Download Serenin Vet - Animal Necessity

330 West 38th Street
Suite # 801
New York, New York 10018
Phone: 1-800-721-1310
Email: [email protected]
Serenin Vet
TM
Anti-anxiety Support
Behavior problems are common in captive marine animals. Most are due to stress, anxiety, fear
and/or frustration, and can result in stereotypic, aggressive and fearful behaviors. Serenin Vet’s
unique combination of natural vitamins and extracts, including Vitamin B-6, Vitamin B-12 and
St. John’s Wort may help reduce anxiety and inappropriate behaviors.
Ingredients (serving size 2 capsules)
Vitamin B-6
Folate
Vitamin B-12
Magnesium
Selenium
Griffonia simplicifolia 5-HTP (L-5-hydroxy-tryptophan)
D-L Phenylalanine
Eleuthero powder (Eleutherococcus senticosus) (rhizome)
Inositol
L-Tyrosine
Passion Flower Extract (Passiflora Incarnata)
St. John’s Wort extract (Hypericum perforatum)
25 mg
400mcg
200mcg
100mg
70mcg
25mg
40mg
70mg
100mg
10mg
50mg
800mg
Griffonia simplicifolia 5-HTP (L-5-hydroxy-tryptophan)
Griffonia seed has been shown in human medicine to relieve signs of migraines, depression,
insomnia and anxiety. It has also been used to ease chronic pain of fibromyalgia, including
morning stiffness, shoulder, neck and spine pain and chronic headaches. Griffonia is a natural
source of 5HTP (5-Hydroxytryptophan), an enhancing amino acid that is a highly absorbable
type of tryptophan. 5-HTP has been suggested as a treatment for many conditions, such as stress,
anxiety, panic attacks, and pain. It is also the direct precursor to serotonin, a neurotransmitter
that exerts a calming effect and regulates sleep. The active constituents are 5-hydroxytryptophan
(5-HTP) and lectin I-b4.
5-HTP may cause gastrointestinal disturbances, mood disturbances, seizures, or abnormal blood
counts. 5-HTP has also been associated with increased blood cortisol levels and increased risk of
suicide in individuals with psychiatric illnesses in human medicine. It is likely unsafe to use 5HTP in individuals using CNS depressants, antihypertensives, decarboxylase inhibitors,
antidepressant medications (TCAs, MAOIs, SSRIs, nefazodone, trazodone, venlafaxine,
mirtazapine, bupropion) or any other medications that may affect serotonin and in patients with
bradycardia, seizure and mental disorders, eosinophilia syndromes or mitochondrial
encephalomyopathy, pregnant and lactating females and in patients with a known allergy to 5HTP-containing products.
DL-Phenylalanine
This is a combination of the D - and L - form of the amino acid Phenylalanine. This form of
phenylalanine acts as a natural pain reliever. DL- Phenylalanine blocks the enzymes responsible
for the breakdown of endorphins and enkephlins. Endorphins and enkephlins are a group of
substances within the body that helps relieve pain. Experiencing pain is directly related with the
experience of anxiety in human and veterinary medicine. Many Fibromyalgia and chronic pain
human patients have benefited from taking DL-Phenylalanine.
Eleuthero powder (Eleutherococcus senticosus) (rhizome)
Eleutherococcu possesses a variety of medicinal properties, such as: increased endurance,
immunogenic, memory improvement, anti-inflammatory, chemoprotective, and radiological
protection. Taken regularly, it enhances immune function, reduces cortisol levels and
inflammatory response, and it promotes improved cognitive and physical performance. In human
studies Eleuthero has been successfully used to treat bone marrow suppression caused by
chemotherapy or radiation, angina, hypercholesterolemia, and neurasthenia with headache,
insomnia, and poor appetite.
Inositol
Commonly referred to as Vitamin B 8, studies have shown benefits of inositol for human patients
with depression, panic disorders and diabetes. Naturally, it is most prevalent in the heart and
brain. It affects nerve transmission and helps the body to transport fats. While no specific
deficiencies have been found in relation to diseases, some people may benefit from
supplementation.
