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TABLES DEPICTING SOME VARIATIONS OF THE CARCINOGENIC AND ANTI-CARCINOGENIC PROCESSES INVOLVING TWO OF MANY DIFFERENT KINDS OF INITIATING FACTORS THAT CAN BE FOUND IN THE CARCINOGENIC PROCESS Paula D. Gordon, Ph.D. http://GordonCancerTheory.com [email protected] August 25, 2015 Corrected Rendering The following two-sided tables illustrate the possible progression of the hypothetical stages and steps that can be involved in the carcinogenic process and the possible stages and steps that would need to be involved in the anti-carcinogenic process in order to counter the stages and steps in the carcinogenic process. Table of Contents: EXAMPLE 1: Showing Hypothetical Anti-Carcinogenic Stages Beginning on the Right Hand Side of the Table (Cancer Triggered by Initiating Environmental Toxins, Mutagens, Carcinogens, or Radiation) Pages 2-3 EXAMPLE 1’: Showing Carcinogenic Stages First Beginning on the Right Hand Side of the Table (A Reversed Version of the Carcinogenic Process)…………………………………………………………………….……Pages 4-6 Example 1A: (Variation of Example 1 with repeated stages) Showing Hypothetical Anti-Carcinogenic Stages Beginning on the Right Hand Side of the Table …………………………………………………………Pages 7-9 Example 1B: (Variation of Example 1’ with repeated stages) Showing Carcinogenic Stages Beginning on the Right Hand Side of the Table (A Reversed Version of the Anti-Carcinogenic Process) ………………………………………………………………………………………Pages 10-11 Example 2: Showing Hypothetical Anti-Carcinogenic Stages Beginning on the Right Hand Side of the Table (Cancer Triggered by a Genetic Predisposition) …………………………………………………………… Pages 13-14 Example 2’: Showing Carcinogenic Stages Beginning on the Right Hand Side of the Table (A Reversed Version of the Anti-Carcinogenic Process) …………………………………………………………………………Pages 15-17 1 EXAMPLE 1 Showing Anti-Carcinogenic Stages Beginning on the Right Hand Side of the Table Cancer Triggered by Initiating Environmental Toxins, Mutagens, Carcinogens, or Radiation) Example 1: Stage C1 of 5 Stages of Carcinogenesis of one example of how the Carcinogenic Process can unfold Subjection to environmental toxins, mutagens, carcinogens, radiation Stage AC1 of 5 Stages of Corresponding Steps needed to reverse the Carcinogenic Process Protection against environmental toxins, mutagens, carcinogens, radiation, include the use of anticarcinogenic regimen Rectification of dietary imbalances Poor diet, including poorly balanced diet with respect to vitamins, trace elements, amino acids and fatty acids Weak cellular integrity (including weakening brought about by bacterial, microbial, or viral attack), or cellular ground substance Shock, trauma, prolonged stress caused by grief, or stress cause by environmental factors Steps to strengthen cellular integrity of cellular ground substance Proactive measures to prevent shock or stress and to buffer effects when they occur, including periodic removal from environment when hazardous environmental factors persist Stage C2 Inadequate free radical scavengers Unwanted free radical reactions DNA damage Stage AC4 Assuring the adequacy of free radical scavengering Preventing or buffering against unwanted free radical reactions Protection against DNA damage or buffering of the effects Repair of DNA or managing of the consequences, including maintaining of fully functioning immune defenses Faulty DNA repair Stage C3 Respiration of affected cells toward fermentation Weakening or undermining of ground substances Impairment of capacity to get rid of affected cells owing to protective sheath surrounding tumor cells and overtaxing or absence of an adequate immune response, enzymatic activity, and detoxification capacity of body Stage AC3 Return to normal oxygen respiration Strengthening and maintenance of strong ground substance Enhancement of capacity to get rid of affected cells which can be stimulated by the use of proteolytic enzymes to help break down protective sheath surrounding tumor cells and by stimulating or otherwise enhancing the host’s immune response, enzymatic activity, and detoxification capacity Normalization of vascularization with attendant decrease in nutritional status of tumor cells Increasing vascularization of the tumor with attendant enhancement of nutritional status of tumor cells 2 Stage C4 Movement toward total breakdown of the immune response Movement toward serious of total impairment of detoxification capacity Cellular and systemic health degeneration Stage AC2 Priming and rebuilding of the immune response Enhancement of and rebuilding of host detoxification capacity Reversing process of cellular and systemic health degeneration Maintenance of positive mental and emotional health Degeneration of mental and emotional health Stage C5 Near total cellular and systemic health degeneration Stage AC1 Intensified efforts to reverse process of cellular and systemic health degeneration Intensified efforts to restore nutritional balance, including balance of body chemistry in general Intensified efforts to enhance and rebuild host detoxification