Download MCB 4211, Basic Immunology Name September 22, 2015 Student

MCB 4211, Basic Immunology
September 22, 2015
Name _________________________________________
Student ID number _______________________________
Quiz 1
SELECT THE BEST ANSWER FROM THE 5 PROVIDED
1. Would you expect a free hapten that is cross reactive with a cognate hapten antigen to be a
successful competitor in a precipitation reaction between an antiserum and its cognate hapten
antigen/carrier protein conjugate?
a. Yes
b. No
2. IgA is found in both the monomeric form as an immunoglobulin with two heavy chains and two
light chains, and also as
a. A pentamer with associated J chain
b. A dimer with associated J chain
c. A hexamer
d. A monomer with J chain
e. All of the above
3. Where are the antigen combining sites of a monomeric antibody molecule?
a. At the carboxy-terminal ends of the two heavy chains
b. At the constant regions of the light chains
c. At the variable region of the light chain and heavy chain
d. At the J chain
e. At the disulfide bridges
4. How do congenic mouse strains differ from co-isogenic mouse strains?
a. Congenic partners differ from each other by a short stretch of one chromosome,
and co-isogenic partner strains differ from each other by the allelic composition
of a single locus
b. They are identical
c. Congenic mice carry an inserted gene from a different species while co-isogenic mice
are unchanged by any insertions.
d. Congenic mice have balanced lethal genes while co-isogenic do not
e. Congenic and Co-isogenic mice differ in the genus they belong to
5. What are critical and essential elements of immunogenicity?
a. Size and complexity
b. pH and ion composition
c. The presence of specific amino acid sequences
d. The presence of lipids
e. All of the above are critical and essential
6. What mechanisms can contribute to the activity of an adjuvant?
a. DNA binding
b. Slow release of antigen, activation of phagocytic activity, and leukocyte
proliferation
c. Apoptosis
MCB 4211, Basic Immunology
September 22, 2015
Name _________________________________________
Student ID number _______________________________
d. Protein degradation
e. Transcription factor binding
7. After twenty generations of brother x sister inbreeding, what characteristics will be associated
with the strain produced
a. Genetically homozygous at most (>98.5%) loci
b. The presence of balanced lethal alleles
c. Residual heterozygozity at some loci as a consequence of random segregation
d. Reduced vigor, litter size, shortened lifespan
e. All of the above
8. The basic antibody molecule structure is composed of
a. Four heavy chains and two light chains that are each different from the rest
b. Two identical heavy chains and two identical light chains
c. One heavy chain and one J chain
d. Five heavy chains, five light chains, and several J chain
e. None of the above
9. Neonatal splenectomy (surgical removal of the spleen at birth) will cause
a. An absence of B cells
b. An absence of NK cells
c. An absence of T cells
d. A reduction of the total B cell pool
e. A reduction of the total leukocyte pool
10. The Bursa of Fabricius is a tissue not found in mammals. What is its equivalent in mammals,
and what does this bursal equivalent do?
a. It is the thymus and is responsible for all cytokine production
b. It is the mesenteric lymph node and it is responsible for developmental maturation of all
B cells
c. It is the fetal liver and the bone marrow, and is responsible for antigenindependent developmental maturation of B cells
d. It is the thyroid and it creates the hormonal environment necessary for immune activity
under stressful conditions
e. It is the ovary, and produces the early pleuripotent hematopoietic stem cells