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Κατερίνα Χαρβάλου 1. Σπουδές-δραστηριότητες: 1974-1982 1984-1988 1991 1996 Πτυχίο Ιατρικής Σχολής Πανεπιστημίου Aθηνών. Διδακτορική διατριβή Ιατρικού τμήματος Παν/μίου Γενεύης με θέμα: Μελέτη Campylobacter jejuni/coli : Κλωνοποίηση και μερική έκφραση αντιγόνων εξωτερικής μεμβράνης Campylobacter jejuni σε Ε. Coli. Ειδικότητα ιατρού μικροβιολόγου Τίτλος εξειδίκευσης στην κλινική μικροβιολογία (υπ υγείας) Υπεύθυνη έκδοσης: Μapping the Maze: Getting more women to the top in research. European Commission, (2008), ISBN 978-92-79-07618-3 Μέλος ιατρικών και Ευρωπαική Επιτροπή επιστημονικών εταιρειών, εμπειρογνώμονας στην Κριτής στα περιοδικά Biotechnology and Bioengineering, Microbial Ecology, Βiofouling. 2. Τομείς ερευνητικών ενδιαφερόντων: Διαγνωστική και μοριακή διαγνωστική των λοιμώξεων. Αντιμικροβιακή αντοχή και νέοι αντιμικροβιακοί παράγοντες (πεπτίδια) και συστήματα αποδέσμευσης (delivery systems). Φύλο, βιοπαθολογία λοιμώξεων και κλιματικές αλλαγές. 3. Συγγραφή βιβλίων: ΔΙΑΓΝΩΣΤ ΙΚΗ Μ ΟΡΙΑΚΗ ΜΙΚΡΟΒΙΟΛΟΓ ΙΑ , Αικατερίνης Χαρβάλου, Ιανουάριος 1998. Ιατρικές Εκδόσεις Π .Χ. Πασχαλίδη. ΣΥΝΟΠΤ ΙΚΗ ΚΥΤΤΑΡ ΙΚΗ ΒΙΟΛΟΓ ΙΑ –Ε ΙΣΑΓΩΓΗ ΣΤΗ ΜΟΡΙΑΚΗ ΒΙΟΛΟΓ ΙΑ ΤΟΥ ΚΥΤ ΤΑΡΟΥ . Iατρικές εκδόσεις Π.Χ. Πασχαλίδη, 2002, Αικ. Χαρβάλου, Διομ. Πηγής, Φιλίππου, Τρίγκας . Πρωτόκολλα κλινικής Μικροβιολογίας. Ιατρικές Πασχαλίδη, 2007 . 4. Διδασκόμενα μαθήματα: 1. Kλινική μικροβιολογία 2. Μεθοδολογία έρευνας 3. Κυτταρική/Μοριακή βιολογία Eκδόσεις Π.Χ. 5. Ενδεικτικές-πρόσφατες δημοσιεύσεις: 1. Shehabi A.A., Z. M. Awad, M. Al-Ramahi , E. Charvalos and L.F. AbuQattouseh Detection of Mycoplasma genitalium and Trichomonas vaginalis Infections in General Jordanian Patients. Αm J Inf Dis (2008), In press 2. Dakic I, Lilakos D, Svabic-Vlahovic M, Christofilipoulou S, Poggas N and E Charvalos. Integron-associated antimicrobial resistance in isolates of members of Enterobacteriaceae causing community-acquired urinary infections. Microb Ecol In Health and Dis (2007) 19:201-206. 3. Alexopoulos, A. Voidarou, C. Stefanis, C. Papadopoulos, I. Vavias, S. Tsiotsias, A. Kalkani, E. Charvalos, E. Bezirtzoglou, E. Antibiotic resistance profiles and integrons in Enterobacteriaceae from the riverside of Evros-Ardas with respect to chemical and waste pollution. Microb Ecol in Health and Dis. (2006), (18); Numb 3-4, pp 170-176. 4. Vassilakopoulou A, Daikos GL, Kosmidis C, Charvalos E, Passiotou M, Avlamis A and G Petrikkos. Class I integrons in Enterobacteriaceae from animals hospitalized and non-hospitalised patients. Archives of Hellenic Medicine (2006) 23 (1): 45-51. 5. Charvalos, E., Tzatzarakis M., Van Bambeke F, Tulkens M., Tsatsakis A. M., Tzanakakis G., and Marie-Paule Mingeot-Leclercq. Water-soluble amphotericin B-polyvinylpyrrolidone complexes with maintained antifungal activity against Candida spp. and Aspergillus spp. and reduced hemolytic and cytotoxic effects. J Antimicr. Chemother. (2006) 57, 236-244. 