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Figure 18.4 Interactions of Cells and Chemical Signals in Inflammation Splinter Skin Bacteria introduced by splinter Damaged mast cells release histamine. Histamine diffuses into the capillaries. Blood capillary Figure 18.4 Interactions of Cells and Chemical Signals in Inflammation Bacteria Phagocytes move into infected tissue. Activated complement proteins attract phagocytes. Histamine causes the capillaries to dilate and become leaky. Figure 18.4 Interactions of Cells and Chemical Signals in Inflammation Phagocytes engulf bacteria and dead cells. Dead cells Histamine and complement signaling cease, phagocytes are no longer attracted, and the tissue returns to normal.