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PRODUCT SPECIFICATIONS CONTROLLED SUBSTANCES CAS REGISTRY NO. 6211-15-0 Morphine Sulfate USP Powder FORMULA (C17H19NO3)2·H2SO4·5H2O ITEM CODE 1516 MOLECULAR WEIGHT 758.83 APPEARANCE Fine, white powder, may yellow slightly with age SOLUBILITY Clear, colorless to slightly yellow solution IDENTIFICATION (USP) (A) IR: Matches standard (B) Formaldehyde: Purple then to deep blue-violet (C) Ferric Chloride: Blue to dark red (D) Sulfate: Meets USP requirements SPECIFIC ROTATION (ANHYDROUS BASIS) (USP) -107o to -109.5o ACIDITY (USP) 0.50 mL Max WATER (EQUAL TO USP) 10.4 - 13.4% RESIDUE ON IGNITION (USP) 0.1% Max CHLORIDE (USP) No turbidity AMONIUM SALTS (USP) No ammonia odor LIMIT OF FOREIGN ALKALOIDS (USP) 7.5 mL Min ORGANIC VOLATILE IMPURITIES Meets USP requirements ASSAY (HPLC) (ANHYDROUS BASIS) (EQUAL TO USP) 98.0 - 102.0% w/w RELATED SUBSTANCES Codeine Sulfate: 0.20% area Max Pseudomorphine: 0.15% area Max Morphine N-Oxide: 0.15% area Max Normorphine: 0.15% area Max 10-Hydroxymorphine: 0.15% area Max Unknown rel. subs. (each): 0.10% area Max Total rel. subs.: 0.50% area Max PARTICLE SIZE d10: NMT 5 micron d50: NMT 10 micron d90: NMT 25 micron SIEVE TEST No. 100: 99% Min through ABSORBANCE (400 nm) 0.170 Max MORPHINE is a phenanthrene-derivative opiate alkaloid. It is the principal alkaloid of crude opium, which is a resinous prep of the opium poppy, Papaver Somniferum. It is present in opium at approximately 10%. Morphine Sulfate is the principal salt of morphine and a world-wide standard for pain treatment. Morphine Sulfate is a strong analgesic used to relieve severe, acute pain or severe, chronic pain (i.e., in terminally ill patients). The drug is also used parenterally for preoperative sedation, as a supplement to anesthesia, and for analgesia during labor. Morphine is used in patients with acute pulmonary edema for its cardiovascular effects and to allay anxiety. Morphine is the drug of choice in relieving pain of myocardial infarction. Common Trade Name: Roxanolâ„¢, MS Contin®, and Astramorph® RESIDUAL SOLVENTS (USP) Meets USP requirements DRIPAVINE (EP) 0.20% w/w Max MORPHINONE (EP) 0.15% w/w Max The information printed herein is derived from our own laboratories and other sources, and is believed to be accurate. However, it may be modified by later findings and should be used with this understanding. Nothing herein shall be construed as a recommendation to use any product in violation of any patent rights. The user shall have sole responsibility for determination of whether this product is suitable for any particular purpose. Prior to use, refer to the Material Safety Data Sheet for assistance in determining safe handling, storage, and use procedures. Effective 3/2014