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Introduction Erik Segerdell Oregon Health & Science University RCN Meeting NESCent 25 February 2011 Xenopus Anatomy Ontology • XAO describes the anatomy and development of the African frog Xenopus • Used to annotate and search for gene expression patterns in Xenbase (www.xenbase.org) • OBO Foundry ontology, edited in OBO-Edit • Anatomical systems, cell and tissue types classified according to Common Anatomy Reference Ontology (CARO) • Lineage of tissues represented by develops from relationships, start and end stages Xenopus Anatomy Ontology eagle-i • Eagle-i: a prototype of a biomedical research resource discovery network • Data model designed in CMAP, implemented in Protégé • Re-use/coordination of existing terminologies • Upcoming challenges: enhancement of genotype and phenotype representation dx.doi.org/10.1038/npre.2010.5176.1 RCN Ontology Coordination • Help integrate ontologies at a high level as per the needs of the working groups and recommendations of the Advisory Board • Advise on best practices • Provide a ‘help desk’ function to new groups who are developing ontologies • Help with RCN website administration