6. Petrikkos GL, Christofilopoulou SA, Tentolouris NK, Charvalos EA, Kosmidis CJ, Daikos GL.Value of measuring serum procalcitonin, Creactive protein, and mannan antigens to distinguish fungal from bacterial infections. Eur J Clin Microbiol Infect Dis. (2005), 24(4): 272- 6. Επικοινωνία +30 210 5385697, +302105385610 FAX 210 5385866 email: [email protected] Biographical sketch Ekatherina Charvalos Email address: [email protected],Athens: 51, Pipinou str, 112 51. Tel 0030210 6045078 Athens Greece, Dr: Ekatherina Charvalos is a medical doctor, specialized in biopathology, clinical and molecular microbiology. She is a professor of microbiology, molecular biology and research methodology at the Technological Institution of Athens. She has been detached at the EU Commission DG Research, Science in Society -Scientific Culture and Gender issues Unit L4 for two years (2006-2008). She is m arried to Dr George Assonitis and is mother of a unique child. Academic Appointments and professional positions: Research associate at the Department of cellular and molecular pharmacology, Université Catholique de Louvain, Faculté de Médecine, Ecole de Pharmacie (sabbatical, for one academic year) - (2003-2004). Since April 1999 she is a Research associate at the Infectious Diseases Department, University of Athens, Medical School. (Dir. Ass. Prof. Dr. G. Petrikkos). Since November 1997 she is a Prof . of Microbiology/Mol Biology, School of Health Sciences, Medical Laboratories Division. Technological Institution of Athens. Visiting Scientist Tufts Medical School, Center for Adaptation Genetics and Drug Resistance. Dept. of Molecular Biology & Microbi ology (1996-1997) working on Multidrug efflux pumps in gram - negative bacteria. Assistant Professor of Bacteriology University of Crete Medical School (5/1996 - 11/98) Research Associate -Lecturer of Bacteriology. University of Crete, School of Health Sciences (1/1991 - 5/1996), Associate Professor of Parasitology, Mycology and Immunology. Technological Institute of Athens, Greece. Division of Public Health and Medical Laboratories (1990 -1993). Awards, Honors, grants, research projects and affiliations: Dr Ekatherina Charvalos got s even awards for research on mechanisms of resistance in enterobacteriaceae and Campylobacter jejuni, mycoplasmas, and efflux pump. Accomplished research: Fifteen research projects funded by the EEC-Greek government (5 as a c o-ordinator), (10, as a participant). Projects focused on: 1. New antifungal agents of controlled release (Amb -PVP, nystatin-PVP or sorbic acid-PVP), 2. Spread of integrons in nosocomial, non -hospitalised patients, environmental and veterinary strain, 3. D etection of genital mycoplasmas and their antibiotic resistance profile (tri -lateral agreement Greece-France-Serbia), 4. Detection by PCR of M. genitalium in clinical samples (bi-lateral agreement Greece -Romania). 5. Non -invasive methods for the detection of pesticides in human hair, One prize (Empeirikion Institution) for research activities at the University of Geneva. Dr Ekatherina Charvalos is an Expert at the Ministry of Development for Medical Microbiology testing, Expert –evaluator 6th framework pr ogramme, DG Research. FP6 -2003-LIFE SCIENCES HEALTH -I, CRAFT, STREP. Research for the benefit of the SMEs. DG SANCO (EAHC) Call 2009. Member of the Hellenic Society of Microbiology, APUA, ( The alliance for the prudent use of antibiotics) and the American Society for Microbiology. She is offering her services as a Reviewer in peer -reviewing journals (Biotechnology and Bioengineering, Microbial Ecology, Biofouling). Education