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MAT 501 PROBABILITY, RANDOM VARIABLES AND STOCHASTIC PROCESSES [4-0-0-4] Probability theory: Review of Set theory; introduction to probability, axioms of probability; joint and conditional probability; Bayes theorem. Random Variables: The concept of a random variable (RV); continuous and discrete RVs; probability distribution and density functions, properties; some standard examples; Functions of an RV, distribution and densities of functions of an RV, examples; expected value/mean and variance; moments and characteristic functions; two RVs: joint distribution and density functions; correlation, covariance, orthogonality and independence; conditional distribution and density functions. Elements of Estimation theory: Estimation of mean and variance; Chebyshev inequality; Parameter Estimation, Properties of Estimators; Cramer-Rao bound. Stochastic Processes: Introduction, Statistics of stochastic processes, correlation and covariance; Stationarity; Autocorrelation, Power density spectrum, and Wiener Khinchin Theorem; Linear Systems with stochastic inputs. References: 1. A. Papoulis and S.U. Pillai, Probability, Random Variables and Stochastic Processes, McGraw Hill, 2002. 2. P. Z. Peebles Jr., Probability, Random Variables and Random Signal Principles, McGraw Hill International Edition, 2001, Singapore. BME 501 ANATOMY AND PHYSIOLOGY [4-0-0-4] PART-A ANATOMY Cell and its constituents, Basic Tissues of Body (General), Muscular Tissue (detail), Major Muscles of the Body, Nervous Tissue, Brain, Spinal Cord, Meninges, PNS, Bone Tissue - Structure, Development and Growth, Fracture healing, Bones of Appendicular and Axial Skeleton System in brief, Joints Classification and Types, Movement at Joints, Respiratory System - Parts and Structure of Lungs, Urinary System - Kidney, Ureter, Bladder, Digestive System – Parts, Special Senses - Eye, Ear, Nose and Skin, Cardio Vascular System - Heart - Chambers, Blood supply and Nerve supply. PART B –PHYSIOLOGY Resting Membrane Potential and Action Potential. Synaptic Transmission EEG, Sensory System - Receptor potential, Transducer Function, Sensory Coding, Peripheral Nervous System - Organisation, Reflex Action and Circuits, Skeletal Muscle-Contraction process, Isotonic and Isometric Contractions Lever Systems. EMG, Motor Control - Major Controlling Systems (Cerebella, Basal Gangila, Cerebral Cortex), Regulation of Metabolism: major metabolic Process and their Hormonal Control, Cardio Vascular System- Principles of Hemodynamics, Cardiac Pump, Pressure, Resistance, Flow and Regulation, ECG Principles, Respiratory System Organisation, Functional Anatomy. Ventilation, Exchange, Transport, Feedback Regulation, Spirometry, Principles of Artificial Respiration, Cardio Respiratory Changes in Muscular Exercise, Renal System- Outline of Kidney Functions, Micturation, Cystometrogram, Species Senses- Visual Functions, Camera Principle, Refractory Errors and Correction, Perimetry. EarMechanics of Hearing. Tests for Hearing and Audiogram. Sense of Taste and smell. Reference Books: 1. Vander, Shuman and Luciano, "Human Physiology" Tata McGraw Hill. 2. Schmidt,"Text book of Human Physiology". 3. R.J.Last,"Human Anatomy". BME 503 BIO-INSTRUMENTATION [4-0-0-4] Study of Bio-electric signals & Electrodes, Transducers, Blood pressure & Blood flow measurements; Study of therapeutic equipments: Pacemakers, Diathermy, Haemodialyser, Lithotriptor, Anesthesia machine, Ventilator, Infusion pump, Infant Incubator; Study of Surgical devices: ESU, LASER & Endoscope; Cardiac-assist devices: Heart lung machine & Defibrillator; Study of Audiometer & Hearing-aids; Medical Imaging Systems: Ultrasonography, Thermography, X-ray Image Intensifiers: Construction, Intensifying action of screens; Introduction to Flat Panel detectors; Pulse Oximetry: Introduction, other methods to determine oxygen saturation of blood, major parts of pulse oximetry, applications of pulse oximetry. Reference Books: 1. R.S.Khandpur, ”Handbook of Biomedical Instrumentation” Tata McGraw Hill,1980. 2. Leslie Cromwell, et.al., ”Bio Medical Instrumentation”PHI,1990. 3. Geddes and Baker, ”Principles of Applied Bio-Medical Instrumentation”John Wiley,1989. 4. J.G.Webster, ”Medical Instrumentation, Application and Design” Houghton Miffin Co. Boston. 5. R. Aston,”Principles of Biomedical Instrumentation and Measurement” Merril Purl Co.1991. BME 505 BIOMEDICAL SIGNAL PROCESSING [3-1-0-4] Mathematical preliminiaries: Signals and systems,Z Transforms, Fourier transforms, Digital Filters, Elements of estimation theory, Power Spectrum estimation: Introduction, Periodogram, Welch method, AR, Moving average (MA), ARMA methods, Maximum likelywood method (MLM). Cepstrum analysis,complex cepstrum, homomorphic filtering, Introduction to Adaptive filtering- General structure of Adaptive filters, least mean square (LMS) adaptive filter, Adaptive noise canceling, Improved adaptive filtering, General characteristics of Biomedical Signals – Action potential, ECG, EMG, EEG, PCG, ENG, ECG QRS Detection -Power spectrum of ECG, Bandpass filtering techniques, Differentiation, template-matching, QRS detection Algorithm, STSegment analyzer. Reference Books: 1. Arnon cohen, “Biomedical Signal Processing” Vol 1& 2, CRC Press 1986. 