiopterin as a cofactor) (requires vitamin B6 as a cofactor) Serotonin The final step in the serotonin biosynthesis pathway requires the removal of the carboxylic acid group (COOH) from the backbone of 5-hydroxytryptophan to form the neurotransmitter serotonin. Model Color Key Oxygen Carbon Hydrogen* Nitrogen * Hydrogens not shown in chemical drawings ...where molecules become real TM www.3dmoleculardesigns.com