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• • • • • • • • • • • Probiotics and Nutraceuticals Microbial genetics Antimicrobial chemotherapy Molecular virology, Recombinant DNA technology Structural Biology and Protein Chemistry DNA-interacting Molecules Enzyme Inhibitors Structure Function of Proteins Nucleosides as Antivirals Biomimetic Chemistry of Metals Computer Simulations of Biomolecules • • • • • • • • • Bio Hydrogen Lab Bio Process Lab Biochemical & DSP Lab Cell & Molecular Biology Lab Micro & Immunotech Lab Plant Biotech Lab Computation Lab Medical Biotechnology Lab Fermentation Technology Lab • • • • • • • • • • • Air-lift bioreactor Atomic absorption spectrophotometer Centrifugal evaporator Darkroom/Cold room / Radio-isotope facilities DNA finger printing ELISA reader Fermentation Technology Gas Chromatograph High speed refrigerated cooling centrifuge Liquid nitrogen storage facility Milli-Q water purifier • • • • • • • • • • Netzs Thermal Analyzer (DSC, TGA, DTA) Perkin Elmer FT IR Spectrometers Perkin Elmer CHN Analyzer Digital Polarimeter (JASCO) Fluorimeter CH Electrochemical Analyzer Thermal Analyser UV & Visible Spectrophotometer Bruker AC 200 MHz NMR Spectrometer Cyclic Voltammeter Model P9001 1) 2) 3) 4) 5) 6) 7) Magnetic Nano-Particle for Cancer Diagnostics Extraction of Chemical from Marine Bacteria for Chemotherapy Anti-Diabetic Drug from a Probiotic Bacterium Bench-Scale Technology for Manufacture of ProBiotics Non Invasive Sterile Drug and Device Manufacturing System Extraction of Polyphenols from Green Tea Leaves Smart-Reversible Inhibition of Sperm Under Guidance • • • • • • Technology development & transfer for selected medicinal plants: approach through R&D and ex-situ cultivation Biosynthetic silk hydrogel extracellular matrix analogues for mammalian cell support and drug delivery Studies on the immunomodulatory properties of Aloe vera gel and its products Exploring the immunomodulatory potential of mushroom glucan/proteoglucan as Biological response modifier in cancer therapy Enantiomeric separation of chiral drugs by micellar electrokinetic capillary chromatography A rational approach towards anticancer drugs and chemosensors • Herbal/ bioproduct development • Water pipe fermented tobacco products • Biocatalyst based continuous production of biodiesel • • The UC Berkeley – IIT Kharagpur collaboration focused on biofuels (energy), and biotech (healthcare) Indo-Norwegian- Institute collaboration on Characterization of two histidine kinases and their cognate response regulator Research Hub Strong intellectual capital Produces unparalleled technically competent students Healthy balance of core and non core engineering courses Emphasis on hands on, learn as you do approach Numerous successfully completed projects FEATURES •Magnetic nano-particle coated with folic acid •After injection to patient the particle is absorbed selectively by cancer cell and the lesion is easily identified by Magnetic Resonance Imaging USP • • • • Low cost high efficiency for detection better than the conventional X-ray technique Perfectly harmless to the body FEATURES • Biosurfactants isolated from a marine bacterium are found to have significant antimicrobial activity and can be used in chemotherapy. USP •Non-hemolytic in nature •Does not harm normal cell lines due to low concentration •Shows properties such as metal binding, emulsification FEATURES •An exo- polysaccharide with potential anti-diabetic activity •Produced by simple fermentation and purification process •Characterized in terms of sugar monomers and its ability to reduce blood glucose levels in an animal model. USP • • • • • First anti-hyperglycemic exopolysaccharide molecule from a pro-biotic GRAS(Generally Regarded As Safe) by US FDA Potential drug candidate for both type 1 and type 2 diabetes. far better results in comparison with standard drugs for type 2 diabetes Biodegradable, non- toxic and has no side effects FEATURES •Manufacturing endospores of a pro-biotic bacterium at a lab scale •Can lead to development of some neutrateuticals •Maximum of 6 x 1012 spores/gm have been obtained •The process is optimized and stabilized in a 10 l reactor USP • • • • Confirms to all the characteristics of a GRAS organism (US FDA) Produced endospores can be stored under nonrefrigirative condition Very high potency and L(+) Lactic acid levels Proven to produce bacteriocin like antimicrobial substances, antioxidant exopolysaccharides FEATURES •Sterile drug or a device manufacturing system with controlled and enclosed microenvironment •All manipulations are performed by magnetic coupling across the enclosure and mini-robots placed within, controlled by electromagnetic coupling •No invasion of operating personnel; gloves; control cords into the manufacturing space USP • • • • Cost effective (70% less than conventional clean room facility) Minimal manufacturing zone is maintained at the best ‘Clean’ conditions No requirement of electricity or human operator Less particle contamination and transparency maintained by glass or polymeric sheet FEATURES •Centrifugation of tea juice, followed by special membrane based filtration process and drying of concentrated liquor to produce 60-70% pure polyphenol powder •Based on water extraction - without addition of any chemicals USP • “Green Process“absolutely safe for human consumption FEATURES •Non-hormonal male injectable contraceptive in the form of a clear gel •Within an hour after injecting into the vas deferens, produces an electrical charge to nullify electrical charge of spermatozoa USP • • • • • Composition is made to be effective for more than 10 years (long lasting) Safe with almost no side effects Antimicrobial Non-surgical Cost effective
