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1 How do drugs work??? Nerve cells in the brain are called neurons. These neurons "talk" to each other by passing chemicals back and forth, just like passing notes in class. The neurons' "notes" are called neurotransmitters, and they are manufactured in vesicles in the nerve cell. Neurotransmitters include serotonin, acetylcholine, norepinephrine, dopamine, histamine and about two dozen others. 2 How do drugs work??? The nerve cells are separated by a small space called a "synapse." When a message moves down the axon of the pre-synaptic neuron, neurotransmitters are released from the vesicle. These chemicals (or notes) cross the synapse to the post-synaptic neuron, where they bind with receptors specifically designed to receive them, much as a key is designed to fit into a specific lock. 3 How do drugs work??? Many nerve cells have receptors that are sensitive to various drugs. These drugs operate on the "lock-and-key" principle, where the drug can be thought of as the "key" that either (1) fits into the "lock," causing the nerve cell (neuron) to discharge its chemicals, or (2) "jams" the lock, preventing the nerve cell from discharging. 4 How do drugs work??? Ex.) -Narcotics mimic endorphins and lock into opiate receptor sites. - Hallucinogens mimic serotonin - Cocaine blocks the re-uptake of neurotransmitters → causing severe depression when coming down. - Methamphetamines cause the release of neurotransmitters in greater amounts - THC mimics anandamide and interferes with the cannabinoid receptor sites. 5 What is a Drug? Drug – any chemical other than food intended to affect the structure or function of the body. 6 Why some people use Drugs? Many people believe that every problem, no matter how large or small, has or should have chemical solutions. Examples: For fatigue = caffeine For insomnia = sleeping pills For anxiety or boredom = alcohol/drugs 7 Health Consequences of Drug Use Physical Consequences- Once a drug enters the bloodstream, it can harm a user’s brain, heart lungs, and other vital organs. Mental & Emotional Consequences- drugs cloud reasoning and thinking, and users lose control of their behavior. (lose sight of values) Social Consequences- substance abuse can have negative effect on relationships with friends and family members. List examples: 8 DRUG USE… A HIGH RISK BEHAVIOR!! Substance abuse is a high risk behavior that includes misusing legal drugs or using illegal drugs or other chemicals People abuse drugs for a number of reasons, none of them healthful! 1. Teenagers – the highest percentage of use is with people between the ages of 18-25 9 Why do teenagers abuse drugs??? • A way to be accepted with peers • Influenced by the media • Curious • A way of rebelling • Escape pressures - Adults? - Athletes? 10 What is the difference between drug use and abuse? 1. 2. 3. Misuse Using the drug incorrectly due to ignorance Taking the drug with the wrong food Stopping the drug too soon Abuse 1. intentionally misusing the drug normally for a desired effect 11 Dangers of substance abuse Some drugs have side effects – can range from minor to deadly. Illegal drugs can be especially dangerous because there are no controls or means of monitoring these substances for quality, purity, or strength. 12 Dangers of drug abuse Overdose – is a strong or fatal reaction to taking a large amount of drug. Often, overdoses occur when alcohol and other drugs are combined. When drug abuse involves injecting substances through a needle, hepatitis B or HIV can occur People who experiment with drugs tend to lose control…can lead to STD’s or pregnancies 13 Dangers of substance abuse Risk to unborn and newborns: 1. breast milk – can pass from mother to infant. 2. Can cause miscarriage or premature birth 3. Can cause birth defect, mental retardation 14 CLASSIFICATIONS OF DRUGS (Psychoactive) Stimulants- Drugs that speed up activities of the central nervous system (CNS) Depressants- Psychoactive drugs that slow brain and body reactions. Narcotics (opiates)- natural or synthetic drugs that relieve pain and cause drowsiness. Inhalants- Drugs that are inhaled or breathed in through the nose to produce the desired effect. Hallucinogens- Psychoactive drugs that alter perception, thought, and mood. 15 CLASSIFICATIONS OF DRUGS cont. Prescription Medicines – cannot be used without the written approval of a licensed physician. Over-the-counter (OTC) medicines – you can buy these without a prescription 16 Psychoactive Drugs Psychoactive drugs – those designed to alter a person’s experiences or consciousness. (nicotine, heroin, cocaine, alcohol, steroids, LSD, marijuana) Psychoactive drugs cause intoxication Intoxication – a state in which sometimes unpredictable physical and emotional changes occur. A person who is intoxicated may experience a difference in emotions and judgment. 