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Anatomy Outline Test #3 Lec. 19,20: Muscles of Facial Mastication Facial Muscles Groups of Muscles Epicranial: wrinkle forehead, move eyebrows (frontoccipital m. ) Orbital: close eyelids o Obricularis oculi Orbital: orbits eye: elliptical arrangement of fascicles- circles eye Palpebral: covers eyelid Origin: medial margin of orbit Fxn: close the eyelids, lateralmedial direction (squeegie of tears) Ptosis: drooping of eyelid corneal ulcerations from lack of lacrimal fluid Nasal: dilate/flare nostrils Oral: change shape of mouth, posture of lips o Many muscles insert on modiolus o Modiolus: mobile fibromuscular mass, convergence of 9 muscles, integrating activities (dimple) o Buccinator Substance of cheek Origins: maxilla, mandible, pterygomandibular raphe Insertion: modiolus, orbicularis oris Fxn: keeps cheek taunt (smiling, expel air when speaking) Paralysis: food remains in oral cavity o Zygomaticus major Fxn: elevates labrial commissures (corners of lips) snear, smile o Orbicularis oris: 4 quadrants peripheral part, marginal part better control over mouth because of quadrants Crossing of fibers medially ridges of philtrum Fxn: squeeze lips together Paralysis: drooping of corner of mouth (food dribbles out) Innervation All muscles of facial expression innervated by facial nerve (motor) o Longest interosseus course of any CN o Exits sylomastoid foramen in skull parotid gland parotid plexus 5 branches (temporal, zygomatic, buccal, marginal, cervical branches) Trigeminal nerve (sensory) o V1: opthalamic nerve supraorbital nerve by supraorbital notch (test for sensory innervation) o V2: maxillary nerve infraorbital nerve at infraorbital foramen o V3: mandibular nerve mental nerve at mental foramen Sensory and motor of muscles of mastication Vasculature External carotid a. majority of face o facial a. (branches deep to mandible) angular a. (nose) and superior and inferior labial a. o superficial temporal a. (temporal pulse) transverse facial a. branch o Maxillary a. muscles of mastication, mandible, maxillay, nose, palate, dura mater Opthalamic a. Internal carotid artery (medial forehead) Veins: Triangular Danger zone: connections form facial veins to dural venous sinuses (valveless?) o Superior labial vein and angular vein cavernous sinus Lymphatic Drainiage: o Submandibular nodes: forehead and anterior part of face o Submental nodes: lower lip and chin o Pre-auricular and parotid nodes: lateral part of face Muscles of Mastication: act on TMJ joint: only movable joint of the head Temporal fossa: above zygomatic arch Infratemporal fossa: below zygomatic arch TMJ: synovial joint: articulation between head of mandible and mandibular fossa of temporal bone (on skull) o Fibrocartilage, weight bearing (opposite side of bite force) o Ligaments: Lateral (temporomandibular) ligament: prevents post. Dislocation of TMJ (intrinsic, part of joint capsule) Sphenomandibular and stylomandibular: extrinsic Lateral and sphenomandibular lig. Are “swinging hinges” for mandible o Divided by fibrous articular disc Superior articular cavity: attaches disc to temporal bone Loose capsule Gliding occurs here Inferior articular cavity: attaches disc to mandible Tight capsule Hinge and pivot motion occur here o Movements of TMJ Gliding, hinge, pivot mouth open 15 deg, only hinge action= depression of mandible (head of mandible remains in mandibular fossa) mouth open >15 deg, hinge action + gliding of mandibular head = depression and protraction of the mandible physiologically dislocate jaw mandibular head glides forward and inferior to articular tubercle o Grinding: one mandibular head rotates vertically (pivots) while the other swings/glides anteriorly = lateral motion Movement of the Mandible o Elevation/depression o Protraction/retraction aka protrusion/retrusion o Lateral excursion/medial excursion o Mouth open 15 d If TMJ dislocated, usually anteriorly, mouth depressed, person unable to close mouth, reduce by pressing on mandibular teeth Muscles of TMJ joint (all innervated by V3- sensory and motor) o Temporalalis: inserts on side of cranium, inserts on coronoid process Upward and backward pull o Masseter: mashing/pounding food between molars- elevation of mandible From zygomatic arch lateral surface of angle of mandible o Medial Pterygoids Deep head Superficial head Inserts on deep surface of ramus of mandible and lateral plate of pterygoid process (on sphenoid bone) Lateral movement of the jaw, some elevation o Lateral Pterygoids Upper head: inserts on TMJ capsule, articular disc Lower head: inserts on condylar process Mouth opening, chief protruder of mandible (opening mouth wide) Lec. 22 Cranial Osteology The Cranium Neurocranium: calvarium (domed roof) and skull base, direct ossification of mesenchyme Viscerocranium: from cartilaginous precurstors, and direct ossification of mesenchyme Norma Lateralis: pterion: area of skull where sphenoid, parietal, frontal, temporal bone meet thinnest part of skull, flexible can tear middle meningeal a. (even w/o a fracture) Cranial Fossae: 3 steps- anteriormiddle posterior fossae **remember 1,5,6) for the # cranial nerves in each fossa o Anterior fossa: cribiform plate: CN1 o Middle fossa (5): Optic canal: CN II and opthalamic a. Superior orbital fissure: CN III, IV, V1, VI (eye muscles and opthalamic branch of trigeminal nerve), opthlamic veins Blowout fx Foramen rotundum: CN V2 (maxillary branch) Foramen ovale: CN V3 (mandibular)- move your mandible open to make an “oval” with your mouth Foramen spinosum: middle menigneal a. Foramen lacerum: nothing of consequence o Posterior fossa Internal auditory(acoustic) meatus: CN VII, VIII, labyrinthine a. CN VII greater petrosal n. (mucosal secretion of nose-nose bleeds) Bells Palsy- CN VII Jugular foramen: CN IX, X, XI and superior jugular bulb (origin of internal jugular vein, and inferior petrosal sinus) CN XI exits here If no gag reflex (choking)- CN IX If shoulders depressed- CN XI bowel sounds- CN X Hypoglossal canal: CN XII (hypoglossal n.) Foramen magnum: SC, meninges, CSF, spinal a./v, vertebral a. , CN XI (goes into skull) The hyoid bone: no articulations with other bones!! * attached to the mandible, sternum, scapula, skull base via muscles o Lesser horn, greater horn o Speech, deglutition Lec. 23: Craniofacial Embryology Day 18: Prechordal plate + notochord induce overlying neuroepitheliumneural plateneural groove neural tube (cranial neuropore closes first) neural crest cells o Melanocytes o DRG o Sympathetic chain ganglia o Chromaffin cells of adrenal medulla o Pre-aortic ganglia o Enteric ganglia of PNS o Odontoblast (teeth) o CT of eye, papillary, ciliary m. o Truncocanal septum (separates aorta and pulmonary trunk) o Pharyngeal arch cartilage o Dermis/hypodermis of face/neck o Glial cells in peripheral ganglia, schwann cells, arachnoid, pia mater o *Albinism, Hirshprungs (no motor ganglia in GI tractconstipation, mega-colon) Base of skull 3 paired cartilages o Prechordal cartilage base of occipital bone o Hypohyseal cartilage around pituitary gland (sphenoid bone) o Parachordal cartilage 3 pairs of sensory capsules o otic capsules: develop around otic vesicles o nasal capsulesethmoid bone (nasal cavity) o optic capsules eye Calvaria forms by intramembranous ossification- dermal or membranous bones (temporal, maxillary, zygomatic bones) Cartilaginous viscerocranium 1st PA (Merkel’s cartilage): malleolus, incus, EAM o muscles