capacity Intensified efforts to prime and rebuild the immune response Near total degeneration of nutritional status and near total imbalance of overall body chemistry Near total collapse of body’s detoxification capacity Near total collapse of the immune response 3 EXAMPLE 1’ Showing Carcinogenic Stages First Beginning on the Right Hand Side of the Table Example 1 Stage AC1 of an example of 5 Stages Involving AntiCarcinogenesis resulting in the reversal of the Carcinogenic Process Example 1 5 Stages of Carcinogenesis Stage C5 of an example of the Carcinogenic Process Intensified efforts to prime and rebuild the immune response Near total collapse of the immune response Intensified efforts to enhance and rebuild host detoxification capacity Near total collapse of body’s detoxification capacity Intensified efforts to restore nutritional balance, including balance of body chemistry in general Near total degeneration of nutritional status and near total imbalance of overall body chemistry Intensified efforts to reverse process of cellular and systemic health degeneration Near total cellular and systemic health degeneration Example 1 Stage AC2 Anti-carcinogenesis Reversing the process Example 1 Stage C4 Carcinogenesis Maintenance of positive mental and emotional health Degeneration of mental and emotional health Reversing process of cellular and systemic health degeneration Cellular and systemic health degeneration Enhancement of and rebuilding of host detoxification capacity Movement toward serious of total impairment of detoxification capacity Movement toward total breakdown of the immune response Priming and rebuilding of the immune response 4 Example 1 Stage AC3 Anti Carcinogenesis Reversing the process Example 1 Stage C3 Carcinogenesis Normalization of vascularization with attendant decrease in nutritional status of tumor cells Increasing vascularization of the tumor with attendant enhancement of nutritional status of tumor cells Enhancement of capacity to get rid of affected cells which can be stimulated by the use of proteolytic enzymes to help break down protective sheath surrounding tumor cells and by stimulating or otherwise enhancing the host’s immune response, enzymatic activity, and detoxification capacity Impairment of capacity to get rid of affected cells owing to protective sheath surrounding tumor cells and overtaxing or absence of an adequate immune response, enzymatic activity, and detoxification capacity of body Strengthening and maintenance of strong ground substance Weakening or undermining of ground substances Return to normal oxygen respiration Respiration of affected cells toward fermentation Example 1 Stage AC4 Anti Carcinogenesis Reversing the process Example 1 Stage C2 Carcinogenesis Repair of DNA or managing of the consequences, including maintaining of fully functioning immune defenses Faulty DNA repair Protection against DNA damage or buffering of the effects DNA damage Preventing or buffering against unwanted free radical reactions Unwanted free radical reactions Assuring the adequacy of free radical scavengering Inadequate free radical scavengers 5 Example 1 Stage AC5 Anti-Carcinogenesis Reversing the Carcinogenic Process Example 1: Stage C1 of 5 Stages of Carcinogenesis Proactive measures to prevent shock or stress and to buffer effects when they occur, including periodic removal from environment where hazardous factors persist Shock, trauma, prolonged stress caused by grief, or stress cause by environmental factors Steps to strengthen cellular integrity of cellular ground substance Weak cellular integrity (including weakening brought about by bacterial, microbial, or viral attack), or cellular ground substance Rectification of dietary imbalances Poor diet, including poorly balanced diet with respect to vitamins, trace elements, amino acids and fatty acids Protection against environmental toxins, mutagens, carcinogens, radiation, include the use of anticarcinogenic regimen Subjection to environmental toxins, mutagens, carcinogens, radiation 6 Example 1A (Variation of 1 with repeated stages) Showing Anti-Carcinogenic Stages Beginning on the Right Hand Side of the Table Variation 1A: Example 1: 6 Stages of Anti-Carcinogenesis Stage C 1 of a Variation of the Reversing the Process Stages that can be involved in Stage AC5 Carcinogenesis Stage C1 Subjection to environmental Protection against toxins, mutagens, carcinogens, environmental toxins, mutagens, radiation carcinogens, radiation, include the use of anticarcinogenic regimen Poor diet, including poorly Rectification of dietary balanced diet with respect to imbalances vitamins, trace elements, amino acids and fatty acids Weak cellular integrity Steps to strengthen cellular (including weakening brought integrity of cellular ground about by bacterial, microbial, substance or viral attack), or cellular ground substance Shock, trauma, prolonged Proactive measures to prevent stress caused by grief, or stress shock or stress and to buffer cause by environmental factors effects when they occur, including periodic removal from environment where