17 1. STIMULANTS Drugs which cause the body systems to speed up Effects: increased heart rate and breathing, increased blood pressure, dilated pupils, decreased appetite, dry mouth, dizziness, sweating, headache, blurred vision, sleeplessness, anxiety, moodiness Very high doses: irregular heartbeat, tremors, high fever, heart failure How it enters the body: swallowed, snorted, injected 18 STIMULANTS Amphetamines - people use them illegally to stay awake and alert, to improve athletic performance, to lose weight, etc. Methamphetamine – fumes alone can be deadly Cocaine – powerful stimulant – regular use can lead to depression, edginess, weight loss, and physiological dependence Con’t. use can destroy the nasal septum. Can cause heart attacks due to disturbing electrical impulses of the heart. Can occur on the first use! The drug, not the user, control the shots Crack - a form of cocaine 19 Stimulants –slang names Speed Uppers Crank Pep pills Medical use Treats hyperactive children Treats narcolepsy Used for weight control Bumble bees Hearts Footballs Christmas trees Black beauties 20 “Meth Mouth” Experts believe that meth ravages teeth by drying up saliva and leaving users with “dry mouths.” Without saliva, bacteria in the mouth multiply, leading to decay. Dentists report that healthy teeth can become rotten from even a few months of meth use. 21 22 Long- Term Effects of Meth Use Hallucinations Disorganized lifestyle Violent and aggressive behavior Permanent psychological problems Behavior resembling paranoid schizophrenia Poor coping abilities Disturbance of personality development Lowered resistance to illnesses Possible brain damage 23 24 25 2. DEPRESSANTS Depresses or slows down the central nervous system. alcohol can prove fatal. Users feel no pain or fear. Effects: similar to the effects of alcohol *small doses – calmness, relaxed muscles * larger doses – slurred speech, impaired judgment, impaired coordination *very large doses – respiratory depression, coma, death How it enters the body: swallowed 26 2. Depressants Medical use: to stop convulsions, relief of tension and anxiety, to induce sleep Slang names: yellow jackets, reds, red devils, blues, ludes, barbs, downers, yellows Drugs: barbiturates, tranquilizers, alcohol, methaqualone 27 3. Narcotics Powders ranging from white to dark brown; tablets, capsules, liquid. Comes from the poppy plant or it is synthetic Effects: stimulates a burst of euphoria, often followed by drowsiness, nausea and vomiting. Ravages the body and is extremely addictive. When paired with alcohol, heroin is easy to overdose on. 28 3. Narcotics Short term problems: breathing problems, nausea, vomiting, constipation Long term problems: users must take the drug to feel “normal.” A break of only one day can bring on severe withdrawal symptoms – aches, chills, sweating, muscle spasms and weakness. After a break, the usual dose may be an overdose Heroine is highly addictive. 29 3. Narcotics Medical use: pain relief, cough suppressant (codeine), pain relief, stops diarrhea, relief from tooth pain Morphine – used to reduce severe pain. Exa. Relief from cancer Slang names: smack, horse, brown sugar, junk, mud, big H, Miss Emma, schoolboy, dollies, blue velvet How it enters the body: injected, smoked or inhaled 30 3. Narcotics Heroin – has no accepted medical use in the US. Depresses the nervous system and slows breathing and pulse rate Coma or death may occur with large doses Tolerance develops quickly 31 4. HALLUCINOGENS (Psychedelics) Drugs that distort the senses and cause hallucinations Could appear as liquid, capsules, powder, blotter paper, thin gelatin squares, mushrooms Effects: time distorted, senses distorted, may produce bizarre, unpredictable behavior, person may sit for hours in a quiet dreamlike state 32 4. Hallucinogens Short term effects: a “bad trip” – intense panic, confusion, deep depression, terrors, scary delusions. Can cause fatal accidents Long term effects: Out-of-the-blue flashbacks – hallucinations without taking the drug again for up to a few days to a year after an acid trip. Severe depression All are illegal – 33 4. Hallucinogens PCP(angel dust) –considered to be one of the most dangerous of all drugs. Time seems to pass slowly, body movements slow down, coordination impaired, dulls the sensations of touch and pain. Mescaline – is the psychoactive ingredient of the peyote cactus. 34 4.Hallucinogens LSD – (acid) effects are widely unpredictable. Some users believe that they can fly LSD “acid” is odorless, colorless. Often added to absorbent paper, such as blotter paper, and divided into small decorated squares. 35 Hallucinogens The effects of LSD are unpredictable. Great mood swings, delusions and visual hallucinations. The user may “hear” colors and see sounds. Trips are long – 8 hours – multiple days. Some users experience severe, terrifying thoughts and feelings, fear of losing control, fear of insanity and death and despair. Flashbacks – occurs suddenly, often without warning, and may occur within a few days or more than a year after LSD use 36 ANABOLIC STEROIDS Powerful compounds that are similar to the male sex hormone, testosterone. These drugs are taken to increase muscle mass and strength Effects: may initially increase muscle mass, body strength, and weight, purple or red spots on the body, swelling of feet and legs, unpleasant breath odor, depression, increased risk of heart attack, stroke liver cancer, acne 37 Anabolic Steroids Males - sterility, withered testicles, impotence Females – irreversible masculine traits, breast reduction, sterility How it enters the body: swallowed, intramuscular injection Article 38 Steroids 39 40 INHALANTS Dangerous fumes are concentrated in a bag, on a cloth, etc. and inhaled Effects: nausea, sneezing, coughing, nosebleeds, fatigue, lack of coordination, loss of appetite, * solvents – decrease in heart rate and breathing, impaired judgment 41 Inhalants How it enters the body: Vapors are inhaled through the nose or mouth A person can go into a coma from a single use and be in a vegetable state the rest of his/her life 42 MARIJUANA The dried leaves, stems, and seeds of the cannabis sativa plant. Hashish is