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GENETICS BIOL 3413.04
Fall 2016
MW 4:30-5:45 ESCNE 2.102
Text:
Mark Scally, PhD
[email protected]
MW 3:00-3:30, 6:00-6:30
An Introduction to Genetic Analysis. 2015 A.F.J. Griffiths, S.R. Wessler, S. B. Carroll
and J. Doebley. 11th Edition. W.H. Freeman and Company. The textbook is be available
new. Used copies of the 10th Edition will still be fully serviceable for the course.
Grading: There will be four lecture exams given, each of which covers the materials from lecture,
handouts, problem sets, and assigned readings. Each exam will be worth 125 points.
There will be no exemptions from any exams and no exams will be given early. An
additional 250 points will be available in the form of graded problem sets and homework
assignments. There will be a total of 750 points in the lecture portion of the course. The
lecture grade will make up 75% of the final course grade, with the other 25% coming from
the laboratory grade. Final grades will be determined on a standard scale (90, 80, 70, 60)
with no curve
All lecture make up exams will be given during dead days at the end of the semester. The
make up will be a generalized, comprehensive make up exam. This will be the only time
for make up exams. Late home work will be accepted with a substantial penalty. 25% of
the assignment's value is lost for each day late. After 4 days a zero will be recorded.
Class:
Tardiness will not be tolerated. Be on time!!! There will be no eating, drinking, or
smoking during lecture. Questions during lecture are encouraged, however social
conversations will not be tolerated. Please turn off or silence all cell phones and beepers
during class.
Biology Student Learning Outcomes (core curriculum course):
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Principles of Heredity: Students will be able to
o explain Mendel’s principles of inheritance and apply these to problems of inheritance
o describe the different forms of inheritance patterns and identify these in genetic data
o use and interpret probabilities and statistics in the gathering, predicting, and analysis of genetic data
o describe various types of genetic crosses and indicate when/why they would be used by a geneticist
o explain more complex modes of inheritance and how sex influences the inheritance and expression of
genes (e.g. sex-influenced traits, cytoplasmic inheritance, genomic imprinting)
o use this information in predicting genetic outcomes and the analysis of genetic data
Cell and Organism Reproduction: Students will be able to
o describe cellular and chromosomal events that occur during the eukaryotic cell cycle and gamete
formation
o describe chromosome behavior and changes in chromosome structure and number as a cell progresses
through a cell cycle, meiosis I and meiosis II
o explain how meiosis and random fertilization contribute to genetic variation in sexually reproducing
organisms
Pedigrees: Students will be able to apply principles of heredity in assessment of pedigrees to identify genotypes of
family members, conclude the mode of inheritance for a trait, and predict mating outcomes.
Eukaryotic Gene Mapping: Students will be able to
o compare the effect of linkage and independent assortment on genetic outcomes and assess data to
determine if genes are linked or on separate chromosomes
o explain how crossing over produces recombination and use recombination frequencies to construct a
genetic map
o use genetic maps to predict gametic and mating outcomes
o describe some of the methods that can be used to place a gene on a particular chromosome (e.g. FISH)
Chromosome Variation and Structure: Students will be able to
o describe and recognize a variety of abnormalities in chromosome structure and number and explain how
these anomalies arise and are detected
o explain the molecular structure of chromosomes as it relates to storage, gene expression, and sequence
function
Nucleic Acid Structure: Students will be able to
o describe early studies that led to DNA as the genetic material and/or interpret results from these studies
o describe the molecular structure of DNA and RNA and indicate similarities and differences
DNA Replication: Students will be able to
o describe the historic experiment that demonstrated DNA replication follows a semi-conservative model
o describe the process of DNA replication in prokaryotes at the biochemical level
o explain how proofreading and repair is accomplished during DNA synthesis
o describe how DNA is replicated in viruses, plasmids, and eukaryotes and identify similarities and
differences between these and replication in prokaryotes
Gene Expression: Students will be able to
o describe at the biochemical level the events that occur to go from gene to phenotype
o identify different types of RNA, note their properties, how they are processed to yield a functional
form, and their function in gene expression
o recognize the importance of regulating gene expression in prokaryotes and eukaryotes and describe the
levels at which gene expression is controlled and the mechanisms used by prokaryotes and eukaryotes
Mutations: Students will be able to define and identify the various types of mutations that occur at the DNA and
protein levels and explain and recognize the relationship between mutations and new alleles.
TENTATIVE LECTURE SCHEDULE
Genetics 3413.04
DATE
Aug.
Sept.
Oct.
Nov.
Dec.
