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www.cis.rit.edu/seminar for schedule, abstracts, biographies, and video archives Imaging Human Brain Structure and Function through MRI Andrew Michael, PhD “With nearly 100 billion neurons and 100 trillion connections, the human brain remains one of the greatest mysteries in science and one of the greatest challenges in medicine. Neurological and psychiatric disorders, such as Alzheimer’s disease, Parkinson’s disease, autism, epilepsy, schizophrenia, depression, and traumatic brain injury, exact a tremendous toll on individuals, families, and society. Despite the many advances in neuroscience in recent years, the underlying causes of most of neurological and psychiatric conditions remain largely unknown, due to the vast complexity of the human brain. If we are ever to develop effective ways of helping people suffering from these devastating conditions, researchers will first need a more complete arsenal of tools and information for understanding how the brain functions both in health and disease”. – President Obama’s BRAIN initiative, 2013 Over the last decade or so Magnetic Resonance Imaging (MRI) has become the primary tool to in vivo image the human brain to construct theories about the underpinnings of its function and dysfunction. This seminar will begin with brief introductions to basics of MRI, structural MRI, functional MRI (fMRI) and diffusion tensor imaging and their image processing pipelines. We will then focus on fMRI and some of the recent findings: spatially distributed patterns of brain activation, resting state brain networks, the default mode network and ‘mind reading’. In addition functional brain networks obtained from fMRI data have helped us to better understand brain disorders. Mathematical tools used to extract functional brain networks will be discussed. We will conclude by discussing current limitations and future directions of brain imaging. 3PM, WEDNESDAY, FEBRUARY 18, 2015 Carlson Auditorium, Center for Imaging Science (CAR)