Certificate of specialization in Clinical Microbiology. (March 1996), Diploma of Specialization in Medical Microbiology (1991), Doctoral Dissertation - Degree of excellence. Doctorat en Médecine. Centre Medical Universitaire de Genève. Department of Genetics & Microbiology (1989), she is a doctor in medicine since 1982, (Ptychion) - University of Athens Medical School, Athens, Greece. Medical Training: She has been resident in biopathology at Hopital Cantonal Universitaire de Geneve. Laboratoire Central de Bactériologie (1984), at the Hospital of the "Sainte Providence, I Pammakaristo s", Athens, 1983, assistant at the regional hospital of Pyrgos, Greece (1982 -1983), and "Assistant -medecin" and Membre légitime de la recherche et de l' enseignement. C.M.U.- H.C.U.G. (Centre Medical Universitaire de Geneve): Departement de Genetique et Microbiolgie. (Doctoral studies 1985 -1988) Post-Doctoral Studies and Training (most important) : Research fellow, University of Geneva, CMU, Dept. of Genetics and Microbiology (2002). Sesame workshop on Bioinformatics, Sabanci University, Istanbul (2001 ), ASM General Meetings (Continuing Medical Education, USA, credits), Laboratory course on PCR application on the diagnosis of mycobacterial, HIV and HBV infections, Roche Diagnostic Center, Nicosia Cyprus (1996), Seminar on "Epidemiology, Health & Environment",Institute Merieux and the University of Savoy, France. FEMS laboratory course on the immunochemical and molecular genetic analysis of bacterial pathogens and their virulence determinants. Trinity College, Dublin, Ireland (1989). Publications (scientific articles -congress participation) She has published about 15 scientific articles in peer -reviewed journals on new antifungals of controlled release, antibiotic resistance efflux mediated, spread of integrons and multidrug resistance in gram -negative strains and she participated in more than 80 congresses. Patent Certificate: Dr. Ekatherina Charvalos is participating (20%), to patent Certificate no 20000100176, 25/5/00, Greek Industrial Property Organisation. The above mentioned certificate is protecti ng PVP -sorbic acid, PVP nystatin, and PVP-amphotericin B complexes. Bibliography Dr E Charvalos is the author of a) “Diagnostic Molecular Microbiology” (1997) Ekatherina Charvalos, Paschalides, Ed. Athens Greece, b) “Synopsis of cellular biology: an in troduction to molecular biology” (2001). E. Charvalos., al., Paschalides ed. Athens, Greece, c) “Clinical Microbiology protocols”, Paschalides Medical ed (2007). Languages and citations: She fluent in Greek, French, English Citacions: more than 600 in sc ientific literature and EU policies (as national detached national expert at the EU Commission, DG RTD, Unit L4 Scientific culture and gender issues). Research and policy areas of interest: a) new polymeric forms of antibiotics: in vitro activity, cytotox icity, bio-compatibility and applications in human and animals b) diagnostic molecular microbiology and molecular epidemiology c) Policies for preventing of antibiotic resistance, d) Genital Mycoplasmas: impact on human health - antibiotic resistance f) Bac terial antibiotic resistance integron or efflux -mediated, e) Dr Ekatherina Charvalos is interested in ethical and gender issues in research and the EU Science in Society policies and international cooperation, f) gender, health and environment in infectiou s diseases. Publications (Most relevant) 1. Adamopoulou M., Kalkani E., Charvalos E., Avgouatidis D., Haidopoulos D., Yapidjakis C. Comparison of cytopology, colposcopy, HPV typing and biomarker analysis in cervical neoplasia. Antricancer Res . (2009) 29(8): 3401 -9. 