2. Willis J Tompkins, “ Biomedical Digital signal Processing” Prentice Hall India ltd , 2001. 3. Metin Akay, “Biomedical Signal Processing” Academic Press. 4. Rangaraj M Rangayyan, “Biomedical Signal Analysis – A case study” John Wiley and Sons. 5. A. V. Oppenheim and R. W.Schafer, Digital Signal processing, Prentice Hall India Ltd, 1991. BME 507 BIO-MECHANICS & BIO-DYNAMICS [4-0-0-4] Introduction to biomechanics, Kinematic concepts for analyzing human motion, kinetic concepts for analyzing human motion, Linear and Angular Kinematics of human movement, Linear and Angular Kinetics of human movement. Application of Biomechanics to Neuromuscular fitnessAspects of fitness, Resistance devices used in training, Strength, Muscular power and Endurance, Flexibility. Application of Aerodynamics in Sports- Aerodynamic drag force, Effects of drag on the body and objects in sports, Aerodynamic Lift force, Effects of Lift on projected objects and the body, Lift force produced by Spin: The Magnus effect. Application of Hydrodynamics in swimming- Buoyancy and Floatation, Resistance and Propulsion, Resistive forces in swimming skills, propulsive forces in swimming skills, Swimming efficiency and Speed. Applications of Biomechanics (Qualitative Analysis) with regard to Physical Education, Coaching, Strength & Conditioning, Sports Medicine and Rehabilitation. Reference books: 1. Duane Knudson, Fundamental of Biomechanics, Kluwer Academic/Plenum Publishers. 2. Ellen Kreighbaum, Katharine M Barthels, Biomechanics-A Qualitative Approach for Studying Human Movement Macmillion Publishing Company second edition. 3. Susan J. Hall, Basic Biomechanics. HSS 501 Research Methodology and Technical Presentation [1 0 3 2] Mechanics of Research Methodology- Types of research, Significance of research, Research framework, Case study method, Experimental method, Sources of data, Data collection using questionnaire, Interviewing, and experimentation. Research formulation- Components, selection and formulation of a research problem, Objectives of formulation, and Criteria of a good research problem. Research hypothesis- Criterion for hypothesis construction, Nature of hypothesis, Need for having a working hypothesis, Characteristics and Types of hypothesis, Procedure for hypothesis testing. Sampling Methods- Introduction to various sampling methods and their applications. Data Analysis- Sources of data, Collection of data, Measurement and scaling technique, and Different techniques of Data analysis. Thesis Writing and Journal Publication-Writing thesis, Writing journal and conference papers, IEEE and Harvard styles of referencing, Effective presentation, Copyrights, and avoiding plagiarism. References: 1. Dr Ranjit Kumar, Research Methodology: A Step-by-Step Guide for Beginners, SAGE, 2005. 2. Geoffrey R. Marczyk, David DeMatteo & David Festinger, Essentials of Research Design and Methodology, John Wiley & Sons, 2004. 3. John W. Creswel , Research Design: Qualitative, Quantitative, and Mixed Methods Approaches, SAGE, 2004 4. Suresh C. Sinha and Anil K. Dhiman, Research Methodology (2 Vols-Set), Vedam Books, 2006. 5. C. R. Kothari, Research Methodology: Methods and Techniques, New Age International Publisher, 2008. 6. Donald R Cooper & Pamela S Schindler, Business Research Methods, McGraw Hill International, 2007. 7. R. Pannershelvam, Research Methodology, Prentice Hall, India, 2006 8. Manfred Max Bergman, Mixed Methods Research, SAGE Books, 2006. 9. Paul S. Gray, John B. Williamson, David A. Karp, John R. Dalphin, The Research Imagination, Cambridge University press, 2007. 10. Cochrain & Cox, Experimental Designs, II Edn. Wiley Publishers, 2006. BME 511 INSTRUMENTATION LAB [0-0-6-2] Study of the characteristics of Capacitive pickup transducer, Inductive pickup transducer, pressure cell, Strain sensor, RTD transducer, Linear Variable Differential Transformer (LVDT), Hall effect transducer, LDR / Phototransistor and photodiode, load cell, thermocouple, DC serve motor control, voltage to frequency converter; Realization of a Pacemaker circuit and Instrumentation amplifier. Demonstration: Study of Electrocardiograph and determining the cardiac vector; study of Audiometer and Air conduction thresholds testing; study of Blood Pressure meter, Defibrillator, Electrosurgical unit (ESU), Phonocardiograph and to visualize the heart sounds. Design and implementation of circuits with biomedical applications like QRS detector, Hearing aids, Digital thermometer etc.