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PASMODIN DROPS/SUSPENSION
Generic name:
Category:
Composition:
Dicyclomine+Simethicone
Antispasmodic/ Anti-cholinergic
Pasmodin Suspension
Each 5ml contains
Dicyclomine HCL USP……………10mg
Simethicone USP……..…………....40mg
Pasmodin Drops
Available in 50ml pack
Each ml contains
Dicyclomine HCL USP…………….10mg
Simethicone USP…………………...40mg
Available in 15ml pack
MECHANISM OF ACTION
Dicyclomine relieves smooth muscle spam of gastrointestinal tract via a dual mechanism:
Has direct smooth muscle relaxant action in addition to weak anti-cholinergic actions. As a
result tone and amplitude of contractions of stomach and intestine are reduced…spam may be
relieved.
Simethicone is used to relieve painful pressure caused by excess gas in the stomach and
intestines..esp in breast feeding babies where they inhale air along with the milk.
Simethicone allows gas bubbles in the stomach and intestines to come together more easily,
which allows for easier passage of gas.
INDICATIONS
 Irritable bowel syndrome: Generally affects the large intestine and is characterized by
cramping, bloating, gas, diarrhea and constipation.
 Flatulence: A state of Excessive gas in an alimentary canal.
 Intestinal spasm and cramps: Painful sensation caused by muscle contraction.
PHARMACOKINETICS
Absorption:
Rapidly absorbed, Tmax: 60-90 mins (oral)
Distribution:
Volume of distribution: approx 3.65L/kg
Excretion:
79.5% excreted in the urine and 8.4% in faeces.
Half-life:
Approx 1.8 hrs.
DOSAGE AND ADMINISTRATION
 Infant(6months-1year): 0.5 ml orally 3-4 times daily
 Children(1- 11/2 year): 1ml-5ml orally 3-4 times daily.
 Children( 11/2-12 years): 10ml 3-4 times a day
All doses are administered 15minutes before feed.
CONTRAINDICATIONS
• Contraindicated for child under 6 months.
• Antimuscarinics are contra-indicated in myasthenia gravis paralytic ileus, pyloric
stenosis, and toxic megacolon.
•
SIDE EFFECTS
Side-effects that occur occasionally include nausea, vomiting, and giddiness; very rarely, angle
closure glaucoma may occur.
Other muscarinic side effects (marked much less):
constipation, transient bradycardia (followed by tachycardia, palpitation and arrhythmias),
reduced bronchial secretions, urinary urgency and retention, dilatation of the pupils with loss of
accommodation, photophobia, dry mouth, flushing and dryness of the skin