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STANDARD ERROR • Standard error is the standard deviation of the means of different samples of population. • Standard error of the mean • S.E. is a measure which enables to judge whether a mean of a given sample is within the set of confidence limits or not, in a population. • S.E= SD/√n SAMPLING • Not possible to include each & every member • Not possible to examine all people of country • To test efficacy of drug to all patients • Cooking of rice • Costly collection & Time consuming • Blood test POPULATION • Population • Sample • Parameter: a value calculated from a population – Mean (μ) – Standard Deviation(σ) • Sample – Mean (X) – Standard deviation ( s) SAMPLING • Sample is a part of population • Estimation of population parameters • To test the hypothesis about the population from which the sample was drawn. • Inferences are applied to the whole population but generalization are valid if sample size is sufficiently large & must be representative of the population-unbiased. SAMPLING • Sampling units are break down of population into smaller parts which are distinct and non overlapping so that each member / element of the population belongs to one and only one sampling unit. • When a list of all individuals , households, schools and industries are drawn, it is called sampling frame. Sample • A representative sample is the one with which we can draw valid inference regarding the population parameters. • It is representative of the population under study • Is large enough but not too large • The selected elements must be properly approached, included and interviewed. SAMPLING • Selected by proper sampling from the universe • Differs from the universe in composition solely by chance • Each member has the equal chance to be selected • Sample mean is very close to the population mean when bias has been ruled out. SAMPLING TECHNIQUES • • • • • • • • • SIMPLE RANDOM SAMPLING SYSTEMATIC SAMPLING STRATIFIED SAMPLING MULTISTAGE SAMPLING CLUSTER SAMPLING MULTIPHASE SAMPLING CONVENIENT SAMPLING QUOTA SAMPLING SNOW BALL SAMPLING SIMPLE RANDOM SAMPLING • Every unit has an equal chance to be included in the study • This is done by assigning a no. to each unit in the sampling frame. • It is a haphazard collection of no. arranged in a cunning manner to eliminate personal selection or bias. SYSTEMATIC RANDOM SAMPLING • Sample is selected according to a predetermined periodicity out of the total no. in the series • Systematic R Sampling selects every Kth element in the population for the sample, with the starting point determined randomly from the first k elements. • Easy to obtain, simple to design • Time and labour are relatively small • When population is large---results accurate result. • Sample values spread to entire population STRATIFIED RANDOM SAMPLING • It simply selects simple random samples from mutually exclusive subpopulations or strata of the population. • Population is first divided into groups or strata then sample is drawn according to size of the strata---proportional allocation • Reduced variability within the stratum yields more precise estimate of the population. • Stratification of a population results in strata of various sizes MULTISTAGE SAMPLING • It refers to the sampling procedures carried out in different stages using simple random sampling technique. • It introduces flexibility in sampling • It enables use of exiting divisions & sub divisions which saves extra labour. CLUSTER SAMPLING • A cluster is a selected group • When units of population are natural groups or clusters e.g. villages, wards, factories • It allows small no. of target population to be sampled. • From the cluster chosen, the entire population is surveyed. • E.g. vaccination coverage • Cost effective when population is scattered. MULTIPHASE SAMPLING • Part of the information is collected from the whole sample and part from the subsample Non probability sampling • Convenient sampling – The probability that a subject is selected is unknown – It reflects selection bias of a person • Quote sampling TARGET POPULATION • Is the population to which the investigator wishes to generalize • SAMPLE POPULATION • Is the population from which the sample was actually drawn CONFIDENCE INTERVAL • It is the interval or range of values which most likely encompasses the true population value. • It is the extent that a particular sample value deviates from the population • A range or an interval around the sample value • Range or interval is called confidence interval. • Upper & lower limits are called confidence limits. C.I • Random sample of 11 three years children were taken, sample mean was 16 Kg and standard deviation is 2 Kg. standard error is 0.6 Kg. find C.I. TESTING THE STATISTICAL HYPOTHESIS • Null hypothesis or hypothesis of no difference (Ho) • Alternative hypothesis of significant difference (H)׀ • Test of significance to accept or reject hypothesis • A zone of acceptance • A zone of rejection Testing of hypothesis • Z- test when sample is more than 30 • T-test when sample is less than 30 • Chi square test when the data is in proportions Sample size • L= 2 σ √n √n= 2 σ L n= 4 σ² L² Example: 1.mean pulse rate=70 Pop. Standard deviation(σ)=8 beats Calculate sample size? 2. Mean SBP=120,SD=10, calculate n? Sample size • Qualitative data • N=4pq L² e.g.