Survey
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
* Your assessment is very important for improving the workof artificial intelligence, which forms the content of this project
Autosomal Dominance Inheritance What’s an Autosome? • Autosome: Non sex chromosome – Ex: Autosomal disorders: gene for the disease is found on chromosomes 1-22 • Autosomal Recessive Inheritance – Must inherit two copies of the disorder to be affected – Healthy is dominant (HH or Hh) – Disease is recessive (hh) – Ex: Cystic fibrosis, PKU, Albinism, Sickle cell anemia • Autosomal Dominance Inheritance – Only need to inherit one copy of the disorder to be affected – Disease is dominant (HH or Hh) – Healthy is recessive (hh) – Ex: Familial hypercholesterolemia (also called FH), Huntington’s disease, Neurofibromatosis Autosomal Dominance Inheritance • Disease is dominant (HH or Hh) – Homozygous dominant: early death and don’t survive to reproduce – Heterozygous live into adulthood • Healthy is recessive (hh) • ex: Paul has familial hypercholesterolemia and Stacy is healthy. The two have 3 children. After testing, the middle child is the only healthy child. Hh hh Paul Stacy Key disease disease H = FH disease h= healthy healthy healthy Hh hh Hh Autosomal Dominance Inheritance • Huntington’s disease is a dominant disorder found on chromosome 4. Betty and Marcus met at a support clinic they have been attending to help them cope with the knowledge of their illness with Huntington’s disease. They would like to know the risk of having a healthy child, now that Betty is pregnant. Hh Hh Marcus Betty Key Disease (severe) disease H = Huntington’s disease h = healthy disease healthy ? Woody Guthrie: This Land is Made for You and Me Video about Huntington's disease • Autosomal dominant disorder • Brain cells start to die in late 30’s • Causes uncontrollable muscle jerking • Death usually in 40’s-50’s • No treatments Click if YouTube video doesn’t work