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Endocrine and Nervous Systems Regulate Digestion ï§ Gastrin â Causes release of gastric juice ï§ Secretin â Triggered by presence of acid in chyme â Stimulates pancreas to secrete water and bicarbonate ï§ Cholecystokinin (CCK) â Triggered by fat and protein in chyme â Signals pancreas to secrete digestive enzymes â Signals gallbladder to release bile © 2014 Pearson Education, Inc.