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Transcript
Most of us Coding DNA Jeremy --------T G G ------ --------T G T ------ --------A C C ------ --------A C A ------ Messenger RNA --------U G G ------ --------U G U ------ Amino Acid --------TRYPTOPHAN ------ Template DNA --------CYSTEINE ------ These guys also carry mutations…apparently --------T G T ----------T G G ---- With point mutation G to T ie a substitution X Man Jeremy Most of us ISO ISO The offending amino acid LEU LEU ALA ALA CYS TRY ASP ASP ISO ISO PRO PRO Blimmin X Men everywhere What would be the result if the mutation was a substitution of the G to a C ? -----T G G ----Most of us ISO ISO LEU LEU ALA ALA ? TRY Don’t forget to go: …coding DNA …template DNA …mRNA …A A ? ASP ISO PRO ? ? Original TGG Coding DNA Template DNA mRNA Amino Acid With MUTATION TGC ACC ACG UGG UGC Try Cys What the… That is the same as Jeremy How come? There are 64 codons and 20 amino acids, that’s how come The answer... X Man Jeremy Most of us ISO ISO LEU LEU ALA ALA CYS TRY ASP ASP ISO PRO ISO PRO So no change then !!! -----T G c ------ will still give CYS What would be the result if the mutation was a substitution of the G to an A ? -----T G G -----Most of us ISO ISO LEU LEU ALA ALA ? TRY ? ASP ISO PRO ? ? The answer... Most of us ISO ISO LEU LEU ALA ALA STOP! TRY ASP ISO PRO A non-sense mutation. It will make a very short protein Most likely with no function
