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Health Benefits of Olive Oil UC Davis Sensory Evaluation of Olive Oil April 5, 2008 Peter Panagotacos M.D. San Francisco Lykovouno Extra Virgin Olive Oil • History of Medicinal Use of Olive Oil • Systemic and Topical Benefits • Studies Done to Prove Benefits of Olive Oil What is in Olive Oil and what makes it healthy? Monounsaturated fat (Oleic Acid) Squalene Phenols Vitamine K Vitamin E Oleocanthal Antioxidant Chlorophyll (Green) Carotenoids (Yellow red) What Makes Olive Oil Healthy? Maintain suppleness of skin, muscles and abrasions. It sooths dry skin from effects of sun and wind Aid in digestion Promotes hair growth Slow ageing process Prevent heart disease Prevent diabetes Prevents certain cancers Lowers bad cholesterol Lowers blood pressure Relieving aching muscles Dermatology and the Benefits of Olive Oil With skin and skin cancers Prevents ageing and gives sheen to skin Heals abrasions It is a internal and external benefit to the body as well as beauty The Phenolic compound it five times greater than vitamin E and is a highly active hydroxytyrosal antioxidant Coffee Berry is now being clinically proven to reduce signs of ageing (Revaleskin) Olive oil delays the onset and reduces the number of UV induced skin cancers Ancient Greeks Hippocrates, the father of medicine Ancient Greeks believed that Virgin Olive Oil is beneficial to human health and recommended it for afflictions such as: Dermatological problems lacerations and burns Gynecological diseases Inducement of vomit Ear infections Birth control According to the code established by the father of medicine, Hippocrates, olive oil was held beneficial for over 60 therapeutic uses. Mediterranean Diet The greatest exponent of monounsaturated fat is olive oil, and it is a prime component of the Mediterranean Diet. Olive oil is a natural juice which preserves the taste, aroma, vitamins and properties of the olive fruit. Olive oil is the only vegetable oil that can be consumed as it is - freshly pressed from the fruit. The beneficial health effects of olive oil are due to both its high content of monounsaturated fatty acids and its high content of antioxidative substances. Studies have shown that olive oil offers protection against heart disease by controlling LDL ("bad") cholesterol levels while raising HDL (the "good" cholesterol) levels. (1-3) No other naturally produced oil has as large an amount of monounsaturated as olive oil -mainly oleic acid. Olive Oil Per Capita Consumption Greece Spain Italy EU Australia USA 26.1 liters (½ liter/wk) 15.0 liters 13.5 liters 5.4 liters 1.2 liters 0.6 liters Oleic Acid (cis form) Oleic acid is a common fatty acid found in most animal and vegetable fats. It contains one double bond (at the bottom of the "v"). Note that each of those carbon atoms is linked to only one hydrogen atom, instead of two. Oleic acid is a mono-unsaturated fat, which means it has only one double bond. Polyunsaturated fats contain two or more double bonds. Fatty acids can be short, medium, or long—containing anywhere from 4 to 28 carbon atoms in the chain. Butyric acid contains 4 carbon atoms and is saturated with hydrogen atoms. The omega-3 called docosahexaenoic acid (DHA), which is commonly found in fish oil, contains 22 carbon atoms and 6 double-bond kinks, making it extremely polyunsaturated. Because unsaturated fats have this "kink" or bend, the molecules do not stack together easily—so they stay fluid at room temperature. Some mono-unsaturated fats, such as olive oil, will solidify when cooled in the refrigerator. Poly-unsaturated fats, which have more double-bonds and therefore more bends in their physical structure, stay fluid even when refrigerated. Oleic Acid When plants or animals make unsaturated fats, they mostly build this kinked "cis" form. However, food manufacturers discovered that bubbling hydrogen through polyunsaturated oils created "partially hydrogenated" fats that were less vulnerable to becoming rancid than the original oils and therefore had a longer shelf life. Oleic Acid (trans) These partially hydrogenated margarines and shortenings are now present in almost all baked goods and commercial peanut butter. This hydrogenation process also converts the bent "cis" form to a straightened "trans" form, which looks like this: Olive oil's health benefits Olive oil is a natural juice which preserves the taste, aroma, vitamins and properties of the olive fruit. Olive oil is the only vegetable oil that can be consumed as it is - freshly pressed from the fruit. The greatest exponent of monounsaturated fat is olive oil, and it is a prime component of the Mediterranean Diet. LDL vs. HDL The beneficial health effects of olive oil are due to both its high content of monounsaturated fatty acids and its high content of antioxidative substances. Studies have shown that olive oil offers protection against heart disease by controlling LDL ("bad") cholesterol levels while raising HDL (the "good" cholesterol) levels. (1-3) No other naturally produced oil has as large an amount of monounsaturated as olive oil -mainly oleic acid. Type of fat Monounsaturated Polyunsaturated Saturated Other elements 74 % Olive oil 8% 14 % 4% Canola oil 59 % 30 % 7% 4% Peanut oil 46 % 32 % 17 % 5% 24 % 59 % 13 % 4% Soybean oil 23 % 58 % 14 % 4% Sunflower oil 20 % 65 % 10 % 5% 14 % 75 % 6% 5% 63 % 9% 5% 2% 81 % 6% 9% 50 % 4% 2% 86 % 6% 4% 62 % 4% 37 % 29 % 4% 4% 50 % Corn oil Safflower oil 23 % Walnut oil Palm kernel oil 11 % 37 % Palm oil 6% Coconut oil 30 % Butter 30 % Shortening Tallow (rendered fat of cattle or sheep) 42 % So why does olive oil lower blood pressure? One possible reason is its polyphenol content. Polyphenols are potent antioxidants which help arteries dilate, thereby reducing blood pressure. Ten grams of extra-virgin olive oil contains five mg of polyphenols; sunflower oil has no polyphenols. Diabetes Benefits Diabetes Benefits From Olive Oil People living with diabetes have to work hard to keep their blood sugar, also called blood glucose, levels under control. One way to do so is to eat a diet that is fairly low in carbohydrates. Because people with diabetes are also at an elevated risk of developing heart disease, they are advised to limit their intake of dietary fat. Oleic Acid Oleic Acid - oleic acid (omega 9) makes up 55 - 85 percent of the fatty acids in olive oil. Don't confuse this with the amount of free oleic acid which is the main factor used to determine the grade of the olive oil and the lower the better. It's great for your skin read about common oils used in soaps and how they can do so much more than just clean your skin. Oleic acid aids in keeping our arteries supple and helps prevent cancer Polyphenols Heart Health and Cholesterol - extra virgin olive oil is high in polyphenols (a powerful antioxidant) and monounsaturated fat which contributes to lowering bad cholesterol. Blood Pressure Blood Pressure - Studies now indicate that extra virgin olive oil may help to lower blood pressure. Patients were able to reduce or eliminate the need for medications when olive oil was consumed on a regular basis. In March 2005 U.S. Food and Drug Administration credited olive oil with decreasing the risk of coronary heart disease. Alzheimers Alzheimers - this disease is associated with the clogging of arteries caused by cholesterol and saturated fat. Replacing other fats with olive oil will reduce the risk. Gallstones Gallstones - Olive oil promotes the secretion of bile and pancreatic hormones naturally and lowers the incidence of gallstones. What Is Oleocanthal and How Can It Help You? – An article published by Philadelphia researchers in the September 2005 issue of Nature identified a compound in olive oil called oleocanthal that has anti-inflammatory action. Their studies revealed that this compound can act like ibuprofen and other anti-inflammatory medications. Inflammation Benefits From Olive Oil Inflammation within the body may occur in response to cigarette smoking or eating large amounts of saturated fat and trans fat. In overweight or obese people, excess fat from fat cells can float through the bloodstream and cause inflammation. Inflammation Certain dietary fats cause more of an inflammatory response than others. Trans fat and the saturated fat in animal foods stimulate inflammation. To a smaller extent, polyunsaturated fat in foods such as safflower oil, sunflower oil, and corn oil trigger inflammation, as well. Again, this is where olive oil helps. Olive oil's phytonutrients -- in this case phenolic compounds called