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Nutrition Vital Nutrients • The small intestine absorbs all the nutrients required for life • Some nutrients are required for energy and for building blocks for more cells and cell parts – Carbohydrates – Proteins – Lipids • Other nutrients are required for homeostasis but not energy – Water – Vitamins – Minerals Carbohydrates • A single carbohydrate molecule is called a simple carbohydrate or a monosaccharide (such as glucose) – Starches are made of many bound together and are called complex carbohydrates – Some are more complex than others, and the more complex the branching, the longer the digestion takes • “White” starches such as white rice and pasta contain simpler chains Glycemic Index • The faster a food breaks down into glucose molecules, the higher the glycemic index – Pure glucose has a glycemic index of 100 • People with diabetes and pre-diabetes must eat only foods with lower glycemic indices so as to not spike the blood sugar – People with a family history of diabetes should probably do so as well… Insulin Spike • Insulin is released in response to glucose – Insulin stimulates the liver and fat cells to absorb glucose • A rapid release of glucose followed by an insulin spike can cause the blood sugar to crash Indigestible Carbohydrates • Some branch-chain carbohydrates are completely indigestible to humans (such as cellulose) • These are still useful to the body as dietary fiber – They add mass to your food (causing you to eat less overall) – They retain water in the feces, making it easier to pass Proteins • Proteins must be broken down to the individual amino acids • The human body can synthesize many of the amino acids from other amino acids (so they are nonessential), but there are certain ones that cannot be synthesized – These are called essential amino acids • If even one of the essential amino acids is missing, the diet is incomplete and no new protein can be made Lipids • There are many classes of lipids – Some vitamins (A, D, E, K) and cholesterol are lipids, but cannot be burned for energy • The energy-storing lipids are fatty acids, and these fats can be saturated or unsaturated – Saturated fats have no double bonds and so pack together more tightly than unsaturated fats – Treating unsaturated fats with hydrogenation can create trans fats, which are very difficult to metabolize and therefore very unhealthy Vitamins and Minerals • Vitamins are organic compounds that serve key purposes in cell mechanisms but only in small amounts – Example: vitamin A used in your retina • Minerals are inorganic elements and compounds, such as sodium, potassium, calcium, iron, and iodine – Also necessary for life Sample Vitamins and Minerals • Vitamin A: used in the retina, can be synthesized from carotene (in carrots and tomatoes); deficiency can result in blindness • Vitamin D: important for bone growth, produced by sunlight on skin from cholesterol; deficiency called rickets • Vitamin C: found in citrus fruits, boosts collagen production and immune system function; deficiency called scurvy • Niacin: vital for processing energy-storing molecules; deficiency called pellagra • Sodium: Vital for maintaining osmotic balance and key component of action potentials • Potassium: Vital for action potentials, must be in proportion to sodium • Iron: Used in hemoglobin, lack of iron in diet results in irondeficiency anemia • Iodine: A key component of the thyroid metabolic hormones T3 and T4 (thyroxine) • Zinc: functions as a cofactor in many metabolic enzymes Alcohol Dehydrogenase • The liver must metabolize alcohol into acetic acid using an enzyme called alcohol dehydrogenase – This requires energy and uses some of the liver’s resources – Most women and some ethnic groups such as East Asians have less enzyme, making them have a lower tolerance for alcohol • Acetic acid can then either be converted to fat or burned for energy as needed Dietary Proportion • Opinions vary wildly on the “optimal” dietary proportions of carbs, proteins and fats • A major reason for this is the different efficiencies of enzymes in different people – Genetics in action! – What is healthy for one person may be unhealthy for another! Example of Enzyme Action • Carbohydrates and lipids are interconvertible, meaning carbs can be changed to lipids and vice versa – These are accomplished using enzymes • If a person’s enzymes to change carbohydrates into lipids are more efficient, then that person may preferentially build fat more than someone else – Someday genome sequencing will make nutrition much more personalized Essential Macronutrients • New cells must be formed every day – Mostly epithelial cells (skin, GI tract, etc) and blood cells • All cells require fat (cell membrane) and protein (for cell structures) – Carbohydrates are also used structurally for skin glycoproteins – Carbohydrates are also used as the energy source for mitosis Nutrient Use Friday: Metabolism! • Then kidneys, then reproduction, then no new lessons!