2. Dakic I, Vassilakopoulou A, Charvalos E, Passiotou M, Petrikkos G. Multidrug resistance and integrons in Escherichia coli isolated from chicken in Greece. Acta Veterinaria (2009) accepted. 3. Shehabi, A., Z.M. Awwad, M. Al-Ramahi, E. Charvalos and L.F. Abu- Qatouseh. Detection of Mycoplasma genitalium and Trichomonas vaginalis Infections in General Jordanian Patients. Am Journal of Infect Dis 5 (1): 7-10, (2009) 4. Dakic I, Lilakos D, Svabic -Vlahovic M, Christofilipoulou S, Poggas N and E Charvalos. Integron -associated antimicrobial resistance in isolates of members of Enterobacteriaceae causing community-acquired urinary infections. Microb Ecol. In Health and Dis. (2007) 19:201-206. 5. Vassilakopoulou A, Daikos GL, Kosmidis C, Charvalos E, Passiotou M, Avlamis A and G Petrikkos. Class I integrons in Enterobacteriaceae from animals hospitalized and non - hospitalised patients. Archives of Hellenic Medicine (2006) 23 (1): 45-51. 6. Charvalos, E., Tzatzarakis M., Van Bambeke F, Tulkens M., Tsatsakis A. M., Tzanakakis G., and Marie -Paule Mingeot Leclercq. Water-soluble amphotericin B -polyvinylpyrrolidone complexes with maintained antifungal activity against Candida spp. and Aspergillus spp. and reduced hemolytic and cytotoxic effects. J Antimicr. Chemother. (2006) 57, 236-244. 7. Petrikkos GL, Christofilopoulou SA, Tentolou ris NK, Charvalos EA, Kosmidis procalcitonin, CJ, Daikos C -reactive GL. Value protein, and of measuring mannan serum antigens to distinguish fungal from bacterial infections. Eur J Clin Microbiol Infect Dis.(2005), 24(4): 272-5. 8. Alexopoulos A, Voidarou C, Stefanidis C, Papadopoulos I, Vavias S, Kalkani E, Charvalos E and E Bezirtzoglou. Antibiotic resistance profiles and integrons in Enterobacteriaceae from the riverside Evros -Ardas with respect to chemical pollution (extended abstract) Microb Ecol. In Hea lth and Dis. (2006) vol 18: 170-176. 9. Christofilopoulou, S., E. Charvalos, G. Petrikkos. Could procalcitonin be a predictive biological marker in systemic fungal infections? Study of fourteen cases. European Journal of Internal Medicine, (2002) 13:493-495. 10. Charvalos E., M. Tzatzarakis, M. Tsatsakis & G. Petrikkos Controlled release of water soluble polymeric complexes of sorbic acid with antifungal activities Appl. Microbiol.& Biotechnol . (2001) 57: 770-775. 11. Charvalos E., Tsatsakis A., Tzatzarakis M, Dola psakis G., Stiakakis J. New nystatin polymeric complexes and their in vitro antifungal evaluation in a model study with Fusarium oxysporum. Mycopathologia, (2001), 153: 15 -19. 12. Charvalos, E., Karoutis, A.D. Antimicrobial activity of ArF excimer Laser radia tion in gram- negative bacteria. Appl. Microbiol. & Biotechnology , (2001), 56(1-2): 243-8. 13. Tzatzarakis, A. Tsatsakis, Charvalos E., Vakalounakis, D. Comparison of in vitro activities of amphotericin, clotrimazole, econazole, miconazole and nystatin agai nst Fusarium oxysporum. J. Env. Health. (2001), 36(3): 331-40. 