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PGXL Panels August 2013 Kristen K. Reynolds, PhD VP Laboratory Operations Copyright 2012-2013PGXL Laboratories, Louisville KY All materials herein are the exclusive property of PGXL Laboratories Physician information on top Single gene orders and ABN annotation Single req form for all medical specialties Panels revised based on ABN and common orders Key Service Lines Pain Management – opioid resistance and opioid toxicity Behavioral Health – Drug selection to manage treatment resistant depression and psychosis – Dosing information to minimize adverse drug reactions Anti-platelet therapy – Clopidogrel resistance and increased bleeding risk Thrombotic risk assessment Statin therapy (ABN) – Minimum effective statin dose and myopathy risk Anti-coagulant therapy (ABN) – warfarin dose estimation and optimal INR interpretation guidance Single Genes 2D6 2C19 MTHFR FII FV All genes orderable individually *requires ABN 3A4* 3A5* 1A2* 2C9* VKORC1* OPRM1* SLC6A4* SULT4A1* SLCO1B1* Pain Management Pain Management Opioid Sensitivity 2D6 Add OPRM1* Add SLC6A4* *requires ABN Comprehensive Pain 2D6, 2C19, 2C9*, OPRM1* Add SLC6A4* Applications in Pain Opioid prodrug efficacy/ADR: 2D6 Active opioid dose: OPRM1* NSAID ADR: 2C9* Other opioids and muscle relaxers: 2C19, 3A4*/3A5*, 1A2* Methadone: 2C19 (active portion) Cardiology Cardiovascular Health Warfarin 2C9*, VKORC1* Comprehensive CV Panel 2D6, 2C19, 2C9*, VKORC1* Clopidogrel 2C19 Thrombophilia Panel FII, FV, MTHFR Arrhythmia/Hypertension 2D6 *requires ABN CV panels have no statin tests? • All current statin tests require ABN 3A4, 3A5, 2C9, SLCO1B1 • All orderable as single genes at the top of the req form Clopidogrel guidelines update 2013 Deepening the evidence base • Updated literature review • New section on CYP2C19 sequencing and novel variants. This includes the novel *4B misclassification issue PGXL addresses in our recent abstract accepted to AMP 2013. • New section on novel candidate genes. • New section on who could be considered for CYP2C19 genotyping. Re-focus recommendations on patients with acute coronary syndromes undergoing PCI. • Updated data linking CYP2C19 genotype to phenotype. • Still no recommendations to increase dose in IMs. Discussion about how doubling the dose is not always enough in IMs and may need to be higher than 150mg/day, but no complete data for that yet Scott et al 2013 Behavioral health Behavioral Health Basic Psychiatry Panel 2D6, 2C19 Add SLC6A4* Add SULT4A1* Add MTHFR *requires ABN STA2R Panel 2D6, 2C19, 2C9*, 3A4*, 3A5*, 1A2*, SULT4A1*, SLC6A4*, MTHFR Basic Psychiatry Panel 2D6 and 2C19 account for many of the most common antidepressants and antipsychotics Add SLC6A4* Add SULT4A1* Add MTHFR *requires ABN SSRI sensitivity/resistance olanzapine efficacy L-methyl folate supplementation Suregene Panel = 9 genes, 6 of which require ABN Available as full panel or single genes Thank You [email protected]