hazardous environmental factors persist New Stage C2 What was formerly Stage C3 in Example 1 occurs now before what was formerly Stage C2 in Example 1 Respiration of affected cells toward fermentation Weakening or undermining of ground substances Impairment of capacity to get rid of affected cells owing to protective sheath surrounding tumor cells and overtaxing or absence of an adequate immune response, enzymatic activity, and detoxification capacity of body New Stage AC4 Formerly AC3 Return to normal oxygen respiration Strengthening and maintenance of strong ground substance Enhancement of capacity to get rid of affected cells which can be stimulated by the use of proteolytic enzymes to help break down protective sheath surrounding tumor cells and by stimulating or otherwise enhancing the host’s immune response, enzymatic activity, and detoxification capacity Normalization of vascularization with attendant decrease in nutritional status of tumor cells Increasing vascularization of the tumor with attendant enhancement of nutritional status of tumor cells 7 New Stage C3 What was formerly Stage C2 in Example 1 occurs now after what was formerly Stage C3 Inadequate free radical scavengers Unwanted free radical reactions DNA damage New AC3 Formerly AC4 Assuring the adequacy of free radical scavengering Preventing or buffering against unwanted free radical reactions Protection against DNA damage or buffering of the effects Repair of DNA or managing of the consequences, including maintaining of fully functioning immune defenses Faulty DNA repair Repeat of New Stage C2 What was formerly Stage C3 in Example 1 recurs and worsens Respiration of affected cells toward fermentation Weakening or undermining of ground substances Impairment of capacity to get rid of affected cells owing to protective sheath surrounding tumor cells and overtaxing or absence of an adequate immune response, enzymatic activity, and detoxification capacity of body Repeat of New AC4 Formerly AC3 Return to normal oxygen respiration Strengthening and maintenance of strong ground substance Enhancement of capacity to get rid of affected cells which can be stimulated by the use of proteolytic enzymes to help break down protective sheath surrounding tumor cells and by stimulating or otherwise enhancing the host’s immune response, enzymatic activity, and detoxification capacity Normalization of vascularization with attendant decrease in nutritional status of tumor cells Increasing vascularization of the tumor with attendant enhancement of nutritional status of tumor cells Stage C4 Movement toward total breakdown of the immune response Movement toward serious of total impairment of detoxification capacity Cellular and systemic health degeneration Stage AC2 Priming and rebuilding of the immune response Enhancement of and rebuilding of host detoxification capacity Reversing process of cellular and systemic health degeneration Maintenance of positive mental and emotional health Degeneration of mental and emotional health 8 Stage C5 Near total cellular and systemic health degeneration Stage AC1 Intensified efforts to reverse process of cellular and systemic health degeneration Intensified efforts to restore nutritional balance, including balance of body chemistry in general Intensified efforts to enhance and rebuild host detoxification capacity Intensified efforts to prime and rebuild the immune response Near total degeneration of nutritional status and near total imbalance of overall body chemistry Near total collapse of body’s detoxification capacity Near total collapse of the immune response 9 Example 1A’ (Variation of 1 with repeated stages) Showing Carcinogenic Stages Beginning on the Right Hand Side of the Table Variation 1A: Example 1 5 Stages of Anti-Carcinogenesis Stage AC1 Reversing the Carcinogenic Process 5 Stages of Carcinogenesis Stage C5 Intensified efforts to prime and rebuild the immune response Near total collapse of the immune response Intensified efforts to enhance and rebuild host detoxification capacity Near total collapse of body’s detoxification capacity Intensified efforts to restore nutritional balance, including balance of body chemistry in general Near total degeneration of nutritional status and near total imbalance of overall body chemistry Intensified efforts to reverse process of cellular and systemic health degeneration Near total cellular and systemic health degeneration Example 1 Stage AC2 Anti-carcinogenesis Reversing the process Stage C4 Carcinogenesis Maintenance of positive mental and emotional health Degeneration of mental and emotional health Reversing process of cellular and systemic health degeneration Cellular and systemic health degeneration Enhancement of and rebuilding of host detoxification capacity Movement toward serious of total impairment of detoxification capacity Movement toward total breakdown of the immune response Priming and rebuilding of the immune response 10 Example 1 Stage AC3 Anti Carcinogenesis Reversing the process Example 1 Stage C3 Carcinogenesis Normalization of vascularization with attendant