14. Hαdjichristodoulou C., Papatheodorou C., Sotiriades E., Panagakos G., Charvalos E. Tselentis. Epidemiological study of brucellosis in eight Greek villages using a computerised mapping programme. Eur. J. of Epidemiol. (1999), 15 (7): 671-680. 15. Charvalos, E., Peteinaki, E., Spyridaki, I., Manetas, S., and Tselentis, Y. Detection of ciprofloxacin resistance mutations in Campylobacter jejuni by non-radioisotopic Single Strand conformation polymporphism and direct DNA sequencing. J. Clin. Lab. Analysis Vol. X, (1996), 10 (3): 129 -133. 16. Karoutis A. D., Z. Guiti, E. Charvalos, I. Tselentis and E. Helidonis. Bactericidal effect of ArF Excimer laser radiation. I. Gramnegative bacteria. Lasers in the Life Science. (1996), 7(1) pp. 1-12. 17. Charvalos, E., Tselentis, Y., Hamzehpour, M.M. and Pechere, J.C., Evidence for an efflux pump in multidrug resistant Campylobacter jejuni. Antimicrobial Agents and Chemotherapy, (1995), 39, XI, pp.2019 -2022. 18. Charvalos E., V. Houlakis, and Y. Tselentis. Probe identification of Campylobacter species in the Mediterranean island of Crete and susceptibility profile to ciprofloxacin. Μedit. J. of Infect. and Parasit. Dis. Issue October - December. (1995) Vol. X, No 4, p. 200-202. 19. Charvalos E., S. Manetas, A. Georgiladakis and J. Tselentis. Epidemiological investigation of toxoplasmosis in rural areas in Greece. Mediterranean Journal of Infectious and Parasitic Diseases. October - December (1995) Vol. X, No 4, p. 177 -199. 20. Manetas S., J. Tselentis, and E. Charvalos. Epidemiological investigation of human brucellosis in Greece. Italian Journal of Clinical Pathology. (1989), Vol. IV, N. 6 December p. 393 -396. Greek publications and production of educational material In Acta micribiologica Hellenica the official journal of the Hellenic Microbiology Association more than five scientific articles and reviews; in other Greek journals pub lications of peer reviewed articles. Short manual (notes) for the students (Molecular biology medical microbiology –research methodology). Video of the laboratory course on Molecular Biology BOOKS 1. Diagnostic Molecular Microbiology , Paschalides Medical Editions, Athens (1998). 2. Synospsis of cellular biology: an introduction to molecular biology. Paschalides Medical Editions, Athens, (2002), ISBN: 960-399-092-2. 3. Clinical Microbiology protocols . Paschalides Medical editions, (2007) ISBN: 978 -960-399-542-5. CONGRESS ABSTRACTS (most relevant, from about 95) 1. E. Charvalos, A. Vassilakopoulou, G. Daikos, M. Passiotou, I. Dakic, G. Petrikkos. Charvalos Ekatherina, Integrons and Multidrug Resistance (MDR) in Enterobacteriaceae from Food Producing Poultry. ASM 107 General Meeting, 24/26 May 2007, Toronto, 07 -GM-A-2436-ASM Canada. 2. Dakic I, Svabic M, Kalkani E, Charvalos E. "Pathogenic antibiotic resistant bacteria in the poultry husbandry environment in Greece: Investigation of the phenomenon. Are there methods to control this issue?" The second Jordanian, International congress in Immunology and allergy, Amman, Jordan May 30 -2 June, 2007. 3. Ivana Dakic, Dinos Lilakos, Milena Svabic -Vlahovic, Sofia Christofilopoulou, Nikos Poggas and Ekatherina Charvalos. Integron and Tn21 associated antibiotic resistance in Enterobacteriaceae from community and hospital urine tract infection (UTI), Current status αnd future Scenarios. Caire, 11 -16 December 2006. 