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PANCREAS REVIEW
Dr. Ayisha Qureshi
A patient came to a clinician with a past 2-3 weeks history of muscle weakness with tetanic condition. His urine
coloration is intense with polyuria. He is suffering from polydypsia and lethargic condition. Patient also
complains of sudden weight loss.
After suggestion by the doctor for Lab tests, following are the test values:
RBCs: Normal- slight increase
WBCs: Normal
Platelets: Normal- slight decrease
Plasma Glucose: greater than 200 mg/dl
pH: 7
Thyroid Profile: TSH levels slightly increased
Bound T4: Normal
Bound T3: Normal
Urine test:
RBC: None
Pus cells: None
Glucose: Present
Ketone Bodies: Present
Urea: Increase
Which is the most likely diagnosis:
a.
Hypothyroidism
b.
Hyperthyroidism
c.
Hyperinsulinemia
d.
Hypoinsulinemia
e.
Ketoacidosis
f.
Anemia
g.
Glucosuria
Scenario I (Usman)
Scenario II (Aqueel)
Scenario III (Asif)
A 40-year old man came to the hospital
with a case of excessive bleeding and
increased clotting time after an injury.
Lab. Report suggest increased levels of
fasting blood glucose levels.
The patient tells that he was not suffering
from high glucose level earlier in his life.
What is the likely cause of his excessive
bleeding?
a.
Diabetes Type I
b.
Hypoinsulinemia
c.
Carcinoma of Pancreas
d.
Diabetes Type II
e.
Cirrhosis of Liver
A 50-year old obese woman presents
to the hospital complaining of
increased urination, increased thirst
and hunger. The Lab. reports
showed:
•Increase Glucose in blood
•Increased Glucose in Urine
•Low blood pH
•
She is most likely suffering from?
a.Ketoacidosis
b.Diabetes Mellitus
c.Hyperinsulinemia
d.Diabetes Inspidus
Scenario IV (?)
Scenario V (Khizra)
An over-weight patient reported to a
doctor with increased urination, having
vision problems with prolonged period
of wound healing. He is complaining of
weakness and increased thirst
(polydipsia). After clinical examination
increased level of glucose found in
blood and urine.
What do you think that which
hormone deficiency is present in the
patient?
a.Thyroid hormone
b.Insulin
c.ADH
d.Glucagon
A 50-year old patient reported to
the doctor with increased urine
output and increased thirst and
hunger. Lab reports show
increased glucose in blood as well
as presence in urine. What would
be the most likely diagnosis?
a.Diabetes mellitus
b.Hypothyroidism
c.Hyperinsulinism
d. carcinoma of Pancreas
Scenario VI (Hana)
A 50-year old woman comes in complaining that she has
polyphagia, frequent urination and numbness in the
peripheries. The doctor advices her to get a blood and
urine test. The result showed that her fasting glucose
levels were 200 mg/ dl and there was glucose present in
her urine.
Which hormone is the patient deficient in?
a. FSH
b. Glucagon
c. Growth hormone
d. Insulin
Name the hormone (Glucagon/ Insulin)
responsible for the processes listed below:
glucose to
glycogen
amino acids to
glucose
protein to
amino acids
glucose to
fats (triglycerides)
glycogen to
glucose
low blood glucose to
high blood glucose
high blood glucose to
low blood glucose
fats (triglycerides) to
fatty acids
fatty acids
fats (triglycerides)
Question 1
"Three meals a day" is our routine, but how is
periodic eating handling internally? Specifically,
how does the endocrine system maintain
internal homeostatic processes, such as blood
glucose, in the face of our "feast or famine"
pattern of eating? Explain.
Question 2
• What are glucose transporters (GLUT), how
are they important, and where are they
found? How does insulin act on these
transporters to increase glucose uptake by
insulin-sensitive cells? Are all cells insulinsensitive? Defend your answer.
Question 3
Rosemary was asked to drink a solution
containing glucose, and blood samples were
taken periodically over a few hours to measure
her plasma glucose concentration; this is an oral
glucose tolerance test. The results were normal.
• How would drinking a glucose solution affect
then secretion of insulin and glucagon?
• If Rosemary had type 2 diabetes mellitus, how
would that have affected the GTT.
Which of the following are characteristic
of the POSTABSORPTIVE/ FED state?
a.
b.
c.
d.
e.
f.
g.
h.
i.
j.
Glycogenolysis
Gluconeogenesis
Lipolysis
Glycogenesis
protein synthesis
triglyceride synthesis
protein degradation
increased insulin secretion
increased glucagon secretion
glucose sparing