TOPIC
39
31
5
7
12
14
19
21
26
28
3
5
10
12
17
19
24
26
31
2
7
9
14
16
21
23
28
30
5
7
TBA
Introduction
Mendelian Genetics
NO CLASS – LABOR DAY
Mendelian Genetics
Mendelian Genetics
Mitosis and Meiosis
Mitosis and Meiosis
EXAM I
Sex Determination
Sex Linkage
General Linkage and Crossing Over
Gene Mapping
Variation in Chromosome Number
Variation in Chromosome Structure
Chromosome Replication/Fine Structure
EXAM II
Nucleic Acid Structure and Replication
Fine Structure - Biochemical Genetics
Bacterial Genetics
Genetic Engineering
Gene Expression
Molecular Aspects of the Gene
Mutation
EXAM III
Repair Systems
Transposable Elements
Gene Regulation in Prokaryotes
Gene Regulation in Eukaryotes
Extra-chromosomal Inheritance
Review
FINAL EXAM IV
CHAPTER
1
2
3
6
2
2
2
2
4
4
17
17
7
7
8
5
9
10
10
16
16
15
11
12
13
STUDENTS WITH DISABILITIES: If you have a documented disability (physical, psychological, learning, or
other disability which affects your academic performance) and would like to receive academic
accommodations, please inform your instructor and contact Student Accessibility Services to schedule an
appointment to initiate services. It is recommended that you schedule an appointment with Student
Accessibility Services before classes start. However, accommodations can be provided at any time.
Brownsville Campus: Student Accessibility Services is located in Cortez Hall Room 129 and can be contacted
by phone at (956) 882-7374 (Voice) or via email at [email protected]. Edinburg Campus: Student
Accessibility Services is located in 108 University Center and can be contacted by phone at (956) 665-7005
(Voice), (956) 665-3840 (Fax), or via email at [email protected].
MANDATORY COURSE EVALUATION PERIOD: Required on all syllabi. Do not modify.
Students are required to complete an ONLINE evaluation of this course, accessed through your UTRGV
account (http://my.utrgv.edu); you will be contacted through email with further instructions. Students who
complete their evaluations will have priority access to their grades. Online evaluations will be available: Nov
18 – Dec 8 for full fall semester courses
ATTENDANCE: Students are expected to attend all scheduled classes and may be dropped from the course for
excessive absences. UTRGV’s attendance policy excuses students from attending class if they are
participating in officially sponsored university activities, such as athletics; for observance of religious holy
days; or for military service. Students should contact the instructor in advance of the excused absence and
arrange to make up missed work or examinations.
SCHOLASTIC INTEGRITY: As members of a community dedicated to Honesty, Integrity and Respect, students
are reminded that those who engage in scholastic dishonesty are subject to disciplinary penalties, including
the possibility of failure in the course and expulsion from the University. Scholastic dishonesty includes but is
not limited to: cheating, plagiarism, and collusion; submission for credit of any work or materials that are
attributable in whole or in part to another person; taking an examination for another person; any act
designed to give unfair advantage to a student; or the attempt to commit such acts. Since scholastic
dishonesty harms the individual, all students and the integrity of the University, policies on scholastic
dishonesty will be strictly enforced (Board of Regents Rules and Regulations and UTRGV Academic Integrity
Guidelines). All scholastic dishonesty incidents will be reported to the Dean of Students.
SEXUAL HARASSMENT, DISCRIMINATION, and VIOLENCE: In accordance with UT System regulations, your
instructor is a “responsible employee” for reporting purposes under Title IX regulations and so must report
any instance, occurring during a student’s time in college, of sexual assault, stalking, dating violence, domestic
violence, or sexual harassment about which she/he becomes aware during this course through writing,
discussion, or personal disclosure. More information can be found at www.utrgv.edu/equity, including
confidential resources available on campus. The faculty and staff of UTRGV actively strive to provide a
learning, working, and living environment that promotes personal integrity, civility, and mutual respect in an
environment free from sexual misconduct and discrimination.
COURSE DROPS: According to UTRGV policy, students may drop any class without penalty earning a grade of
DR until the official drop date. Following that date, students must be assigned a letter grade and can no longer
drop the class. Students considering dropping the class should be aware of the “3-peat rule” and the “6-drop”
rule so they can recognize how dropped classes may affect their academic success. The 6-drop rule refers to
Texas law that dictates that undergraduate students may not drop more than six courses during their
undergraduate career. Courses dropped at other Texas public higher education institutions will count toward
the six-course drop limit. The 3-peat rule refers to additional fees charged to students who take the same
class for the third time.