4. Alexopoulos A, Voidarou C, Stefanidis C, Papadopoulos I, Vavias S, Kalkani E, Charvalos E and E Bezirtzoglou. Antibiotic resistance profiles and integrons in Enterobacteriaceae from the riverside Evros Ardas with respect to chemical pollution (extended abstract) Microb Ecol. In Health and Dis. (2006) vol 18: 170 -176. 5. Fanariotis D., Svabic Vlahovic M., Antonopoulou S., Vassilopoulos J., Kalkani E., Kouroussis A., Cernescu C. , Charvalos E. , Bebear C. . The European network for genital mycomplasmas Prevalence of genital mycoplasmas and their susceptibilities in three Balkan countries. Sexually transmitted infections congress, Mykonos 7 -9 October 04. 6. Aexandra Vassilakopoulou, G. L. Daikos, L. Tzouvele kis, C. Kosmidis, E. Charvalos, A. Avlamis, G. Petrikkos. Prevalence of Class 1 Integrons in Enterobacteriaceae from hospitalized Patients. ISDA, USA, October 04. hospitalized and Non - 7. Ηatjisoteriou M., Charvalou K., E Toufeksi, A Lagadas, G Sarikakis, G. Petrikkos. Prevalence of genital mycoplasmas and their susceptibilities to antimicrobial agents. EEC, 5th European congress of chemotherapy and infection 17 -20 October 2003 Rhodes. 8. Vallianou N, Fourtziala E, Togas D, Miltiadous M, Gourni A, Charvalos E and G. Petrikkos Epidemiological study of antibiotic resistant Staphylococcus aureus strains in a general hospital of Cyprus. 1st pancyprian congrees of chemotherapy and infectious diseases 31/3 /2000, Nicosia, Cyprus 9. Charvalos, E., M.N. Tzatzarak is, F. Van Bambeke, P.M. Tulkens, A.M. Tsatsakis, M -P Mingeot-Leclercq In-vitro antifungal activity, cytotoxicity and cellular accumulation of new water -soluble amphotericin B (AMB) – polyvinylpyrrolidone (PVP) formulations. ESCMID, Prague May 2-5 2004. 10. Charvalos E., Charis Liapi, Aristeidis Tsatsakis, Manolis Tzatzarakis, Panagiota Galanopoulou, Charis Koutis. New nystatin polymeric complexes and their in vitro antifungal evaluation in a model study with F. oxysporum. XIV World congress of Pharmacolo gy. July 712. (2002) Moscone convention centre, San Franscisco, CA. 11. Charvalos E., Tzatzarakis M., Tsatsakis A., & M. I. Shtilman. Antifungal activities of novel controlled release water -soluble polymeric forms of sorbic acid. ICAAC Toronto, September 17-20, 2000. 12. Charvalos E., Tsatsakis A., Tzatzarakis M., Kanta A., Georgopoulos I, Petrikkos G. Antifungal activities of novel controlled release water soluble polymeric forms of sorbic acid. 6th World Hellenic Biomedical Congress, Athens 12 -14 October 2000. 13. Charvalos, E. & A. Karoutis. Antimicrobial Activity of Arf Excimer Laser on Gram negative Bacteria. ASM General Meeting.Chigago, May 28-June 2, 1999. 14. Irini Galani, E. Charvalos & H. Giamarellou. Mechanisms of quinolone resistance in cli nical strains of Acinetobacter baumannii . EEC, Hamburg, 11 May 1998. 15. Achilleas Gikas, Ioanna Spyridaki, Diamantis Kofterides, Aikaterini Charvalos, Αnna Psaroulaki & J. Tselentis. Isolation and genotypic identification of Coxiella burnetii in 158 cases of Q fever. 1st International Meeting of Chemotherapy, of the European Society of Chemotherapy, Athens 21 -24 May 1996.