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Novel Technologies to assess Gut
Health Claims for Carbohydrates
Subthema 1: Synthesis and structural analysis
of functional oligosaccharides
Name:
Prof. Dr. Lubbert Dijkhuizen
Affiliation: University of Groningen/ Microbiology
Contact:
[email protected]
Synthesis and structural analysis of
functional oligosaccharides
State of the art:
Availability Characterized
Fructo-, Galacto-, (Iso)Malto+
+?
Xylose-, Pectin-, Mannan-, Chito-
(+)
(+)??
Glucose1,2-1,3-1,4; IMO-MALT
(+)
-
Glucansucrase acceptor products
(+)
-
Plant cell wall oligo’s
(+)
-
Human Milk oligo’s
(+)
-
“CCC new oligo’s”
-
-
Synthesis and structural analysis of
functional oligosaccharides
New technologies:
Enzyme discovery and engineering:
synthesis of tailor-made oligo’s:
monosaccharides, linkages
Structural analysis:
In vitro: newly synthesized oligo’s
In gut: modification, degradation, during passage