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The Visceral Nervous System SHANDONG UNIVERSITY Liu Zhiyu The Visceral Nervous System Composition Visceral motor nerves (autonomic nervous system) Sympathetic part Parasympathetic part Visceral sensory nerves Somatic and Autonomic Nervous System Main Differences Between Somatic Motor and Visceral Motor n. Somatic Visceral Effectors Skeletal muscles Cardiac, smooth muscles and glands Control Voluntary (consciousness) Involuntary (unconsciousness ) From lower center to effect require Single neuron Two neurons: preganglionic neuron and postganglionic neuron Kind of fibers One Two: sympathetic & parasympathetic Fibers Thick myelinated Preganglionic: thin myelinated postganglionic: unmyelinated Distributive form Nerve trunk Nerve plexuses Somatic and Autonomic Nervous System Somatic and Autonomic Nervous System Somatic Skeletal muscle Conscious and unconscious movement Skeletal muscle contracts One synapse Acetylcholine Autonomic Smooth and cardiac muscle and glands Unconscious regulation Target tissues stimulated or inhibited Two synapses Acetylcholine by preganglionic neurons and ACh or norepinephrine by postganglionic neurons Neurotransmitters SOMATIC NERVOUS SYSTEM AUTONOMIC NERVOUS SYSTEM Sympathetic ACh ACh ACh Parasympathetic Ad. M. ACh ACh Striated muscle NE Heart Sm. mus. Glands ACh Sweat glands ACh Heart Sm. mus. Glands E, NE Sympathetic Part Lower center: located in intermediolateral nucleus (lateral gray horn) of spinal cord segments T1~L3 Sympathetic ganglia Paravertebral ganglia Prevertebral ganglia Paravertebral Ganglia Arranged on either side of vertebral column Consist of 19~22 of ovalshaped ganglia 3 cervical 10~12 thoracic 4 lumbar 2~3 sacral Ganglion impar : unpaired on the anterior face of coccyx Paravertebral Ganglia Superior cervical ganglion: largest, situated in front of transverse processes of C1~C3 vertebra Middle cervical ganglion: smallest, is at level of transverse processes of C6 vertebra Inferior cervical ganglion: situated at level of C7 vertebra, and may be fused with first thoracic ganglion to form cervicothoracic ganglion Paravertebral Ganglia Sympathetic Trunk Formed by paravertebral ganglia and interganglionic branches Lie on either side of vertebral column from base of skull to coccyx The trunks of two side unite in front of the coccyx at a small swelling, the ganglion impar Prevertebral Ganglia Lie anterior to vertebral column and near the arteries for which they are named Celiac ganglion Aorticorenal ganglion Superior mesenteric ganglion Inferior mesenteric ganglion Preganglionic Fibers Preganglionic fibers 15 pairs white communicating branches (only spinal levels T1~L3 have white communicating branch) Sympathetic trunk Three Fates of Preganglionic Fibers 1. Relay in corresponding ganglion 2. Ascend or descend in sympathetic trunk and relay in higher or lower ganglia 3. Pass without synapse to a prevertebral ganglion for relay Preganglionic Fibers Greater splanchnic nerve formed by preganglionic fibers from T5~T9 ganglia, and relay in celiac ganglion. Lesser splanchnic nerve formed by preganglionic fibers from T10~T12 ganglia, and relay in aorticorenal ganglion. The postganglionic fibers supply the liver, spleen, kidney and alimentary tract as far as the left colic flexure. Preganglionic Fibers Lumbar splanchnic nerve Formed by preganglionic fibers from L1~L4 ganglia, and relay in prevertebral ganglia. The postganglionic fibers supply descending and sigmoid colon, rectum, pelvic viscera and lower limbs. Three Fates of Postganglionic Fibers Back to a spinal nerve along gray communicating branches to terminate in blood vessels, arrector pili muscles and sweat glands of head, neck, trunk and limbs The fibers form their networks around blood vessels passing to visceral end organs Terminate directly in certain organs Postganglionic Fibers Distribution of Sympathetic Nerve Preganglionic fibers Postganglionic fibers T1~T5 Head, neck, upper limb and