Download Spring 2014 Chem 100 Organic Synthesis and Mechanism

Spring 2014
Chem 100 Organic Synthesis and Mechanism
I t t Prof.
Instructor:
P f Meng-Lin
M
Li Tsao
T
(曹夢麟)
Office: SE 360
Tel:
228-4511
Email: [email protected]
Lectures: T, R 9:00 am – 10:15 am, COB 120
Office hours: MW 10:30am – 11:30 am
and by appointments
Spring 2014
Chem 100 Organic Synthesis and Mechanism
TA Shuhuai
TA:
Sh h i Xi
Xiang (([email protected])
i
@
d d )
Dustyy Ventura (([email protected])
@
)
Al Tramontano ([email protected])
Office hours: TBA
Textbook: P. N. Bruice, Organic Chemistry,
Prentice Hall, 6th ed., 2011
Recommended:
Bruice Study Guide and Solution
Solution’s
s Manual
Organic Chemistry Molecular Models Kit
• Course Goals/Objectives
This course is designed to help students build a solid
knowledge base of common methods and applications in
organic synthesis. Reaction mechanisms are emphasized
g chemical reactivity
y and p
predicting
g
for understanding
reaction outcomes.
You are expected to read each assigned chapter in Bruice
before the class period in which that chapter is discussed.
A successful Chem 100 student will prepare by reading
the book, attend lectures, ask questions, and do many
practice problems.
Homework:
H
k You
Y are encouraged
d tto d
do problems
bl
iin th
the
textbook. Problem sets will be posted on CROPS each
Thursdayy afternoon and will be collected during
g the
subsequent class.
Exams:
Quizzes (chances for extra credits)
3 Midt
Midterm exams (F
(Feb
b 20
20, M
Mar 20
20, A
Apr 24)
Final exam (May 13; comprehensive)
Grading:
Homeworks: (all 14)
Midterms: ((3 x 100 )
Final Exam:
Total:
100 points
300 points
p
200 points
600 points
A = 90%; B = 80%; C = 70%; D = 60%; F = 0-59%
A curve may be applied to course grades.
Misc items on syllabus:
• UCM CROPS: Resources
Announcements
Gradebook
• Cl
Class P
Policies
li i
Attendance and behavior
• Academic
A d i Integrity
I t
it Policy
P li
• Disabilities Services Information
Chem 100 Lecture Schedule (Tentative) – Spring 2014
Date
T 1/21
….
….
R 2/20
….
….
R 3/20
….
….
….
R 4/24
….
….
T 5/13
Topic Covered
Syllabus; Carbonyl compds 17.1-2
17 1 2
Aldehyde & Ketones 18.1-18.10,18.14
Enolate 19.1-19.3
1st Midterm Exam (Ch 17 & 18 )
Alkyne 6.1-6.8
Radicals 12.1-12.9
2nd Midterm Exam ((Ch 19,, 6 & 12 )
Redox 20.1-20.4
Amines&heterocycles 21.1-21.7
Carbohydrates 22.1-22.6
3rd Midterm Exam (Ch 20, 21 & 22 )
Amino acids 23.1-23.3
Nucleic Acids 28.1-28.4; course evaluation
Fi l Exam
Final
E
(comprehensive)
(
h i )
Organic Chemistry
6th Edition
Paula Yurkanis Bruice
Chapter 17
Carbonyl Compounds I
Reactions
eact o s o
of
Carboxylic Acids and
Carboxylic Acid
Derivatives
9
Class II carbonyl compounds:
will be discussed in Ch. 18
Class I carbonyl compounds:
How to name a carbonyl compound?
O
O
OH
propane
propanoic acid
O
propanoic anhydride
O
O
O
O
Cl
H
propanal
propanoyl chloride
O
O
NH2
propanamide
N
O
propanone
methyl propanoate
propanenitrile
How to name a carbonyl compound?
O
Cl
cyclohexanecarbonyl chloride
cyclohexane
O
O
OH
NH2
cyclohexanecarboxylic acid
cyclohexanecarboxamide
O
N
O
methyl cyclohexanecarboxylate
cyclohexanecarbonitrile
How to name a carbonyl compound?
O
Cl
benzene
benzenecarbonyl chloride
benzoyl chloride
O
O
OH
NH2
benzenecarboxylic acid
benzoic acid
benzenecarboxamide
benzamide
O
N
O
methyl benzenecarboxylate
methyl benzoate
benzenecarbonitrile
benzonitrile