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Complications of Suppurative Otitis Media Dr. Vishal Sharma Definition Infection spreads beyond muco-periosteal lining of middle ear cleft to involve bone & neighboring structures like facial nerve, inner ear, dural venous sinuses, meninges, brain tissue & extra-temporal soft tissue. Features of Complications • Severe otalgia, painful swelling around ear • Vertigo, nausea, vomiting • Headache + blurred vision + projectile vomiting • Fever + neck rigidity + irritability / drowsiness • Facial asymmetry • Otorrhoea + Retro-orbital pain + diplopia • Ataxia Classification • Intra-cranial • Extra-cranial, Intra-temporal • Extra-cranial, Extra-temporal • Systemic: septicemia, otogenic tetanus Classification Intra-cranial Complications 1. Extra-dural abscess 2. Subdural abscess 3. Meningitis 4. Brain abscess 5. Lateral Sinus thrombophlebitis 6. Otitic hydrocephalus 7. Brain fungus (fungus cerebri) Intra-temporal Complications • Acute mastoiditis • Coalescent mastoiditis • Masked mastoiditis • Facial nerve palsy • Labyrinthitis • Labyrinthine fistula • Apex Petrositis (Gradenigo syndrome) Extra-temporal Complications 1. Post-auricular abscess 2. Bezold abscess 3. Citelli abscess 4. Luc abscess 5. Zygomatic abscess 6. Retro-mastoid abscess Factors Affecting Pathogen Factors Patient Factors High virulence bacteria Young age Antimicrobial resistance Poor immune status Chronic disease (DM, TB) Physician Factors Poor socio-economic status Non-availability Lack of health awareness Injudicious antibiotic use Error in recognizing dangerous symptoms & signs Routes of entry 1. Bony erosion (cholesteatoma destruction, osteitis) 2. Retrograde Thrombophlebitis 3. Anatomical pathway: oval window, round window, internal auditory canal, suture line, cochlear & vestibular aqueduct 4. Congenital bony defects: facial canal, tegmen plate 5. Acquired bony defects: fracture, neoplasm, stapedectomy 6. Peri-arteriolar space of Virchow-Robin: spread into brain Erosion of tegmen tympani Coalescent Mastoiditis or Surgical Mastoiditis Pathogenesis Aditus Blockage Failure of drainage Stasis of secretions Hyperemic decalcification Resorption of bony septa of air cells Coalescence of small air cells to form cavity Empyema of mastoid cavity Pathogenesis Clinical Features & Investigation • Otorrhoea > 2 weeks, otalgia & deafness • Mastoid reservoir sign: pus fills up on mopping • Sagging of postero-superior canal wall due to periosteitis of bony wall b/w antrum & posterior E.A.C. • Ironed out appearance of skin over mastoid due to thickened periosteum • Mastoid tenderness present • Mastoid cavity in X-ray & CT scan Mastoid reservoir sign Sagging of posterior wall Ironed out appearance Mastoid cavity Mastoid cavity Mastoiditis Furunculosis H/o otitis media + - Deafness + - Position of pinna Down + outward + forward Forward Post-aural groove Deepened Obliterated Ear discharge Muco-purulent Serous / purulent Sagging of EAC wall + - TM congestion + - Tenderness Mastoid Tragal Post-aural lymph node - + X-ray Mastoid Coalescence of cells + cavity Normal Treatment • Urgent hospital admission • Broad spectrum I.V. antibiotics No response to medical treatment in 48 hrs Development of new complication Presence of sub-periosteal abscess – Myringotomy to drain out painful pus – Incision drainage of sub-periosteal abscess – Cortical Mastoidectomy Sub-periosteal abscess & fistula Pathology Production of pus under tension hyperaemic decalcification (halisteresis) + osteoclastic resorption of bone sub-periosteal abscess penetration of periosteum + skin fistula formation Sub-periosteal abscess formation Sub-periosteal fistula: dry Sub-periosteal fistula: wet Types of sub-periosteal abscess • Post-auricular • Bezold • Citelli • Zygomatic • Luc • Retro-mastoid • Parapharyngeal & Retropharyngeal Types of sub-periosteal abscess Post-auricular abscess Commonest. Present behind the ear. Pinna pushed forward & downward. Bezold & Citelli abscesses Bezold: neck swelling over sternocleido- mastoid muscle Citelli: neck swelling over posterior belly of digastric muscle D/D of Bezold’s abscess 1. Suppurative lymphadenopathy of upper deep cervical lymph node 2. Para-pharyngeal abscess 3. Parotid tail abscess 4. Infected branchial cyst 5. Internal jugular vein thrombosis Luc: swelling in external auditory canal Zygomatic: swelling antero-superior to pinna + upper eyelid oedema Retro-mastoid: swelling over occipital bone (? Citelli’s abscess) Parapharyngeal & Retropharyngeal: due to spread of pus along Eustachian tube Retromastoid abscess Incision drainage of abscess Gradenigo syndrome Persistent otorrhoea: despite adequate cortical mastoidectomy Retro-orbital pain: Trigeminal nv involvement Diplopia: convergent squint due to lateral rectus palsy by injury to abducent nv in Dorello’s canal under Gruber’s petro-sphenoid ligament, at petrous apex Persistent otorrhoea + Retro-orbital pain + Convergent squint Right Convergent squint Right gaze Central gaze Left gaze Etiology: Coalescent mastoiditis involving petrous apex along postero-superior & anteroinferior tracts in relation to bony labyrinth Diagnosis: 1. C.T. scan temporal bone for bony details. 