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RENAL WEBINAR Tom Cameron, DVM 8/20/14 Urinary System Kidneys Ureters Urinary bladder Urethra Smooth muscle Epithelial linings Nerve innervation Circulation Endocrine Complementary organs/tissues Nerve innervation Circulation Endocrine Complementary organs and tissues Liver Heart Adrenals Thyroid Digestive tract Bone marrow Urinary System Functions Kidneys Renal Disease Significant clinical symptoms don’t generally occur until the % of nephrons functioning drops to at least 30% (likely lower) Canine/Feline Renal Support Indications: Patients in need of renal support as indicated by BUN, creatinine, phosphorus, and urine specific gravity values Age-related renal changes Renal injury/toxic insult Hepatic patients in need of additional hepatic support Chronic inflammation o Cystitis o FLUTD o Crystalluria/Urolith formation o FUS Systems Supported: Kidneys Liver Vasculature Bone Marrow Heart Thyroid Autonomic nervous system Clinical goals: Goal is to normalize all aspects of urinary function In most cases, supplements can be given alongside conventional medications All conditions exhibiting renal compromise may need long-term support Caution in compromised animals Kidney – one of the primary excretion routes Can see detoxification reactions Start conservatively, especially in older or very compromised animals Early intervention has the best prognosis Ingredients: Bone meal – ca, p, connective tissue support, intrinsic factors of bone marrow Spleen – SOD, rich iron source, reticuloendothelial system, antioxidant, immune system support Duodenum – supports nutrient absorption by supplying digestive intrinsic factors specific to the SI/duodenum Buckwheat – rich source of bioflavonoids, quercetin, Vit C and trace minerals, impt. For vascular integrity Indian gooseberry - rich source of bioflavonoids and Vit C Pea vine juice –– rich source of whole vit E complex. Benefits seen with high blood pressure, heart worm disease, high blood cholesterol and triglycerides or other heart ailments. Increased dietary polyunsaturated fatty acids increase the need for vitamin E. RNA – Opens capillary beds, supports improved microcirculation, supports cell reproduction, thyroid function Silybum marianum – contains flavanolignans (collectively known as silymarin) which are some of the most potent liver-protecting substances known. Stabilizes liver cell membrane against injury, assists in cellular regeneration, supports liver detoxification processes. Alfalfa juice – trace minerals, vitamins, and amino acids Kidney bean extract – supports arginase fxn in kidney – helpful in renal congestion (arginine buildup – from protein metabolism) Mushroom – rich source of vitamin C complex, for connective tissue health, vascular integrity, antioxidant, healing/regeneration Beet leaf juice – betaine HCl – lipotrophic agent impt for liver/gall bladder health, - Beets are loaded with A, B1, B2, B6 and C. They are also an excellent source of calcium, magnesium, copper, phosphorus, sodium and iron. Carrot powder – vitamin A complex source, beta-carotene, trace minerals, carotenoids Clinical Protocols: o Cystitis o Canine/Feline Renal Support/Renafood (4/3/2) o Canine/Feline Immune Support/Immuplex (3/2/1) o Crystalluria/Urolith formation o Canine/Feline Renal Support/Renafood (4/3/2) o Canine/Feline Immune Support/Immuplex (3/2/1) o Crystal Stone Formula (www.tcvmherbal.com) o Renal Insufficiency o Canine/Feline Renal Support/Renafood (4/3/2) o Renatrophin PMG (4/3/2) o Canine/Feline Hepatic Support/Livaplex (3/2/1) o Detoxification o Canine/Feline Renal Support/Renafood (4/3/2) o Canine/Feline Hepatic Support/Livaplex (3/2/1) SP Human Products: Arginex uses: “gum-out” for kidneys need shown by: cells, casts, albuminuria in UA. Decreased SG, failure to concentrate, body odor, liver disease, enlargement, decreased urination, Contains arginase, impt for metabolizing urea for excretion. Elimination of toxins and influencing the osmotic transfer of tissue fluids (edema). Liver and kidney support Add to any liver case Dosage: 4/3/2 Albaplex – for worst kidney cases (cancer), cystitis, renal/liver support. Contains: o Kidney bean extract o Betacol – liver o Renatrophin PMG o Renafood o Choline – lipotrophic o Cataplex AC – healing o Arginex o Thymex Dosage: 3/2/1 Renatrophin PMG – for any urinary problem Fluid balance (also tx adrenals) BP changes Toxemia Anemia (seen in chronic nephritis) Dosage: 4/3/2 Renafood – (Renatrophin PMG + Arginex) Renal hypertension Edema General renal support Renal protein overload Contains: o Arginex – decongest, detoxify, ‘gum out’ for the kidneys o Cataplex ACP – healing o Chlorophyll – detox/healing o Betacol – liver o Cataplex G – b vitamin effects on cell proliferation o Cataplex F – EFA to enhance calcium utilization Dosage: 4/3/2 AC Carbamide Works well with Arginex Osmotic diuretic Helps detox a sluggish liver by flushing the route of elimination through the kidneys Of greatest value in toxic cases where body is holding excess water ‘The solution to pollution is dilution.’ Indications: Kidney-bladder symptoms – natural diuretic Water balance Sweat gland activity (unexplained) Acidosis Gastritis – ulcers, epithelial lining problems Allergic reactions – bee stings, asthma o Due to kidney backup and hyperalkalinity o Add Cal-Amo Local applications – poultice for weeping lesions Glaucoma Urinary burning o Arginex o AC Carbamide