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Protein Synthesis From DNA to Proteins! What is a gene? A small segment of DNA that provides instructions for making proteins QuickTime™ and a decompressor are needed to see this picture. Gene QuickTime™ and a decompressor are needed to see this picture. What is a protein? Amino acids (monomers) linked (bonded) together! QuickTime™ and a decompressor are needed to see this picture. From DNA (gene) to protein? The nucleotide order is copied in the nucleus into a message (mRNA) = Transcription (DNA stays in the nucleus) The “messengerRNA” is sent to the ribosome C =G G=C T=A A=U QuickTime™ and a decompressor are needed to see this picture. Transcription QuickTime™ and a decompressor are needed to see this picture. QuickTime™ and a decompressor are needed to see this picture. Proteins are made in the ribosomes! Three nucleotides (bases) make a “codon” Each codon is a message to bring in one amino acid (using tRNA) The amino acids are linked together to form the protein QuickTime™ and a decompressor are needed to see this picture. Translation QuickTime™ and a decompressor are needed to see this picture. Practice! In RNA, U (uracil) is substituted for T (thymine) DNA = GGG CCC ATA mRNA = CCC GGG UAU Amino Acid = Pro Gly Tyr QuickTime™ and a decompressor are needed to see this picture. Examples of proteins Sucrase (breaks down sucrose / sugar) Helicase (unwinds DNA during replication) Keratin (hair and nails) Melanin (pigment in skin, hair and eyes) Collagen (found in tendons and skin) Insulin (regulates blood sugar) Antibodies (fight invading bacteria) Myosin (main protein of muscle fiber) P53 (tumor/ cancer suppressor) QuickTime™ and a decompressor are needed to see this picture. QuickTime™ and a decompressor are needed to see this picture.