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Lecture 24 Web: pollev.com/ucibio Text: To: 37607 Type in: 169964 <your question> Regulation Regulation Carbons for amino acids Amino acids = More than proteins! Creatine Glutathione Heme Nitric oxide Hormones Neurotransmitters Nucleotide synthesis from many molecules Synthesis of purines… …starts on a ribose molecule A & G from I Regulation of purine synthesis Pyrimidine biosynthesis Regulation Regulation In the presence of CTP, enzyme changes: A. No change in kinetic parameters B. Vmax increases C. Km increases D. Vmax decreases, Km increases E. Vmax decreases, Km increases, kcat increases Nucleotide metabolism… Still have a MAJOR question… A. Source of C and N for Pu and Py rings B. Regulation of synthesis C. NTP dNTP D. NMP NTP E. Difference between plants & animals Oxy deOxy Regulation by reduction! Regulation of ribonucleotide reductase The deal with THF