the dark brown resin that is collected from the top of this plant. Effects: increased heart rate, bloodshot eyes, dry mouth and throat, increased appetite, short-term memory loss, altered sense of time, damage to lungs and circulatory system How it enters the body: Smoked in joints, pipes, bongs, eaten 43 Marijuana Main active chemical in marijuana is THC. Marijuana’s effects on the user depend on the strength of the THC Cannabis is a hallucinogen and has the effects of both a depressant and a stimulant Alters your senses, coordination, reaction time, and can interrupt your ability to make rational and healthful decisions 44 Marijuana Short term effects: problems with memory and learning, distorted perception, difficulty in thinking and problem solving, loss of coordination, increased heart rate, anxiety, and panic attacks. Effects on the lungs: same respiratory problems that tobacco users have. (cancer, etc,) 45 CLUB DRUGS Are used by young adults at all-night dance parties such as “raves” or “trances,” dance clubs, and bars. Some club drugs are colorless, tasteless, and odorless. They can be added to beverages by individuals to intoxicate or sedate others. There has been an increase in reports of club drugs used to commit sexual assaults 46 Club Drugs Ecstasy (MDMA) - mind altering drug with hallucinogenic properties Health hazards: psychological difficulties, confusion, depression, sleep problems, drug craving, severe depression. Physical problems: muscle tension, nausea, blurred vision, chills, sweating Long term problems: damage to the parts of the brain critical to thought and memory 47 CLUB DRUGS GHB – is odorless and nearly tasteless. Induces a state of relaxation Can be slipped into someone’s drink without detection. Has been reportedly used in cases of date rape. Physical problems: nausea, vomiting, respiratory problems, seizures, coma 48 CLUB DRUGS Rohypnol – people may unknowingly be given the drug which, when mixed with alcohol, can incapacitate and prevent a victim from resisting sexual assault. Physical symptoms: sedative-hypnotic effects including muscle relaxation and amnesia. 49 Club Drugs Ketamine: “special k” is a powerful hallucinogen that includes visual distortions and a lost sense of time, sense and identity. Profound physical and mental problems including delirium, amnesia, impaired motor function and potentially fatal problems Special K is a powder that is usually snorted but is sometimes sprinkled on tobacco or marijuana and smoked. 50 Signs and Symptoms of Substance Abuse Emotionally/ Personality Behaviorally Physically/ Physical Appearance Social Activity/ School Performance 51 Emotional / Personality Effects of Substance Abuse Aggression Burnout Anxiety Depression Paranoia Denial Withdraws from family/ Friends •Extreme Mood Swings •Is secretive / Lying 52 Behavioral Effects of Substance Abuse Slow reaction time Impaired coordination Slowed Speech Irritability Excessive Talking Inability to sit still Limited attention span Poor motivation Lack of energy 53 Physical Effects of Substance Abuse Weight Loss Sweating Chills Poor Hygiene Interrupted sleep patterns < or > Loss of appetite 54 Social Activity Effect Drops old friends and activities Skipping School Loses interest in school work Low Grades Sleeping in class Loses concentration Having trouble remembering things 55 Addiction – what friends or family members can do Many families, after recognizing that the problem exists, will have an intervention. Intervention - the interruption of the addiction continuum before the addict hits bottom. Meetings take place without the addicted person’s knowledge. Second step in this process is a surprise meeting with the addict that forces the addict to face the seriousness of the problem. If addict refuses to recognize the problem, the addict will be given an ultimatum - Wife will move out, etc. 56 Recovery A process that happens over time -. A recovered person never says “I am cured, but “I am recovering.” The first step in the recovery process is detoxification – the removal of the drug from the body, usually under medical supervision This step also includes restoring one’s mental health Most experts recommend total abstinence Relapse – slips from recovery, or periodic returns to use can happen 57 Treatment options Support group such as AA, narcotics Anonymous, cocaine anonymous Detoxification Units – a person is under a Drs. care and may be given some medication to ease the symptoms of withdrawal Inpatient treatment centers – involves detox and counseling, both individual and group 58 Treatment options Outpatient treatment centers – involves follow up sessions, counseling Halfway housespeople are admitted to this program generally after they have completed at least a 28 day recovery program where they stay for 6 months to a year where they learn coping and living skills they will need when they return to society. 59 Choosing to be Drug Free! Learn to say “no!” *Give a reason (lie or truth) *Provide alternatives *Use eye contact to say no *Take a definite action Realize that no drug will solve your problem Talk to trusted friend/counselor, etc. Learn to handle the stress in you life and get help when you need it. 60 Refusal Skills Developing good self-esteem Have good eye contact Respond with a clear and firm "no" that does not leave the door open to future offers How you say no is as important as what you say. 61 Refusal Skills Identify the consequences ("We'll get in trouble.") Suggest an alternative Delaying Use humor Just say no 62