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Biochemical Society Annual Symposium No. 76
contents
C 2009 Honorary Editor: David J. Richardson Volume 37 Part 3 June 2009 www.biochemsoctrans.org
London: The Biochemical Society DNA Damage: from Causes to Cures
Robinson College, Cambridge, U.K., 15–17 December 2008
Edited by Richard Bowater (University of East Anglia, U.K.), Rhona Borts (Leicester, U.K.) and Malcolm White
(St. Andrews, U.K.).
DNA Damage: from Causes to Cures
Richard P. Bowater, Rhona H. Borts and Malcolm F. White
479–481
GlaxoSmithKline Award Lecture
The DNA-damage response: new molecular insights and new approaches to
cancer therapy
Stephen P. Jackson
483–494
Colworth Medal Lecture
Control of genome stability by Slx protein complexes
John Rouse
495–510
Sir Frederick Gowland Hopkins Memorial Lecture
Functions of p53 in metabolism and invasion
Karen H. Vousden
511–517
Novartis Medal Lecture
The search for a human Holliday junction resolvase
Stephen C. West
519–526
C 2009 Biochemical Society
Volume 37 Part 3 i
contents
The associations of sequence variants in DNA-repair and cell-cycle genes with
cancer risk: genotype–phenotype correlations
Janet Hall, Virginie Marcel, Celeste Bolin, Marie Fernet, Laurence Tartier, Laurence Vaslin
and Pierre Hainaut
527–533
Biochemical properties of mammalian TREX1 and its association with DNA
replication and inherited inflammatory disease
Tomas Lindahl, Deborah E. Barnes, Yun-Gui Yang and Peter Robins
535–538
Repairing DNA double-strand breaks by the prokaryotic non-homologous
end-joining pathway
Nigel C. Brissett and Aidan J. Doherty
539–545
Structure, function and evolution of the XPD family of iron–sulfur-containing
5 → 3 DNA helicases
Malcolm F. White
547–551
Genomic instability and cancer: lessons from analysis of Bloom’s syndrome
Miranda Payne and Ian D. Hickson
553–559
Regulation of activation-induced cytidine deaminase DNA deamination activity in
B-cells by Ser38 phosphorylation
Uttiya Basu, Andrew Franklin, Bjoern Schwer, Hwei-Ling Cheng, Jayanta Chaudhuri and
Frederick W. Alt
561–568
The impact of heterochromatin on DSB repair
Aaron A. Goodarzi, Angela T. Noon and Penny A. Jeggo
569–576
Short-patch single-strand break repair in ataxia oculomotor apraxia-1
John J. Reynolds, Sherif F. El-Khamisy and Keith W. Caldecott
577–581
A molecular model for drug binding to tandem repeats of telomeric
G-quadruplexes
Shozeb M. Haider and Stephen Neidle
583–588
The role of recombination in telomere length maintenance
Nicola J. Royle, Aarón Méndez-Bermúdez, Athanasia Gravani, Clara Novo, Jenny Foxon,
Jonathan Williams, Victoria Cotton and Alberto Hidalgo
589–595
Understanding the functions of BRCA1 in the DNA-damage response
Maximina H. Yun and Kevin Hiom
597–604
PCNA on the crossroad of cancer
Ivaylo Stoimenov and Thomas Helleday
ii
C 2009 Biochemical Society
Volume 37 Part 3 605–613