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Animal Trait Ontology A Project for the Creation of a Unified Trait Vocabulary for Farm Animals L. Hughes, J. Bao, Z.-L. Hu, V. Honavar, J.M. Reecy Iowa State University Overview • Clientele • How we got started • Collaborative Ontology Building • Animal Trait Ontology Classification of Traits Body trait AFE EWt_to EN_to AFE MD_R GR %SF BWt BWt %CARCASS MD_R EN_to BWt BWt %AF BWt BWt GR Chicken Chr1 Infectious disease Reproduction female AIMS • Form a collaborative group to develop an Animal Trait Ontology (ATO) – Include trait information for the pig, chicken, cow, and other farm animals • Form a collaborative effort between the ATO and other species ontology’s • Create a database that will allow the linkage of the trait information for each species stored in the ontology to its qtl/gene expression/proteomic information Classification of Traits - Mammalian Phenotype Ontology (MGI website) not suitable for production traits. - Define a 3 level Ontology based on the different publications : Body traits Carcass traits Fat % Abdominal fat weight Behaviour Abdominal fat weight Growth traits Immune response Meat quality Abdominal fat weight / BW Abdominal fat width Infectious disease Metabolic traits Fat distribution Muscular system Skin fat weight Metabolic disease Nervous system Skin fatness Reproduction Organs Plumage Skeletal system - Interactions between traits or traits belonging to different group : Thigh meat / bone ratio;meat color adjusted for body weight… Collaborative Ontology Building (COB) Editor • Each package can be independently developed • Different curators can concurrently edit the ontology on different packages • Ontology can be only partially loaded • Module access privileges can be controlled by the package hierarchy • Unwanted interactions are minimized by limiting term and axiom visibility Non-collaborative Ontology Building Download Ontology Local Editing Upload Ontology (single curator) (Protégé) (OBO-Edit) Modular Ontology: Example Collaborative building of an animal trait ontology that involves multiple research groups across the world Swine Horse Each group works on an ontology module for a particular species (according to the group’s best expertise) Cattle Chicken Package Nesting Animal trait ontology General Pig Pig Health • A nested package is a part of another package • Could be used to represent the organizational structure of an ontology – Arrange knowledge – Enforce hierarchical management of knowledge The COB Editor Pig Package Cattle Package Chicken Package ATO Reproduction Health Disease Resistance White Blood Cell Count Pathogen Salmonella Count in Liver Fertility Calving Ease Production Reproduction Traits Birth Weight Genetic Correlations Growth Daily Feed Intake Food Consumption Contributions • A unified vocabulary for farm animals phenotypic traits • COB Editor provides the necessary tool to collaboratively build well-structured, large-scale, biomedical ontologies • Higher order ontology terms that link species Acknowledgements Sanger Institute • Sean Humphray • Carol Scott • Jane Rogers UIUC Dept. of Animal Sci., ISU • Stacey Meyers • Jonathan Beever • Max Rothschild • Eric Ryan Fritz NCBI USDA-MARC • Svetlana Dracheva • Donna Maglott • Wonhee Jang • Gary Rohrer Funding Provided by USDA-CSREES