2. M.R.I. to differ b/w bone marrow & pus Treatment: Modified radical mastoidectomy & clearance of petrous apex cells C.T. scan & M.R.I. Hearing preserving approaches to petrous apex • Eagleton’s middle cranial fossa approach • Frenckner’s subarcuate approach • Thornwaldt’s retro-labyrinthine approach • Dearmin & Farrior’s infra-labyrinthine approach • Farrior’s hypotympanic sub-cochlear approach • Lempert Ramadier’s peri-tubal approach • Kopetsky Almoor’s peri-tubal approach Hearing sacrificing approaches to petrous apex • Trans-cochlear approach • Trans-labyrinthine approach Spread of pus Labyrinthitis Introduction Inflammation of endosteal layer of bony labyrinth Route of infection: Round window membrane Pre-formed opening (Stapedectomy) Retrograde spread of meningitis via IAC / aqueducts Clinical forms: 1. Circumscribed (labyrinthine fistula) 2. Diffuse serous 3. Diffuse suppurative • Circumscribed: Fistula commonly involves lateral SCC. Presents with transient vertigo & positive fistula test I/L nystagmus with +ve pressure; C/L nystagmus with -ve pressure • Serous: Reversible, non-purulent, mild vertigo, I/L nystagmus, mild sensori-neural hearing loss • Purulent: Irreversible, purulent, severe vertigo, C/L nystagmus, severe / profound hearing loss Treatment: Bed rest (affected ear up). Avoid head movement. Labyrinthine sedative: Prochlorperazine, Cinnarizine Broad spectrum I.V. antibiotics Modified Radical Mastoidectomy: removes infection Open labyrinthine fistula: cover with temporalis fascia Fistula covered with cholesteatoma matrix < 2 mm: remove matrix & cover with temporalis fascia > 2 mm / multiple / over promontory: leave it Rehabilitation by Cawthorne-Cooksey Exercises Lateral SSC Fistula Facial nerve paralysis • Within 1st wk: due to nerve sheath edema • After 2 wks: due to bone erosion • Lower motor neuron palsy • Common in tubercular otitis media Treatment: • Modified Radical Mastoidectomy • Facial nerve decompression seldom required Meningitis • High grade persistent fever with rigors • Severe headache & neck stiffness • Irritability drowsiness confusion coma • Neck rigidity positive • Kernig sign positive; Brudzinski sign positive • Papilloedema • Lumbar Puncture: cell count, protein, sugar • I.V. Ceftriaxone + Metronidazole + Gentamicin • Radical Mastoidectomy once patient is stable Test for neck rigidity Otogenic brain abscess Introduction 50-75 % adult brain abscess & 25% in child = otogenic Temporal abscess : Cerebellar abscess = 2:1 Route of infection: 1. Direct spread: via Tegmen plate: Temporal abscess via Trautmann’s triangle: Cerebellar abscess 2. Retrograde thrombophlebitis Trautmann’s triangle Superiorly: superior petrosal sinus Posteriorly: sigmoid sinus Anteriorly: solid angle (semi-circular canals) Pathway to posterior cranial fossa from mastoid cavity Stages of brain abscess 1. Invasion or Encephalitis (1-10 days) 2. Localization or Latent Abscess (10-14 days) 3. Expansion or Manifest Abscess (> 14 days): leads to raised intracranial tension & focal signs 4. Termination or Abscess rupture: leads to fatal meningitis Stages of brain abscess Clinical Features of ed I.C.T. Seen more in cerebellar abscess • Severe persistent headache, worse in morning • Projectile vomiting • Blurring of vision & Papilloedema • Lethargy drowsiness confusion coma • Bradycardia • Subnormal temperature Focal Clinical Features Temporal Lobe Cerebellum Nominal aphasia I/L nystagmus Quadrantic homonymous I/L weakness I/L hypotonia hemianopia (C/L) Epileptic seizures I/L ataxia Pupillary dilatation Intention tremor Hallucination (smell & taste) Past-pointing C/L hemiplegia Dysdiadochokinesia Bacteriology • Anaerobic streptococci • Streptococcus pneumoniae • Staphylococci • Proteus • E. coli • Pseudomonas • Bacteroidis fragilis Investigations CT scan of brain & temporal bone with contrast Site, size & staging of abscess Observe progression of brain abscess Associated intra-cranial complications MRI brain D/D: pus, abscess capsule, edema & normal brain Spread to ventricles & subarachnoid space Avoid lumbar puncture to prevent coning