squalene, beta-sitosterol, and tyrosol -don't cause the inflammation that other fats do. Cancer Cancer is the second leading cause of death in the United States next to heart disease, and will claim more than half a million lives this year. WHY OLIVE OIL? It is the only added lipid [fat] that has not been associated with increased risk of cancer," said Dimitrios Trichopoulos, an epidemiology professor at Harvard University in Cambridge, Massachusetts. Cancer prevention Cancer - researchers at the University of Oxford believe that olive oil may be just as effective in the prevention of colon cancer as fresh fruits and veggies. A diet rich in olive oil has been shown to reduce the incidence of colon., breast and skin cancers. Breast Cancer Olive oil may actually prevent cancer, according to a study released earlier this year. The study showed that oleic acid, the main monounsaturated fatty acid in olive oil, can cripple a cancer gene responsible for 25 to 30 percent of all breast cancers. Food and Drug Administration Olive Oil Makers are allowed to say on their labels that there is “ limited and not conclusive” evidence that people could reduce the risk of coronary disease by replacing saturated fats in their diets with olive oil. References Peter Panagotacos M.D. Dermatology of San Francisco CA 94123 Peter Panagotacos M.D. Owner of Lykovouno Extra Virgin Olive Oil Company [email protected] Olive oil and the haemostatic system Molecular Nutrition & Food Research Volume 51, Issue 10, Date: October 2007 Amazingoliveoil.com Dermatitis Herbal Topical, Quick Read March 2008 by Dr Torok www.dermatologytimes.com FDA.com Health Benefits of olive oil 2005 www.Revaleskin.com Dimitrios Trichopoulos, an epidemiology professor at Harvard University in Cambridge, Massachusetts. Dimitrios Trichopoulos, an epidemiology professor at Harvard University in Cambridge, Massachusetts. Pancreatic CancerTreatment For Pancreatic Cancer Find treatment info online.TreatmentIdeas.org Pancreatic Cancer SurgeryJefferson Hospital sets standard for pancreatic cancer treatmentwww.jeffersonhospital.org Colon and Rectal CancerRegular Screening Can Prevent It. If You're Over 50 You Need to Know.www.TabletPrep.com Pancreatic Cancer SymptomFind - Pancreatic Cancer Symptoms. Pancreatic Cancer Symptoms Guide.Pancreaticcancerhazard.com Nationalgeographic.com news March 21, 2005 Olive Oil Fights heart Disease, Breast Cancer, studies Oliveoilsource.com 12 14 07, The Olive Oil Source By John Deane M.D., Concerns with Olive The New England Journal of Medicine Volume 348:2595-2596 June 26, 2003 MayoClinic.com Tools for healthier lives 03 29 08 Paul Vossen Olive Oil and Health (In The Literature) American Diabetes Association. 1994 position Statement: Nutritional Recommendations and Principals for people with diabeties mellitus. Diabetes Care, 17, pp 519-522 International Olive Oil Council. 1997. World Olive Encyclopedia. Madrid, Spain. FDA News 2004. FDA Allows Qualified Health Claim to Decrease Risk Of Coronary Heart Disease. http://www.fda.gov/bbs/topics/news/2004/NEW01129.html Mediterranean diet, olive oil and health European Journal of Lipid Science and Technology Volume 104, Issue 9-10, Date: October 2002, Pages: 698-705 Ursel Wahrburg, Mario Kratz, Paul Cullen A unifying hypothesis of Alzheimer's disease. III. Risk factors Human Psychopharmacology: Clinical and Experimental Volume 15, Effect of Alkanna albugam root on LDL oxidation. A comparative study with species of the Lamiaceae family Phytotherapy Research Volume 19, Issue 12, Date: December 2005, Pages: 1077-1079 Andriana C. Kaliora, Nikolaos K. Andrikopoulos Astrazon Red dye decolorization by growing cells and pellets of Funalia trogii Journal of Basic Microbiology Volume 44, Issue 4, Date: July 2004, Pages: 263-269 Seval Cing, Ozfer Yesilada Optimization of a feed medium for fed-batch culture of insect cells using a genetic algorithm Biotechnology and Bioengineering Volume 81, Issue 3, Date: 5 February 2003, Pages: 269-278 R. C. L. Marteijn, O. Jurrius, J. Dhont, C. D. de Gooijer, J. Tramper, D. E. Martens Analytical determination of antioxidants in tomato: Typical components of the Mediterranean diet Journal of Separation Science Volume 30, Issue 4, Date: March 2007, Pages: 452-461 María Gómez-Romero, David