decrease in nutritional status of tumor cells Increasing vascularization of the tumor with attendant enhancement of nutritional status of tumor cells Enhancement of capacity to get rid of affected cells which can be stimulated by the use of proteolytic enzymes to help break down protective sheath surrounding tumor cells and by stimulating or otherwise enhancing the host’s immune response, enzymatic activity, and detoxification capacity Impairment of capacity to get rid of affected cells owing to protective sheath surrounding tumor cells and overtaxing or absence of an adequate immune response, enzymatic activity, and detoxification capacity of body Strengthening and maintenance of strong ground substance Weakening or undermining of ground substances Return to normal oxygen respiration Respiration of affected cells toward fermentation Example 1 Stage AC4 Anti Carcinogenesis Reversing the process Example 1 Stage C2 Carcinogenesis Repair of DNA or managing of the consequences, including maintaining of fully functioning immune defenses Faulty DNA repair Protection against DNA damage or buffering of the effects DNA damage Preventing or buffering against unwanted free radical reactions Unwanted free radical reactions Assuring the adequacy of free radical scavengering Inadequate free radical scavengers 11 Example 1 Stage AC3 Anti Carcinogenesis Reversing the process Example 1 Stage C3 Carcinogenesis Normalization of vascularization with attendant decrease in nutritional status of tumor cells Increasing vascularization of the tumor with attendant enhancement of nutritional status of tumor cells Enhancement of capacity to get rid of affected cells which can be stimulated by the use of proteolytic enzymes to help break down protective sheath surrounding tumor cells and by stimulating or otherwise enhancing the host’s immune response, enzymatic activity, and detoxification capacity Impairment of capacity to get rid of affected cells owing to protective sheath surrounding tumor cells and overtaxing or absence of an adequate immune response, enzymatic activity, and detoxification capacity of body Strengthening and maintenance of strong ground substance Weakening or undermining of ground substances Return to normal oxygen respiration Respiration of affected cells toward fermentation Example 1 Stage AC5 Anti-Carcinogenesis Reversing the Process Example 1: Stage C1 of 5 Stages of Carcinogenesis Proactive measures to prevent shock or stress and to buffer effects when they occur, including periodic removal from hazardous environmental factors persist Shock, trauma, prolonged stress caused by grief, or stress cause by environmental factors Steps to strengthen cellular integrity of cellular ground substance Weak cellular integrity (including weakening brought about by bacterial, microbial, or viral attack), or cellular ground substance Rectification of dietary imbalances Poor diet, including poorly balanced diet with respect to vitamins, trace elements, amino acids and fatty acids Protection against environmental toxins, mutagens, carcinogens, radiation, include the use of anticarcinogenic regimen Subjection to environmental toxins, mutagens, carcinogens, radiation 12 Example 2 Showing Anti-Carcinogenic Stages Beginning on the Right Hand Side of the Table (Genetic Predisposition) Example 2: Stage C1 of 5 Stages of Carcinogenesis Genetic predisposition Stage AC5 Anti-Carcinogenesis Reversing the Process Protective measures to counter genetic factors which may predispose to cancer Maintenance of good overall health Removal of harmful substances from the diet or in medical, hygienic, or cosmetic regiment Poor overall health Subjection to harmful substances in diet or in medical or hygienic or cosmetic regiment Poor respiration, including that caused by inadequate oxygenation, including that cause by or associated with shallow breathing, anemia, or development atherosclerotic plaque Optimization of respiration including adequate oxygenation, adequate depth of breathing, treatment of anemic or atherosclerotic conditions Stage C2 DNA damage Stage AC4 Protection against DNA damage or buffering of the effects Steps to normalize cell Alteration of normal electrolytic character of the cell Enzymatic alterations Normalization of enzymatic activity Steps to protect against cellular disorganization Cellular disorganization Stage C3 Impairment of capacity to get rid of affected cells owing to protective sheath surrounding tumor cells and overtaxing or absence of an adequate immune response, enzymatic activity, and detoxification capacity of body Stage AC3 Enhancement of capacity to get rid of affected cells which can be stimulated by the use of proteolytic enzymes to help break down protective sheath stimulating or otherwise enhancing the host’s immune response, enzymatic activity, and detoxification capacity Return to normal oxygen respiration Return to normalization of carbohydrate metabolism with return to normalization generally Respiration of affected cells changes toward fermentation Impairment of metabolism with breakdown in carbohydrate metabolism with accompanying impacts of essential body systems Increasing vascularization of the tumor with attendant enhancement of the nutritional status of tumor cells Normalization of vascularization with attendant decrease in nutritional status of tumor cells. 