Temporal abscess in CT scan Cerebellar abscess Medical Treatment • High dose broad spectrum I.V. antibiotics: Ceftriaxone + Metronidazole + Gentamicin • I.V. Dexamethasone 4mg Q6H: es oedema • I.V. 20% Mannitol (0.5 gm/kg): es I.C.T. • Anti-epileptics: Phenytoin sodium • Antibiotic ear drops & aural toilet Surgical Treatment • Repeated burr hole aspirations • Excision of brain abscess with capsule: best Tx • Open incision & evacuation of pus • Radical mastoidectomy after pt becomes stable Lateral sinus thrombophlebitis Pathogenesis Lateral sinus = Sigmoid sinus + Transverse sinus Erosion of sigmoid sinus plate peri-sinus abscess inflammation of outer wall endophlebitis mural thrombus occlusion of sinus lumen intra-sinus abscess propagating infected thrombus Pathogenesis Spread of thrombus Proximal: 1. To superior sagittal sinus via torcula Hirophili hydrocephalus 2. To cavernous sinus proptosis 3. To mastoid emissary vein Griesinger’s sign Distal: To internal jugular vein & subclavian vein pulmonary thrombo-embolism & septicaemia Clinical Features • Remittent high fever with rigors (picket fence) • Pitting edema over retro-mastoid area & occipital bone due to mastoid emissary vein thrombosis (Griesinger’s sign) • Tenderness along Internal Jugular Vein • Headache • Anaemia Fever charts in C.S.O.M. Brain abscess Meningitis Lateral Sinus Thrombophlebitis Picket fence fever • High fever, swinging type • Chills precedes fever • Temperature subsides with sweating • Each fever spike due to release of fresh septic embolus Special Tests • Queckenstedt or Tobey-Ayer test: compression of I.J.V. rapid rise of C.S.F. pressure (50 – 100 mm water rapid fall on release of compression. In L.S.T. no rise / rise by only 10 – 20 mm water. • Lillie – Crowe - Beck test: pressure on I.J.V. on normal side engorgement of retinal veins + papilloedema seen in fundoscopy due to L.S.T. on opposite side. Tobey Ayer Test Retinal vein dilation & optic disc edema Investigations Lumbar puncture: to rule out meningitis CT brain with contrast: MRI brain with contrast: Delta sign or Empty triangle sign MR angiography Blood culture Culture & sensitivity of ear discharge Peripheral blood smear: to rule out malaria Delta sign Treatment 1. Radical mastoidectomy: Removal of disease + needle aspiration to confirm diagnosis. Sinus wall incised. Infected clots removed & abscess drained. 2. I.V. Ceftriaxone + Metronidazole + Gentamicin 3. Anticoagulants: in cavernous sinus thrombosis 4. Internal jugular vein ligation: for embolism not responding to antibiotics & surgery 5. Blood transfusion: for anaemia Extra-dural abscess Extra-dural abscess Commonest otogenic intra-cranial complication Collection of pus b/w skull bone & dura of middle or posterior cranial fossa Majority asymptomatic. Suspected in case of: Profuse, intermittent, pulsatile, purulent, otorrhoea Low grade fever I/L Persistent headache Recurring meningococcal meningitis CT scan brain shows extra-dural abscess Tx: I.V. Ceftriaxone + Metronidazole + Gentamicin Modified Radical mastoidectomy Drill tegmen or sinus plate pus drained Extra-dural abscess Subdural abscess Subdural abscess Collection of pus b/w dura & arachnoid by erosion of bone & dura mater or by retrograde thrombophlebitis Due to rapid spread of pus, symptoms of raised intracranial tension & meningeal irritation develop quickly CT scan brain shows subdural abscess Tx: I.V. Ceftriaxone + Metronidazole + Gentamicin Burr hole evacuation of pus Radical mastoidectomy after pt becomes stable Subdural abscess Otitic Hydrocephalus Synonym: Benign intra-cranial hypertension Symond’s syndrome Etiology: 1. Associated L.S.T. obstruction of cerebral venous return. 2. Superior sagittal sinus thrombosis ed C.S.F. absorption Clinical Features: 1. Severe headache, vomiting 2. Blurred vision, papilloedema, optic atrophy 3. Abducens palsy & diplopia due to raised intra-cranial tension (False localizing sign) Investigations: 1. Lumbar puncture: ed CSF pressure (> 300 mm H2O). Biochemistry & bacteriology normal 2. CT scan brain: normal ventricles Treatment: 1. Tx of L.S.T.: I.V. antibiotics & MRM 2. se CSF pressure (prevents optic atrophy) by: I.V. Dexamethasone 4mg Q6H I.V. 20% Mannitol 0.5 gm/kg Repeated lumbar puncture / lumbar drain Ventriculo-peritoneal shunt Brain Fungus • Prolapse of brain into middle ear cavity / mastoid cavity due to erosion of dural plate. • Common in pre-antibiotic era. Rarely seen now in resistant infections. • Diagnosis: C.T. scan temporal bone. • Treatment: Removal of necrotic tissue, replacement of healthy prolapsed brain into cranial cavity & repair of bone defect. Fungus Cerebri Thank You