thoracic viscera T5~T12 Abdominal viscera L1~L3 Pelvic viscera and lower limb Parasympathetic Part Lower center: located in four pairs parasympathetic nuclei in brain stem and in sacral parasympathetic nucleus of spinal cord segments S2~S4 Parasympathetic ganglia: terminal ganglia are near or within the wall of a visceral organ Para-organ ganglia Ciliary ganglion Pterygopalatine ganglion Submandibular ganglion Otic ganglion Intra-organ ganglia Cranial Portion of Parasympathetic Nerve Ⅲ sphincter pupillae and ciliary muscles ciliary ganglion Ⅶ lacrimal gland pterygopalatine ganglion Ⅸ submandibular ganglion sublingual gland submandibular gland parotid gland Ⅹ otic ganglion terminal ganglia heart, lungs, liver, spleen kidneys,alimentary tract as far as left colic flexure Cranial Portion of Parasympathetic Nerve Ⅲ accessory oculomotor nucleus 〈○ sphincter pupillae and ciliary muscles ciliary ganglion Ⅶ pterygopalatine ganglion 〈○ lacrimal gland superior salivatory nucleus 〈○ submandibular ganglion sublingual gland submandibular gland Ⅸ 〈○ otic ganglion inferior salivator nucleus Ⅹ dorsal nucleus of vagus n. 〈○ terminal ganglia parotid gland heart, lungs, liver, spleen, kidneys,alimentary tract as far as left colic flexure Sacral Portion of Parasympathetic Nerve Preganglionic fibers from sacral parasympathetic nucleus leave spinal cord with anterior roots of the spinal nerves S2~S4, Then leave sacral nerves and form pelvic splanchnic nerve and travel by way of pelvic plexus to terminal ganglia in pelvic cavity Postganglionic fibers terminate in descending and sigmoid colon, rectum and pelvic viscera Main Differences Between Sympathetic and Parasympathetic Sympathetic Parasympathetic Lower center Intermediolateral nucleus (lateral gray horn) of spinal cord segments T1~L3 Four pairs parasympathetic nuclei and sacral parasympathetic nucleus Ganglia Paravertebral, prevertebral Terminal Preganglionic f. Shorter Longer Postganglionic f. Longer Shorter Pre: Postganglionic 1: many more 1: a few Distributions Throughout the body Limited primarily to head and viscera of thorax, abdomen, and pelvis Different action Prepares for emergency situation (expends energy) Conserve and restore body energy (conserves energy) Main Differences Between Sympathetic and Parasympathetic Sympathetic Parasympathetic Different action Prepares for emergency situation (fight or flight) Conserve and restore body energy (rest and relaxation) Pupil Dilates Constricts Heart Increases force of contraction Decreases force of contraction Rhythm of the heart To become more rapid To make slow Blood pressure Heighten Depress Bronchi Dilates bronchi Constricts bronchi Main Differences Between Sympathetic and Parasympathetic FUNCTION OF THE IRIS Low light:iris dilates Sympathetic neurone Dilator pupillae Normal light Bright light:iris constricts Sphincter pupillae Pupil Parasympathetic neurone Ganglion Visceral Plexuses Cardiac plexuses Superficial , below aortic arch Deep, anterior to bifurcation of trachea Pulmonary plexus Visceral Plexuses Celiac plexus Abdominal aortic plexus Hypogastric plexus Superior hypogastric plexus Inferior hypogastric plexus (pelvic plexus) Visceral Sensory Nerves Nucleus of solitary tract Ⅶ,Ⅸ, Ⅹ Thalamus Enteroceptors Posterior horn Cerebral cortex Hypothalamus Effectors Sympathetic nerve Pelvic splanchnic nerve Somatic motor neurons visceral motor neuclei Referred Pain Pain originating from organs perceived as coming from skin Site of pain may be distant from organ Referred Pain Convergence theory: This type of referred pain occurs because both visceral and somatic afferents often converge on the same interneurons in the pain pathways. Excitation of the somatic afferent fibers is the more usual source of afferent discharge, so we “refer” the location of visceral receptor activation to the somatic source even though in the case of visceral pain. The perception is incorrect. The convergence of nociceptor input from the viscera and the skin. Referred Pain