of mastication, tensor tympani o terminal maxillary a. o mandible, maxillary prominences nd 2 PA: stapes, styloid process, hyoid bone (lesser horns, upper horn of hyoid) o stapedial a. (embryo)/corticotympanic a. (adult) o stapedius muscle o 2nd PA normally expands, fills in rest of the pharyngeal clefts/grooves if problemlateral cervical sinus (fluid filled cysts), fistulas (external/internal), “leaky baby” 3rd PA: lower rim, greater horns of hyoid, common carotid a., roof of internal carotid 4th PA: Laryngeal cartilage, arch of aorta, R. subclavian a. 6th PA: laryngeal cartilage, ductus arteriosus a. Face 5 swellings o Maxillary swellings (2) o Mandibular swellings (2) o Frontonasal Prominence (1) nasal placodesnasal pit medial and lateral nasal processes medial processes fuse medially intermaxillary process bridge of nose, philtrum, primary palate lateral process nostrils ectodermal nasal sac nasal fin (vacuolize) oronasal membrane (separates nasal, oral cavity) primitive choana (opening) Palate o Medial nasal processintermaxillary process primary palate o Maxillary processespalatine shelves (medial expansions of maxillary processes) proliferate, fuse in midline to each other, primary palate seals off primary choana leaves definitive choanae open o Incisive foramen: little hole where primary palate meets palantine shelves artery (hold for severe nose bleeds) Lec. 24: Ear Anatomy External Ear Auricle: concha (floor), helix (elevated margin), antihelix, Tragus, anti-tragus o Cervical plexus (lesser occipital C2, greater auricular C2,C3) – majority of back of ear o Vagus, glossopharyngeal n. (concha) o Trigeminal n. , auriculotemporal n. (front of ear/anterior, tragus) o Facial n. (random dots) EAM: tympanic part of temporal bone o Mandibular n. (V3), vagus n. *makes you cough when you stimulate o Cartilage 1/3 ceruminous, sebaceous glands o Bony medial 2/3 Vasculaization o Superficial temporal anterior auricular a. o Posterior auricular branches Lymphatic drainage o Anterior: parotid nodes deep cervical nodes o Posterior: Mastoid nodes deep cervical nodes o Lower: deep cervical nodes Tympanic Membrane o Gray-reddish tinge, cone of light at 5’o clock o Pars flaccida (less collagen), pars tensa (more collagen), malleolar stria: light colored streak o Outer surface innervated by auriculotemporal n., facial, vagus o Inner surface: glossopharyngeal n. (middle ear cavity) o Anterior tympanic a. (branch of maxillary a.) Middle Ear/Tympanic Cavity Petrous part of temporal bone Epitympanum (attic), Mesotympanum (medial to membrane), hypotympanum Roof = tegmental wall o Tegment tympani: small piece of bone o *unossified petrosquamous suture in kids possible spread of infection to cranial cavity Floor= jugular wall (separates it from internal jugular a. ) Lateral wall: tympanic membrane, bony wall of epithymapnic recess Medial Wall= labyrinthine wall o Separates from inner ear o Promontory prominence (cochleatympanic plexus) o Prominence of facial canal o Prominence of lateral semicircular canal o 2 openings: oval window (stapes), round window (cochlea) Posterior Wall=mastoid wall o Aditus to mastoid antrum (air cells) o Chorda tympani n. (CN VII branch) from prominence of facial canal *taste to ant. 2/3 tongue, motor for salivary glands Anterior Wall= carotid wall o Opening to pharyngotympanic/auditory tube (tensor tympani, exit for chorda tympanic n.) o Carotid canal Muscles o Tensor tympani: inserts on handle of malleoluscartilagionous part of auditory tube V3 branch o Stapedius: neck of stapes to posterior wall (tightens attachment to oval window) Nerve to stapedius Vasculature: mostly external carotid a. (branches), some internal carotid. Ossicles o First bones to ossify-mature at