Arráez-Román, Antonio Segura-Carretero, Alberto FernándezGutiérrez Oxidative stability of virgin olive oil European Journal of Lipid Science and Technology Volume 104, Issue 9-10, Date: October 2002, Pages: 661-676 Joaquín Velasco, Carmen Dobarganes Instrumental technique evolution for olive oil sensory analysis European Journal of Lipid Science and Technology Volume 109, Issue 5, Date: No. 5 May 2007, Pages: 536-546 Contribution of phenolic compounds to virgin olive oil quality European Journal of Lipid Science and Technology Volume 104, Issue 9-10, Date: October 2002, Pages: 602-613 Maurizio Servili, GianFrancesco Montedoro Malaxing temperature affects volatile and phenol composition as well as other analytical features of virgin olive oil European Journal of Lipid Science and Technology Volume 103, Issue 4, Date: April 2001, Pages: 228-238 Olive oil and oxidative stress Molecular Nutrition & Food Reer 2007, Pages: 1215-1224 Montserrat Fitó, Rafael de la Torre, María-Isabel Covas Characterisation of monovarietal virgin olive oils European Journal of Lipid Science and Technology Volume 104, Issue 9-10, Date: October 2002, Pages: 614-627 Ramón Aparicio, Guadalupe Luna Influence of volatile compounds on virgin olive oil quality evaluated by analytical approaches and sensor panels European Journal of Lipid Science and Technology Volume 104, Issue 9-10, Date: October 2002, Pages: 639-660 Franca Angerosa Effect of olive paste kneading process time on the overall quality of virgin olive oil European Journal of Lipid Science and Technology Volume 105, Issue 2, Date: February 2003, Pages: 57-67 Alfonso Ranalli, Luciano Pollastri, Stefania Contento, Emilia Iannucci, Lucia Lucera Vasculoprotective potential of olive oil components Molecular Nutrition & Food Research Volume 51, Issue 10, Date: October 2007, Pages: 1225-1234 Maria Annunziata Carluccio, Marika Massaro, Egeria Scoditti, Raffaele De Caterina The influence of olive oil on human health: not a question of fat alone Molecular Nutrition & Food Research Volume 51, Issue 10, Date: October 2007, Pages: 1199-1208 Francisco Pérez-Jiménez, Juan Ruano, Pablo Perez-Martinez, Fernando Lopez-Segura, Jose Lopez-Miranda Influence of olive processing on virgin olive oil quality European Journal of Lipid Science and Technology Volume 104, Issue 9-10, Date: October 2002, Pages: Comparability and reliability of different techniques for the determination of phenolic compounds in virgin olive oil European Journal of Lipid Science and Technology Volume 106, Issue 8, Date: August 2004, Pages: 540-549 Karel Hrncirik, Sonja Fritsche Characterization of olive paste volatiles to predict the sensory quality of virgin olive oil European Journal of Lipid Science and Technology Volume 109, Issue 7, Date: No. 7 July 2007, Pages: 663-672 Diego L. García-González, Noelia Tena, Ramón Aparicio Improving olive oil quality using CO2 evolved from olive pastes during processing European Journal of Lipid Science and Technology Volume 108, Issue 11, Date: No. 11 November 2006, Pages: 904-912 Alessandro Parenti, Paolo Spugnoli, Piernicola Masella, Luca Calamai, Ottorino Luca Pantani Effect of olive fruit freezing on oxidative stability of virgin olive oil European Journal of Lipid Science and Technology Early View Alba Poerio, Alessandra Bendini, Lorenzo Cerretani, Matteo Bonoli-Carbognin, Giovanni Lercker Antioxidant and other biological activities of phenols from olives and olive oil Medicinal Research Reviews Volume 22, Issue 1, Date: January 2002, Pages: 65-75 Francesco Visioli, Andrea Poli, Claudio Gall Characterization of virgin olive oil from Southern Tunisia European Journal of Lipid Science and Technology Volume 110, Issue 1, Date: No. 1 January 2008, Pages: 81-88 European Journal of Lipid Science and Technology Volume 110, Issue 1, Date: No. 1 January 2008, Pages: 81-88 Wissem Zarrouk, Faouzia Mahjoub Haddada, Bechir Baccouri, Imen Oueslati, Wael Taamalli, Xavier Fernandez, Louisette LizzaniCuvelier, Douja Daoud, Mokhtar Zarrouk Sensory Evaluation of Virgin Olive Oils by Artificial Neural Network Processing of Dynamic Head-Space Gas Chromatographic Data Journal of the Science of Food and Agriculture Volume 72, Issue 3, Date: November 1996, Pages: 323-328 Franca Angerosa, Luciana Di Giacinto, Raffaella Vito, Sergio Cumitini