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LIPIDS: THE CONDENSED ENERGY CHAPTER 6 Copyright © 2015, 2010, 2005, 1998 by Saunders, an imprint of Elsevier Inc. Lipids: The Condensed Energy In 2006, added fats and oils provided more calories/day for the average American than any other food group NHANES data find that only 17% to 20% of population meets the guidelines of <30% of calories from fat Copyright © 2015, 2010, 2005, 1998 by Saunders, an imprint of Elsevier Inc. 2 Classification of Fats Simple lipids can be found in foods and in the body Triglycerides Fatty acids Structural lipids are produced by the body Lipoproteins Phospholipids From Patton KT, Thibodeau GA: Anatomy & Physiology, ed 8. St. Louis: Mosby, 2013. Copyright © 2015, 2010, 2005, 1998 by Saunders, an imprint of Elsevier Inc. 3 Classification of Fats: Simple Lipids Simple lipids Saturated fatty acids (SFAs) Primarily in animal products (meat and dairy) Implicated in causing in total and LDL cholesterol, causing an risk for CVD Barbara Cousins. In Thibodeau GA, Patton KT (eds): Anatomy & Physiology, ed 6. St. Louis: Mosby, 2007. Monounsaturated fatty acids (MUFAs) Primarily in plant foods (olive oil, canola oil, peanuts, pecans, almonds, avocados) HDL cholesterol, which has a protective effect for CVD Copyright © 2015, 2010, 2005, 1998 by Saunders, an imprint of Elsevier Inc. 4 Classification of Fats: Simple Lipids Trans fatty acid Found in meats, dairy, stick margarine, shortening, salty snacks, high-fat baked goods, commercial frying fats High intakes result in elevated total and LDL cholesterol FDA requires food labels to declare the amounts of trans fat on nutrition labels Copyright © 2015, 2010, 2005, 1998 by Saunders, an imprint of Elsevier Inc. 5 Classification of Fats: Simple Lipids Polyunsaturated fatty acids (PUFAs) Essential fatty acids (EFAs) Linoleic acid (omega-6 FA)—coldwater marine fish, soybean and canola oils, leafy vegetables Involved in development and function of retina and cerebral cortex HDL is protective for CVD Linolenic acid (omega-3 FA)—vegetable oils like corn, safflower, soybean, sunflower Barbara Cousins. In Patton KT, Thibodeau GA: Anatomy & Physiology, ed 8. St. Louis: Mosby, 2013. Functions in growth, reproduction, and maintenance of skin integrity May risk of CVD Copyright © 2015, 2010, 2005, 1998 by Saunders, an imprint of Elsevier Inc. 6 Classification of Fats: Compound Lipids Phospholipids make up 40% of cell membrane (e.g., enamel and dentin) Synthesized in the body or obtained from the diet Lipoproteins transport insoluble fats in the blood High-density lipoproteins (HDLs) Low-density lipoproteins (LDLs) Very-low-density lipoproteins (VLDLs) Chylomicrons Cholesterol Precursor for hormones and structural component From Patton KT, Thibodeau GA: Anatomy & Physiology, ed 8. St. Louis: Mosby, 2013. Copyright © 2015, 2010, 2005, 1998 by Saunders, an imprint of Elsevier Inc. 7 Physiological Roles Concentrated source of energy Spares protein Satiety value Palatability Aids absorption of fat-soluble vitamins Provides EFAs Adipose tissue serves as an energy reserve Cushions vital organs Provides insulation and maintains body temperature Copyright © 2015, 2010, 2005, 1998 by Saunders, an imprint of Elsevier Inc. 8 Dietary Fats and Dental Health Decreased incidence of caries through the following: Inhibits streptococcal growth May reduce dissolution of hydroxyapatite by acids Fat may act as a protective layer and prevent adherence of retentive CHOs or enhance clearance May delay gastric emptying, enhancing fluoride absorption From Darby ML, Walsh MM: Dental Hygiene: Theory and Practice, ed 3. St. Louis: Saunders, 2015. Copyright © 2015, 2010, 2005, 1998 by Saunders, an imprint of Elsevier Inc. 9 Dietary Fats and Dental Health Periodontal disease Studies using 3000 mg of n-6 PUFA and n-3 PUFA n-6 PUFA gingival inflammation (significant at p <0.016 level) in levels of prostaglandins, arachidonic acid, and leukotrienes in pocket depth with n-3 (fish oil) and n-6 (borage oil) Copyright © 2015, 2010, 2005, 1998 by Saunders, an imprint of Elsevier Inc. 10 Dietary Requirements AMDR for total fat 20% to 35% of energy intake Keep intake of saturated fat, trans fat, and dietary cholesterol as low as possible while still consuming a nutritionally adequate diet AI for alpha-linolenic acid = 1.1 to 1.6 g/day AI for linoleic acid = 12 to 17 g/day Copyright © 2015, 2010, 2005, 1998 by Saunders, an imprint of Elsevier Inc. 11 Sources Principal sources of fat in US diet Fats and oils Red meats, poultry, and fish Dairy products Combined these sources account for about 90% of total fat intake Copyright © 2015, 2010, 2005, 1998 by Saunders, an imprint of Elsevier Inc. 12 Overconsumption and Health-Related Problems Obesity Excessive fat stores is a common disorder Blood lipid levels (hyperlipidemia) Strongest dietary determinant of the blood cholesterol level is dietary saturated fat Trans fats increase risk of CVD twofold to 10-fold Cancer Possible link to high-fat diet, but research continues Copyright © 2015, 2010, 2005, 1998 by Saunders, an imprint of Elsevier Inc. 13 Underconsumption and Health-Related Problems EFA deficiency Symptoms include dry, scaly, skin; hair loss; impaired wound healing; visual impairment; and impaired reproductive ability People at risk People w/fatty malabsorption syndromes (e.g., cystic fibrosis) Premature babies Very low-fat diets (<10% of calories from fat) Copyright © 2015, 2010, 2005, 1998 by Saunders, an imprint of Elsevier Inc. 14 Fat Replacers Method to reduce fat intake National survey found 88% of US population consumes low-fat, reduced-fat, or fat-free foods and beverages Types of fat replacers Fat “substitutes” or “analogs” Contain less energy than fat “Fat mimetics” Mimic properties of fat Fat “barriers” Reduce absorption of fats during frying Copyright © 2015, 2010, 2005, 1998 by Saunders, an imprint of Elsevier Inc. 15 Fat Replacers: Classifications Carbohydrated~Plant polysaccharides Protein-based~Simplesse Fat-based~Olean Copyright © 2015, 2010, 2005, 1998 by Saunders, an imprint of Elsevier Inc. 16 Nutrition Considerations Wise choices of dietary fats When selecting and preparing meat, poultry, dry beans, and milk or milk products, choose lean, low-fat, or fat-free Limit intake of fats and oils high in saturated and/or trans fatty acids; choose products low in these If solid fat is added in cooking, this counts as part of discretionary calorie allowance Select fish rich in omega-3 fatty acids, such as salmon, trout, and herring Copyright © 2015, 2010, 2005, 1998 by Saunders, an imprint of Elsevier Inc. 17 HEALTH APPLICATION Hyperlipidemia Discuss major health risks associated with hyperlipidemia Consider optimum levels of LDL/HDL/triglycerides and patient actions for achieving them What dietary recommendations might a health provider make for patient’s reduction of hyperlidipemia? Copyright © 2015, 2010, 2005, 1998 by Saunders, an imprint of Elsevier Inc. 18