birth, mucous covering Inner Ear o Bony labyrinth (w/in otic capsule) o Cochlea, vestibule, semicircular canals o Membranous labyrinth o Vestibular labyrinth Utricle: 3 ampullae of semicircular ducts (crista ampularris) rotational movements of head Saccule: contains 2 maculae (head position, linear acceleration) o Cochlear labyrinth Cochlear duct (endolymph) spinal organ of corti, suspended by spiral ligament Scala vestibuli (upper), scala tympani (lower) perilymph o internal auditory a. (branch of AICA)- travels though IAC (w/ CN VII and VIII) Lec. 25: Ear Embryo o 4th-26 weeks o Mesenchyme: from mesoblast, neural crest cells o Placode= thickening of surface ectoderm Inner Ear Development o Finished my middle of fetal period o Requires induction of mesenchyme, hindbrain, notochord oral placodes (on hindbrain) invaginates otic pit o Statoacoustic ganglion vestibular cochlear ganglions o Otic vesicle membranous labyrinth (except melanocytes in stria vascularis of cochlea) Dorsal utricle utricle, semicircular canals (ampulla, cristae ampularris) Ventral saccule saccule, cochlear duct Cochlear ductinner and outer ridge of epithelial cells o Inner ridge spinal imbus (part of spinal lig) o Outer ridge 1 row of inner hair cells, 3-4 rows of outer hair cells o Membranous cochlea attached to saccule by ductus reuniens o Otic vesicle induces cartilaginous otic capsule vacuolization of perilymphatic space scala vestibuli, scala tympani (perilymph filled) o Cartilaginous otic capsule bony labyrinth (ossification of surrounding mesenchyme) Middle Ear Development o 1st PA endoderm o pharyngeal pouch contacts 1st pharyngeal groove 1st pharyngeal membrane=tympanic membrane o tubotympanic recess o tympanic cavity: envelopes ossicles, tendons, ligaments, nerves o pharyngotympanic tube o ossicles o Mastoid Antrum: mastoid cells don’t develop until 2 y/o External Ear Development o EAM: 1st pharyngeal groove/cleft (ectoderm) meatal plug (solid epithelial plate) central cells degenerate internal part of EAM o Tympanic membrane o Ectoderm o Endoderm o Mesoderm o Auricle: auricular hillocks on PA 1&2 o Fusion of auricular hillocks CN V (auricular temporal nerve from PA 1) Cervical plexus n. (PA 2) o **Expect chromosomal abnormalities w/ ear anomalies!!! Lec. 25: Eye and Orbit Eyelids (Palpebrae) skin subcutaneous tissue orbicularis oculi m- palpebtral part Tarsus and orbital septum o Tarsus: thickenings of orbital septum, strengthens eyelids, contains Meibomian glands that secrete oily substance o Orbital septum: thin membrane, spans orbital opening between margins of orbit and tarsi Palpebral conjunctiva Lacrimal Apparatus Lacrimal gland (has its own fossa) bactericidal nourishing fluid (because the cornea is avascular) Accessory ducts o Lacrimal glandexcretory ducts spreads across conjunctivalacrimal puncta (holes) lacrimal caniliculilacrimal sac (own fossa) nasolacrimal duct Innervation: sensory, sympathetic, parasympathetic Innervation of the eye: CN II: only sensory (though optic canal) CN IV, VI: only motor o CN IV: superior oblique o CN VI: lateral rectus o Enter via superior orbital fissure CN III, V, VII: motor and sensory o CN III: occulomotor Through superior orbital fissure Superior: superior rectus, levator palpebrae superioris Inferior: medial rectus, inferior rectus, inferior oblique Also carry parasympathetics to smooth muscle of ciliary body/iris o V2: Maxillary N. Infraorbital nerve (goes though infraorbital fissureinfraorbital canalinfraorbital foramensensory to face) o V1: opthlamic n. Superior orbital fissure 3 branches: Frontal n. – largest branch supraorbital and supratrochlear nerves (sensory to forehead) Lacrimal n. Nasociliary n. o Enters via common tendinous ring o ethmoid nerves (sensory to nasal cavity) o long ciliary nerves (sympathetics to dialator pupilae) Short ciliary n. (from ciliary ganglion): sensory/parasympathetic, sympathetic Extraocular muscles Fascial sheath: fascia of extraoccular muscles=periosteum of orbit 7 extraocular m. o o o o 4 rectus muscles 2 oblique muscles Levator palpebrae superioris: most superior muscle in orbit All muscles originate on common tendinous ring EXCEPT inferior oblique o All innervated by CN III EXCEPT CN IV: superior oblique, and CN VI: Lateral abducens Movements of eyeball o Vertical: abduction/adduction o Transverse: Elevation/Depression If gaze @ ocular axis: superior rectus elevates, inferior rectus depresses If gaze in vertical plane: inferior oblique elevates, superior oblique depresses o A/P: Lateral/medial o If at any other angle Superior rectus: MAddE “superior Maddy” – Medial rotation, adduction, elevation Inferior rectus: LAddD: inferior “lad” – Lat. Rotation, Adduction, depression Superior oblique: MAD: Medial rotation, abduction, depression “got MAD because they got abducted because they were oblique/not normal” Inferior Oblique: LAE: Lat. Rotation, Abduction, Elevation Blood supply o Internal carotid Opthalamic a. (through optic canal) supraorbital, supratrochlear, dorsal nasal a. face central a. of retina (in optic n) lacrimal a. ethmoid a. Venous Return o Superior and inferior opthlamic veinssuperior orbital fissurecavernous sinus Lec. 26: Development of the Eye Week 4 (Day 22)-Week 20 (not able to see well at birth) Eye development Comes from neuroectoderm (forebrain) = retina, optic n. o optic stalkoptic nerve o optic cup retina Mesenchyme = choroid, sclera Surface ectoderm of head= cornea, lens Optic grooves/sulci on side of forebrain (inside of neural folds) evaginates to form diverticulum optic vesicles (project into mesenchyme) optic stalk and optic cup (double walled) o Optic cup: outer, thinner layer pigmented layer of retina inner, thicker layer neural layer of retina (neuroepithelium) Lens Development Optic cup induces lens placode on surface ectoderm invaginates lens vesicles lies w/in optic cup 3 layers of lens o basil lamina of surface ectoderm lens capsule o anterior lens epithelium subcapsular epithelium (cuboidal) o posterior lens: Primary lens fibers (last lifetime) equatorial zone of lens secondary lens fibers (adds to external sides of primary lens fibers) Choroid Fissure Invagination in optic stalk and cup (on ventral surface) choroid/retinal/optic fissure (also contains vasculature for hyaloids a. ) Hyloid a. supplies blood to inner optic cup and lens vescile obliterates except for central a. of retina (since lens is avascular) Fissure fuses pupil and optic n. (as neural cells proliferate, obliterate lumen) Ciliary Body Stroma (muscle, CT)= from mesenchyme (edge of optic cup) 2 layered epithelium (continuous w/ 2 layers of retinal epithelium and iris) Outer layer of optic cup pigmented layer Inner layer of optic cup nonpigmented layer (neural retina) Iris Most anterior part of vascular coat Contractile diaphram pupil Highly vascularized CT stroma 2 layered pigmented epithelium (continuous w/ 2 layers of retina/ciliary body) stroma of iris: neural crest mesenchyme epithelium of iris inner and outer layers of optic cup Cornea sclera and cornea from mesenchyme (neural crest) 3 layers of cornea: o corneal epithelium (from surface ectoderm) o stroma (from mesenchyme) o corneal endothelium (neural crest cells) Eyeball Anterior segment: aqueous humor, circulating o Anterior and posterior chambers Posterior segment: vitreous body, filled w/ vitrous humor by age 4/5, stagnant Eyelids Mesenchyme 2 cutaneous folds of ectoderm lids adhere to each other, remain closed until 26-28 weeks