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Bio 449 Lecture 10 - Sensory Physiology II General mechanisms (cont’d) Receptive field size Lateral inhibition Chemoreception - taste and smell Gustation Olfaction Terms to Know Receptive field size Lateral inhibition Gustation Taste bud Taste receptor cell Umami Gustducin Tastant Olfaction Olfactory receptor cell Olfactory epithelium Olfactory bulb Odorant Readings Lectures 10 & 11: Chapter 10, pages 349-379 Lectures 12-14: Chapters 6 & 7 Sep. 17, 2010 Receptive Field Size (b) (a) Compass with points separated by 20 mm Skin surface Skin surface Primary sensory neurons Secondary sensory neurons One signal goes to the brain. Fig. 10-3 Two signals go to the brain. Gustation Sweet Umami Bitter Salty or sour Tight junction Support cell Taste pore Presynaptic cell ATP Serotonin Receptor cells Primary gustatory neurons Fig. 10-16 Taste Bud Taste Transduction 1 Gustducin Sweet, umami, or bitter ligand Salt Sour Na+ H+ 1 GPCR 2 1 Na+ 2 H+ 2 Signal transduction Cell depolarizes Ca2+ Ca2+ 3 3 ? ? Ca2+ Ca2+ 3 Ca2+ Ca2+ ? ATP Serotonin 4 4 4 Primary gustatory neurons Fig. 10-17 5 5 5 Receptor A Receptor B Receptor C Receptor D Olfaction Olfactory bulb Olfactory epithelium Fig. 10-14 Olfactory tract Brain Olfaction Olfactory bulb Glomeruli Mitral cells To limbic system and cerebral cortex Bone Cilia Olfactory receptors Olfactory Receptors Developing olfactory cell Olfactory receptor cell Supporting cell Olfactory cilia Mucus layer Fig. 10-14 Touch Receptors Merkel receptors Hair Meissner’s corpuscle Free nerve ending Hair root Sensory nerves Pacinian corpuscle Ruffini corpuscle Fig. 10-11