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IMPLEMENTATION José A. Bengoechea Kick-off meeting Palma Mallorca January 24th 2013 INBIONET TIMELINE Submission………………11/01/2012 [15:14:49] Invitation to negotiation……7/05/2012 21/05/2012 (first draft Annex I) Annex I accepted by REA………18/7/2012 GA signature by REA…......11/09/2012 Project officer Mattia Zilli 1st of January 2013 Research Training INBIONET partners will combine their experience and expertise to deliver a state-of-the-art Research Programme in the competitive field of “microbial antiimmunology” with the goal of identifying novel therapies based on modulating the host-pathogen interaction. On the whole, it is expected that this training programme will provide the recruited scientists with the scientific and complementary skills they will need for a successful career in the field of “microbial anti-immunology” either in academia or industry. WP1 Innate responses WP5 Management WP2 Pathogen replication WP3 Training TU1: Immune signaling TU2: Animal models TU3: Mucosal immunology TU4: Entrepreneurship TU5: Complementary skills Academia Industry WP4 Science and society WP1 INNATE RESPONSES Lead: TCD Tasks are projects ESR1-ESR7; ER1-ER2 Annual report submitted to Supervisory Board Milestones M1: Implementation of cellular models to analyze the activation of PRRs M2: Implementation cellular models to analyze the activation of IFN Deliverables D1: Identification PRRs and PAMPs responsible for defense responses; D2: Viral and bacterial means to subvert type I IFN production, D3: Identification pathways suitable for immunomodulation WP2 PATHOGEN REPLICATION Lead: MFPL Tasks are projects ESR8-ESR11; ER3-ER4 Annual report submitted to Supervisory Board Milestones M1: Implementation in vivo models to measure mucosal immunity M2: Implementation in vivo models to manipulate mucosal immunity Deliverables D1: Bacterial intracellular survival strategies; D2: IFN control ofviruses and bacteria replication, D3: In vivo strategies for immunomodulation WP3 TRAINING Lead: EPFL Training Committee Tasks Embedding an ESR/ER into a research group. Preparation of Personal Development Plan. Establishment of INBIONET ESR/ER committees. Monitoring and reviewing of the work plan and timelines (12 months). Organization of TUs, including network workshops. Organization of rotations between laboratories. Organization of training sections of the network meetings. Annual report submitted to Supervisory Board WP3 TRAINING Lead: EPFL Milestones M1: Affiliation Graduate Schools M2: Personal Development Plan M3: INBIONET ESR/ER committees M4: Training units and network workshops* M5: Rotations* Deliverables D1: ESR/ER personal career plans*; D2: Research fellows progress reports*, D3: Training units and network workshops* WP3 TRAINING Lead: EPFL Local level Graduate Schools Local courses/seminars Language courses Network level INBIONET web page International meetings Training units (TUs) Network workshops (NWs) Network meetings (NMs) Secondments Final INBIONET conference WP3 TRAINING Lead: EPFL TU1 Experimental techniques of manipulation of innate immune signaling by pathogens at the cellular level. TCD M7 Dublin TU2 Animal models in inflammation, animal care and animal imaging. MPFL M9 Vienna TU3 Identification and functional characterization of innate immune cells in mucosal tissues. EPFL M18 Lausanne TU4 Know-how transfer and entrepreneurship. ParcBit M27 Palma Mallorca TU5 Complementary skills ParcBit * * WP3 TRAINING Lead: EPFL TU1 Experimental techniques of manipulation of innate immune signaling by pathogens at the cellular level. TCD, collaboration FISIB Dublin (M7) On-hands course on pathogen manipulation of innate immune signaling cascades at the cellular levels Offered ONLY to INBIONET fellows plus partners´ fellows (places available) WP3 TRAINING Lead: EPFL NW 1 Advanced topics in innate immune signaling TCD, collaboration FISIB Dublin (M7) 2 days lectures (keynote speakers), posters and oral presentations Offered to INBIONET fellows plus institutions´ fellows (places available) Gender issues: female speakers (magical figure of 40%) Outreach sesion: “The host-pathogen arms race: stories from the front line” WP3 TRAINING Lead: EPFL TU2 Animal models in inflammation, animal care and animal imaging. MPFL, Vienna (M9) Competence on animal techniques and experimental models useful for inflammatory and infectious diseases (including ethical issues). Offered ONLY to INBIONET fellows plus partners´ fellows (places available) WP3 TRAINING Lead: EPFL NW 2 Animal models in inflammation and infection MPFL Vienna (M9) 2 days lectures (keynote speakers), posters and oral presentations Offered to INBIONET fellows plus institutions´ fellows (places available) Gender issues: female speakers (magical figure of 40%) Outreach sesion: ‘How infectious diseases change human life’. WP3 TRAINING Lead: EPFL TU3 Identification and functional characterization of innate immune cells in mucosal tissues. EPFL, collaboration Preclin Lausanne (M18) On-hands course on analysis of mucosal innate immune responses. Offered ONLY to INBIONET fellows plus partners´ fellows (places available) WP3 TRAINING Lead: EPFL NW 3 Mucosal immunology EPFL, collaboration Preclin Lausanne (M7) 2 days lectures (keynote speakers), posters and oral presentations Offered to INBIONET fellows plus institutions´ fellows (places available) Gender aspects: female speakers (magical figure of 40%) Outreach sesion: Mice, amoebas, flies and worms helping research’. WP3 TRAINING Lead: EPFL TU4-NW4Know-how transfer and entrepreneurship. ParcBit, collaboration FISIB Palma Mallorca (M27) Process of company creation in the European