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Attachement B no. Scientific Responsible 1/B Dott.ssa Romina Combi 2/B Dott. Roberto Giovannoni 3/B Dott.ssa Maria Foti 4/B Prof. Guido Cavaletti 5/B Dott.ssa Paola Marmiroli 6/B 7/B Dott.ssa Gaia Roversi Prof.ssa Clementina Cocuzza DEPARTMENT OF INTERDISCIPLINARY MEDICINE AND SURGERY Research grants allocated no. 4 Scientific field Sector Competition Reference Biological sciences NeurosciencesNeurobiology Medical sciences Medical sciences Biological sciences Biological sciences DSS Scientific Subject Title Synthetic Description Curricular requirements BIO/13 Identification and study of novel genes involved in Restless Legs Syndrome The aim is to search for new genes/mutations involved in RLS starting from the study of a large Italian family with 19 affected individuals. The identified mutations will be functionally characterized by creating in vitro models Experience in molecular/cellular biology and a PhD related to the project matter (Biology, Molecular Medicine, Biochemistry or similar) are requested A combination of anti-inflammatory human genes will be over-expressed in in vitro models (porcine Molecular mechanisms of Medical sciences-Medicine MED/04 cytoprotection in experimental endothelial cells) and in vivo (transgenic mice). models of xenotransplantation The mechanisms of cytoprotective response will be investigated at phenotypic and molecular level Medical sciences-Other Previous research experiences in cellular biology, genetic engineering and transgenic mice strains characterization The research project aims to study the molecular Innate Immunity and Multiple Experiences requested:-molecular and and cellular mechanisms underlying the Sclerosis: Molecular and cellular immunology;- dendritic and/or MED/04 inflammatory process in Multiple Sclerosis cellular mechanisms of mesenchymal cell biology;focusing on the development of new therapies that inflammatory diseases chronic inflammation utilize mesenchymal cell and dendritic cells Pathogenesis of chemotherapy-induced peripheral neurotoxicity (CIPN) The research project will be focused on the investigation of the basic mechanisms undelying CIPN in relevant in vivo animal models investigated with a multidisciplinary approach Demonstrated expertise in in vivo animals studies and in the use of mophological, neurophyisiological and behavioral assessment methods Neurosciences-Other BIO/16 Neurosciences-Other The research project will be focused on the Demonstrated expertise in in vivo Aging and peripheral nervous investigation of the role of aging under physiologic animals studies and in the use of BIO/16 system and pathologic conditions in relevant in vivo mophological, neurophyisiological and animal models behavioral assessment methods Medical sciences In the project familial and sporadic papillary thyroid Competences in human genetics, cancers will be investigated by applying to familial cellular and molecular biology ( in Searching for new genes particular about array CGH), and in Medical sciences-Medicine MED/03 involved in the pathogenesis cases array CGH, linkage analysis and/or exome sequencing and to sporadic cases molecular of papillary thyroid carcinoma use of the major genome browsers are biology/cytogenetic techniques required Medical sciences Role of HPV viral load and of Medical sciences-Medicine MED/07 immunity in cervical dysplasia progression To investigate the complex interaction between HPV and host in the natural history of infection associated with cervical carcinoma in order to determine the role of viral and immune factors associated with cervical dysplasia progression PhD or Post Graduate Specialization; previous experience in the field of microbiology 8/B 9/B 10/B 11/B Prof. Mario Strazzabosco Prof. Ildebrando Marco Appollonio Prof. Carlo Ferrarese Medical sciences Medical sciences-Medicine MED/12 The project will test the hypothesis that innate immune pathways play a role in the reaction of the biliary epithelium to damage and alteration of these pathways represent the primary pathogenetic event in inflammatory sclerosing cholangitis Experience on the main cellular and molecular biology techniques and in isolation and colture of human and murine cholangiocytes are required Medical sciences The study protocol includes an extensive Parieto-temporal dementias: a neuropsychological assessment of patients, the data-driven analysis of analysis of FDG-PET scans using statistical Neurosciences-Neurology MED/26 cognitive and neuroimaging parametric mapping, a principal factor analysis of parameters data to test empirically for the existence of discrete syndromes The ideal candidate is a doctor or psychologist with an expertise in cognitive assessment and general knowledge of neuroimaging analysis Vascular impairment in Alzheimer's disease: implication for the emerging disease modifying therapies The research concerns the translational study of Biomedical degree the pathogenetic mechanisms of cerebrovascular (MD,biologist,biotechnologist,pharmac damage and neurodegeneration in Alzheimer's eutical chemist) with experience on disease, focusing on the recently emerged antitranslational studies in Amyloid disease modifying therapies neurodegenerative disorders Efficacy of a relational approach to the treatment of MED/39 children with severe developmental disorders Degree and specialization in Study of the clinical evolution of children with developmental psychology. Experience severe developmental disorders in relational approach treatments: assessment of the on developmental disorders and effectiveness through the Children’s Play Therapy knowledge of CPT instrument and Instrument statistics Feasibility study on Medical sciences-Medicine MED/40 mesenchimal stem cells use in genital prolapse surgery Genital prolapse has high prevalence and 29% Knowledge of phisiopathology and risk of surgical failure. Objective of this study is to clinics of genital prolapse. Experience evaluate both in vitro and in vivo on mouse the in animal sperimentation. Skills in stem employment of stem cells in pelvic reconstructive cell biotechnology surgery to reduce relapse risk NeurosciencesNeurobiology Medical sciences Dott.ssa Renata Nacinovich Medical sciences 12/B Prof. Rodolfo Milani Medical sciences Role of biliary epithelium innate immunity in inflammatory sclerosing cholangitis Medical sciences-Other MED/26 Evaluation Committee: Prof. Giovanni Tredici Prof.ssa Francesca Neri Prof.ssa Leda Dalprà Prof.ssa Marialuisa Lavitrano Prof.ssa Patrizia Vergani Dott.ssa Valeria Isella Preselection result: within November 20, 2013 Interview: date hours where november 28, 2013 14.30 Dipartimento di Chirurgia e Medicina Interdisciplinare, U8, Via Cadore n. 48, Monza, piano 4, aula riunioni