13 Stage C4 Nutritional imbalances, including major imbalances in body chemistry Movement toward serious or total impairment of detoxification capacity Movement toward total breakdown of the immune response Degeneration of mental and emotional health Stage AC2 Restoration of nutritional balance, including balancing of body chemistry in general Enhancement of and rebuilding of host detoxification capacity Stage C5 Near total degeneration of nutritional status and near total imbalance of overall body chemistry Near total collapse of the immune response Near total cellular and systemic health degeneration Stage AC1 Intensified efforts to restore nutritional balance, including balance of body chemistry in general Intensified efforts to prime and rebuild the immune response Intensified efforts to reverse process of cellular and systemic health degeneration Intensified efforts to maintain positive mental and emotional health Priming and rebuilding of the immune response Maintenance of positive mental and emotional health Near total degeneration of mental and emotional health 14 Example 2’ Showing Carcinogenic Stages Beginning on the Right Hand Side of the Table Example 2: 5 Stages of Anti-Carcinogenesis Stage AC1 Reversing the Carcinogenic Process Example2 5 Stages of Carcinogenesis Stage C5 Intensified efforts to maintain positive mental and emotional health Near total degeneration of mental and emotional health Intensified efforts to reverse process of cellular and systemic health degeneration Near total cellular and systemic health degeneration Intensified efforts to prime and rebuild the immune response Intensified efforts to restore nutritional balance, including balance of body chemistry in general Near total collapse of the immune response Near total degeneration of nutritional status and near total imbalance of overall body chemistry Example 2: Stage AC2 Anti-Carcinogenesis Reversing the Carcinogenic Process Example2 5 Stages of Carcinogenesis Stage C4 Degeneration of mental and emotional health Maintenance of positive mental and emotional health Priming and rebuilding of the immune response Movement toward total breakdown of the immune response Enhancement of and rebuilding of host detoxification capacity Movement toward serious or total impairment of detoxification capacity Restoration of nutritional balance, including balancing of body chemistry in general Nutritional imbalances, including major imbalances in body chemistry 15 Example 2: Stage AC3 Anti-Carcinogenesis Reversing the Carcinogenic Process Example2 Stage C3 Carcinogenesis Normalization of vascularization with attendant decrease in nutritional status of tumor cells. Increasing vascularization of the tumor with attendant enhancement of the nutritional status of tumor cells Return to normalization of carbohydrate metabolism with return to normalization generally Impairment of metabolism with breakdown in carbohydrate metabolism with accompanying impacts of essential body systems Respiration of affected cells changes toward fermentation Return to normal oxygen respiration Impairment of capacity to get rid of affected cells owing to protective sheath surrounding tumor cells and overtaxing or absence of an adequate immune response, enzymatic activity, and detoxification capacity of body Enhancement of capacity to get rid of affected cells which can be stimulated by the use of proteolytic enzymes to help break down protective sheath stimulating or otherwise enhancing the host’s immune response, enzymatic activity, and detoxification capacity Example 2: Stage AC4 Anti-Carcinogenesis Reversing the Carcinogenic Process Example2 5 Stages of Carcinogenesis Stage C4 Cellular disorganization Steps to protect against cellular disorganization Normalization of enzymatic activity Enzymatic alterations Alteration of normal electrolytic character of the cell DNA damage Steps to normalize cell Protection against DNA damage or buffering of the effects 16 Example 2: Stage AC5 Anti-Carcinogenesis Reversing the Carcinogenic Process Example2 5 Stages of Carcinogenesis Stage C5 Optimization of respiration including adequate oxygenation, adequate depth of breathing, treatment of anemic or atherosclerotic conditions Poor respiration, including that caused by inadequate oxygenation, including that cause by or associated with shallow breathing, anemia, or development atherosclerotic plaque Removal of harmful substances from the diet or in medical, hygienic, or cosmetic regimen Subjection to harmful substances in diet or in medical or hygienic or cosmetic regimen Maintenance of good overall health Poor overall health Protective measures to counter genetic factors which may predispose to cancer Genetic predisposition Paula D. Gordon, Ph.D. http://GordonCancerTheory.com [email protected] August 25, 2015 Corrected Rendering 17