biotechnology sector. Offered ONLY to INBIONET fellows plus partners´ fellows (places available) Gender aspects: female speakers (magical figure of 40%) Outreach sesion: “Translational medicine: from the lab to the company to the bed”. WP3 TRAINING Lead: EPFL TU5 Complementary skills ParcBit, collaboration FISIB Linked to the Network meetings Offered ONLY to INBIONET fellows plus partners´ fellows (places available) scientific communication skills; NM1-3 how to write scientific applications; NM3 career planning and job hunting; NM2-3 laboratory/group management. NM3 Keynote speaker ??? WP3 TRAINING Lead: EPFL Secondments At least 2 per fellow Academia and industry and vicerversa At least 2 months, “fixed period” 1. IP (2 months, within M18-M24) to assess the modulation of ubiquitination by Klebsiella spp. 2. Sanofi (4 months, within M26-M36) In vivo pneumonia model tagging bacteria and host molecules. WP4 SCIENCE and SOCIETY Lead: USTAN Tasks: Advertising of INBIONET activities Preparation and dissemination of INBIONET E-Newsletter. INBIONET video clips. Maintenance of INBIONET web page as open access resource of data. Dissemination via social media (Twitter and Blog). Establishment and maintenance of links with national Microbiology/Immunology Societies and local Graduate schools. Establishment and maintenance of contacts with European research initiatives. (INFECT-ERA) Outreach activities. Development of an agenda for long lasting collaborations between academic research groups and industry. WP4 SCIENCE and SOCIETY Lead: USTAN Deliverables D1: Social media accounts (Twitter, Blog)*; D2: E-Newsletter *, D3: INBIONET Video-clips * WP4 SCIENCE and SOCIETY Lead: USTAN Outreach activities: Twitter (@INBIONET) INBIONET Blog (each fellow 2 post per yr) Outreach reports (each fellow 2 per yr) E-Newsletter (every 6 months) INBIONET clips (each fellow 2) Outreach sessions workshops WP5 MANAGEMENT Lead: FISIB Tasks: Organization of the kick-off meeting Development of the INBIONET web site Recruitment Organization of the Network meetings (agenda, speakers,…) Monitoring and evaluation of the WPs´ progress reports. Organization of the mandatory Mid-term review. WP5 MANAGEMENT Lead: FISIB Supervisory Board Training Committee Recruitment Committee Patenting Committee Network Management Supervisory Board S trategic decision-making body Formed by all partners and chaired by coordinator Meeting once per yr during Network meetings Consensus-voting rules (2/3 quorum; simple majority) WP5 MANAGEMENT Lead: FISIB Supervisory Board Training Committee Recruitment Committee Patenting Committee Network Management Training committee Responsible training programme, gender issues TCD, MPFL, EPFL, ParcBit, FISIB, Preclin, Sanofi, one ESR (female) Meeting once per yr during Network meetings Consensus-voting rules (2/3 quorum; simple majority) WP5 MANAGEMENT Lead: FISIB Supervisory Board Training Committee Recruitment Committee Patenting Committee Network Management Recruitment committee Responsible recruitment, employment, gender issues TCD, FISIB, EPFL, IP, Preclin Meeting once per yr during Network meetings Consensus-voting rules (2/3 quorum; simple majority) WP5 MANAGEMENT Lead: FISIB Supervisory Board Training Committee Recruitment Committee Patenting Committee Network Management Patenting committee Responsible exploitation issues, protection of intellectual property FISIB, Preclin, Sanofi, ParcBit, IP According to Consortium Agreement Meeting once per yr during Network meetings Consensus-voting rules (2/3 quorum; simple majority) WP5 MANAGEMENT Lead: FISIB Coordinator Project manager Partners Fellows Work package leaders Committee chairs Supervisory Board Work package leaders submit annual progress report WP5 MANAGEMENT Lead: FISIB Management meetings Kick-off meeting: Palma de Mallorca, hosted by FISIB (M1) 1st Network meeting: Vienna (Austria), hosted by MFPL (M12) 2nd Network meeting: Paris, hosted by IP (M21; mid-term review) 3rd Network meeting: Berlin, hosted by MPIIB (M30) 4th Final conference: Palma de Mallorca, hosted by FISIB and ParcBit (M41) RECRUITMENT Early Stage Researchers (ESR) No PhD Research experience ≤ 4* years 36 months Experienced Researchers (ER) still in their early career PhD or Research experience ≥ 4* years AND Research experience ≤ 5* years 24 months * counted from the diploma that gives the rights to embark in a doctoral degree RECRUITMENT RECRUITMENT 40% female researchers RECRUITMENT RECRUITMENT RECRUITMENT RECRUITMENT ….Teleconference coordinator… Personal career development plan Declaration of conformity INBIONET ESR committee Supervisor+colaborator+other ESR selected (non collaborator) INBIONET ER committee Supervisor+other ER selected …Reports for Commission… …Reports for INBIONET… Annual progress report evaluated by INBIONET ESR/ER committee Oral presentation evaluated by INBIONET ESR/ER committee GENDER ASPECTS 40% of fellows Keynote speakers (aiming 40%) ESR appoint to Training committee will be female Monitoring actions Recruitment committee for working related Training committee for training related Training Fellows' Recruitment month s 1 ESR1 ESR2 ESR3 ESR4 ESR5 ESR6 ESR7 ER1 ER2 ESR8 ESR9 ESR10 ESR11 ER3 ER4 TUs Worksh op second ments On line support 6 1 2 1 2 1 2 1 8 5 3 2 4 5 3 3 0 4 3 6 4 2 5 5 B P M 4 8 4 Management Dissemin Outreach Meetin gs Social media Newslet er Clips Blog posts Session Reports K V P E PROJECT MONITORING Periodic and final reports are contractual deliverables Research activities Training activites Management activities Dissemination activities IMMEDIATE ACTIONS Committees Recruitment call Consortium Agreement Animal permissions Budget transfer …going for dinner…