Download The immunoglobulin-like genetic predetermination of the brain: the

The immunoglobulin-like genetic predetermination
of the brain:
the protocadherins, blueprint of the neuronal network
Review Article
Naturwissenschaften (2001)
,
N. Hilschmann
H.U. Barnikol et al.
2002. 1. 14. 25th MPL Lab. Seminar A-Ram Jeong
The Structure and function of protocadherins. Protocadherins are celladhesion molecules. Their morphogenetic capacity is accomplished by their
bipartite structure, which is very similar to that of classical cadherins. Besides
a transmembraneous section they have an N-terminal extracellular part
consisting of six domains and a C-terminal intracellular domain.
The protocadherin genes. We distinguish three classes of
protocadherins: alpha, beta and gamma. In the genome there are
three serially repeated V-gene sets, each followed by
corresponding C-genes.
Immunoglobulin gene translocation and expression
Protocadherin gene translocation and expression
The module system of the neuronal network
References
1. Recent progress in protocadherin research
Experimental Cell Research 261, 13-18 (2000)
2. Phylogenetic analysis of the cadherin superfamily allows identification
J. Mol. Biol. (2000) 299, 551-572
3. Protocadherins and diversity of the cadherin superfamily
Journal of Cell Science 109, 2609-2611 (1996)
4. Cadherin superfamily genes: functions, genomic organization, and neurologic Diversity
GENES & DEVELOPMENT 14:1169–1180 (2000)