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Cardiovascular System Introduction The heart pumps 7000 liters of blood a day Contracts 2.5 billion times in a lifetime This system brings oxygen and nutrients to all body cells and removes wastes Functioning system is vital for survival Structure of the Heart Heart is hollow, cone-shaped, muscular pump in the thoracic cavity and resting on the diaphragm. Heart size varies with body size. Average adult's heart is 14 cm long and 9 cm wide The pericardium encloses the heart The pericardial cavity contains serous fluid to reduce friction between the pericardial membranes Walls of the Heart Three distinct layers of the heart wall – – – Epicardium protects the heart by reducing friction. Myocardium middle layer consists of cardiac muscle tissue to pump blood out of the heart chambers The inner endocardium contains blood vessels and muscle fibers Heart Chambers and Valves Divided into four hollow chambers – – – – – Atria are the upper chambers; thin walls that receive blood Ventricles are the lower chambers that receive blood from the atria and contract to force blood out The right ventricle has a thinner wall and pumps blood to lungs The left ventricle has a thicker wall and pumps blood to other parts of the body Septum wall separates the atrium and ventricle on right side from the left side Atrioventricular valves (AV valve), is a tricuspid valve on the right; bicuspid valve on the left; ensures one-way blood flow between atria and ventricles Semilunar valves: the pulmonary valve prevents backflow into the right ventricle and aortic valve prevents backflow in the left ventricle. Path of Blood through Heart Blood low in oxygen and high in CO2 enters right atrium through the superior and inferior vena cava. The right atrial wall contracts pushing blood through the tricuspid valve entering the right ventricle The right ventricle contracts, the tricuspid valve closes, blood moves through pulmonary valve into pulmonary arteries towards the lungs. Gas exchange occurs in the lungs and the blood returns to the heart through the pulmonary veins to the left atrium. The left atrium contracts, pushing blood through the bicuspid valve into the left ventricle. The left ventricle contracts, closing the bicuspid valve and pushing blood through the aortic valve into the aorta to the body. Heart Actions Contraction of walls is systole while relaxation is diastole Atrial systole (contraction) while ventricular diastole (relaxation) and vice versa The atria and ventricles both relax for a brief interval. This series constitutes a heartbeat or cardiac cycle Heart Actions Cardiac Cycle Pressure within the heart chamber rises and falls, controlling the blood flow. The heartbeat heard through a stethoscope sounds like “lubb-dupp” These sounds are due to the vibrations in the heart tissue associated with the closing of the valves – – Lubb is ventricular contraction and AV valves closing Dupp is ventricular relaxation and pulmonary and aortic valves closing. Cardiac Conduction System The sinoatrial node (SA node) is a mass of specialized cardiac tissue beneath the epicardium. On the right atrium near the opening of the superior vena cava. – This initiates impulses that spread to stimulate muscle contraction in atria – Rhythmic, one pulse after another; 70-80 times/minute in adults – The Pacemaker ខ The atrioventricular nodes (AV node) is located in the septum and helps in contraction of ventricles Electrocardiogram ECG Recording of the electrical charges during the cardiac cycle The SA node triggers an impulse (P wave) The AV node triggers the QRS complex Used to assess the heart's ability to conduct impulses Show the time period of impulse travel between nodes Blood Vessels Closed circuit of tubes that carries blood Includes: – – – – – Arteries Arterioles Capillaries Venules Veins Arteries and Arterioles Arteries carry blood away from the heart under high pressure. These are subdivided into thinner tubes called arterioles. Vasoconstriction is the contraction of smooth muscles in the vessel , reducing the diameter Vasodilation is the relaxation of smooth muscle, increasing the diameter. Diameter influence blood flow and blood pressure Capillaries Smallest-diameter blood vessels Connect smallest arterioles to the venules Substances are exchanged within tissues with capillaries Diffusion, filtration, or osmosis occurs to/from capillaries from/to tissues Veins and Venules Venules are microscopic vessels off of capillaries and merge to form veins Veins carry blood back to the atria Veins also function as blood reservoirs Blood Pressure Force of blood exerted against the inner walls of blood vessels Commonly refers to arteries Systolic Pressure – max pressure during ventricular contraction Diastolic pressure – lowest pressure remaining in arteries before next ventricular contraction Factors Influencing BP Heart Action • How much blood enters the arterial system • Volume of blood from left ventricle with each contraction is stroke volume • Volume discharged from left ventricle per minute is cardiac output Blood Volume • Sum of formed elements and plasma volume in vascular system • Usually about 5 L for adults Peripheral Resistance • Friction between blood and the walls of blood vessels, hindering blood flow Blood Viscosity • Ease at which a fluids molecules flow past one another • The greater the viscosity, the greater the resistance to blood flow