L-Tyrosine
Tyrosine is a nonessential amino acid that is the precursor of some of the neurotransmitters
associated with regulating mood. Deficiencies in tyrosine, therefore, have been associated with
depression. Tyrosine also aids in the production of melanin (pigment responsible for hair and
skin color) and in the function of organs in the body responsible for making and regulating
hormones, including the adrenal, thryroid, and pituitary glands.
Passion Flower Extract (Passiflora Incarnata)
The flavonoids in passion flower are the primary constituents responsible for its relaxing and
anti-anxiety effects. The European literature involving passion flower recommends it primarily
for anti-anxiety treatment; in this context, it is often combined with valerian, lemon balm, and
other herbs with sedative properties. Passiflora has a depressant effect on Central Nervous
System activity and is hypotensive. It is been used for its sedative and soothing properties, to
lower blood pressure, prevent tachycardia and for insomnia. It can also be effective in relieving
nerve pain.
St. John’s Wort
St. John's Wort has been used for centuries to treat mental disorders and nerve pain. St. John's
Wort has also been used as a sedative and a treatment for malaria, as well as a balm for wounds,
burns, and insect bites. Today, the most common use of St. John's Wort in human medicine is in
the treatment of depression, anxiety, and sleep disorders. Supporting research in studies on the
treatment of depression have reported St. John's Wort to be more effective than placebo and
equally effective as tricyclic antidepressants and selective serotonin reuptake inhibitors in the
short-term management of mild-to-moderate depression.
While generally well-tolerated in clinical use, there are significant drug interactions with St.
John's Wort, particularly when used with medications metabolized by the cytochrome P450
system. St. John's Wort is not recommended for patients taking protease inhibitors or nonnucleoside reverse transcriptase inhibitors, receiving immunosuppressive therapy (particularly
cyclosporine), and in users of oral contraceptives, warfarin, or digoxin. St. John's Wort may
cause nausea and other gastrointestinal symptoms, dry mouth, dizziness, fatigue, headache,
anxiety, allergic reactions, impotence, and photosensitivity. St. John's Wort may induce mania in
individuals with an underlying mood disorder, and may result in serotonin syndrome if used
alone or with other serotonergic agents. St. John’s Wort is possibly unsafe when used in larger
than recommended doses, or for extended duration (>3 months); when used with drugs
metabolized by cytochrome P450 3A4 and 2E1, as decreased drug levels may occur; in patients
with diabetes or in those taking antidiabetic agents, in renal transplant patients due to potential to
cause overdosage or fatal drug-herb interactions, in females on oral contraceptives, in patients
with sensitive skin or those taking photosensitizing drugs, in patients with bleeding disorders or
in those taking anticoagulants, when used by individuals going through surgery due to difficulty
inducing relaxation and anesthesia, in patients taking digoxin due to reports of reduced efficacy
or drug concentration, in patients using chemotherapeutic agents as concomitant use may result
in reduced effectiveness of chemotherapeutic agents and treatment failure, and in patients on
monoamine oxidase inhibitors (MAOIs), selective serotonin reuptake inhibitors (SSRIs) or other
serotoninergic drugs.
Side Effects and drug interactions
Some of the components on Serenin might interact with various medications as reported in the
human and veterinary medicine. No safety studies have been done and Serenin is not FDA
approved. Do not use Serenin if your pet is on a monoamine oxidase inhibitor (MAOI), on an
antidepressant or any other serotoninergic drugs. Drug interactions can also happen with
cyclosporine, digoxin, indinavir (and possibly other imunosupressive drugs), irinotecan (and
possibly other drugs used to treat cancer), warfarin and related anticoagulants, and tramadol.
This list is not exhaustive. Please consult with your veterinarian before using Serenin if the
animal is on other dietary supplements or medications.
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